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Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research

Fortifying immunity: PLSCR1 picks battle against SARS-CoV-2
Cell Host Microbe. 2023 Sep 13;31(9):1417-1419. doi: 10.1016/j.chom.2023.08.014.ABSTRACTInterferons (IFNs) and interferon-stimulated genes (ISGs) are the major players in the host innate immunity against viral infection. In a recent Nature paper, Xu et al. identified phospholipid scramblase 1 (PLSCR1) as a novel ISG that restricts severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking virus-cell fusion.PMID:37708846 | DOI:10.1016/j.chom.2023.08.014
Source: Cell Host and Microbe - September 14, 2023 Category: Microbiology Authors: Minghua Li Source Type: research

Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI
Int Immunopharmacol. 2023 Sep 12;124(Pt A):110858. doi: 10.1016/j.intimp.2023.110858. Online ahead of print.ABSTRACTAmong various factors influencing the course of SARS-CoV-2 infection in humans, macrophage overactivation is considered the main cause of the cytokine storm that leads to severe complications of COVID-19. Moreover, the increased expression of angiotensin converting enzyme 2 (ACE2), an obligatory entry receptor of the coronavirus, caused by treatment with ACE inhibitors (ACEI) lowered overall confidence in the safety of these drugs. However, analysis of the course of coronavirus infection in patients treated w...
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Dominik Felkle Katarzyna Zi ęba Konrad Kaleta Julia Czaja Amanda Zyzdorf Wiktoria Soboci ńska Mateusz Jarczy ński Krzysztof Bryniarski Katarzyna Nazimek Source Type: research

Animal efficacy study of a plant extract complex (BEN815) as a potential treatment for COVID-19
by Moon Ho Do, Hua Li, Su Yeon Cho, Subin Oh, Ju Hwan Jeong, Min-Suk Song, Jong-Moon Jeong In a short time, several types of injectable and oral therapeutics have been developed and used to effectively manage patients with coronavirus disease 2019 (COVID-19). BEN815 is an improved mixture of three extracts (Psidium guajava,Camellia sinensis, andRosa hybrida) recognized by the Ministry of Food and Drug Safety of Korea as a health food ingredient that alleviates allergic rhinitis. The current animal efficacy study was performed to assess its probability of improving COVID-19 symptoms. BEN815 treatment significantly increase...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Moon Ho Do Source Type: research

Viruses, Vol. 15, Pages 1921: microRNA-185 Inhibits SARS-CoV-2 Infection through the Modulation of the Host & rsquo;s Lipid Microenvironment
Viruses, Vol. 15, Pages 1921: microRNA-185 Inhibits SARS-CoV-2 Infection through the Modulation of the Host’s Lipid Microenvironment Viruses doi: 10.3390/v15091921 Authors: Nadine Ahmed Magen E. Francis Noreen Ahmed Alyson A. Kelvin John Paul Pezacki With the emergence of the novel betacoronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), there has been an urgent need for the development of fast-acting antivirals, particularly in dealing with different variants of concern (VOC). SARS-CoV-2, like other RNA viruses, depends on host cell machinery to propagate and misregulate meta...
Source: Viruses - September 14, 2023 Category: Virology Authors: Nadine Ahmed Magen E. Francis Noreen Ahmed Alyson A. Kelvin John Paul Pezacki Tags: Article Source Type: research

Association between post-COVID-19 status and perioperative morbidity and mortality: protocol for an ambispective cohort study
This study aims to explore the association between time to surgery after COVID-19 diagnosis and the risk of postoperative morbidity and mortality. Methods and analysis This is a single-centre ambispective cohort study. Patients with preoperative SARS-CoV-2 infection who require inpatient surgical intervention from 1 December 2022 to 28 February 2023 will be included. Baseline assessment will include the time interval between preoperative SARS-CoV-2 infection and surgery, COVID-19 diagnosis and symptoms, vaccination status and routine preoperative evaluations. The primary outcome will be postoperative composite complicatio...
Source: BMJ Open - September 14, 2023 Category: General Medicine Authors: Che, L., Yu, J., Bai, X., Wang, Y., Zhang, Y., Xu, L., Shen, L., Huang, Y. Tags: Open access, Anaesthesia, COVID-19 Source Type: research

Acute motor-sensory axonal polyneuropathy variant of Guillain-Barr é syndrome with a thalamic lesion and COVID-19: a case report and discussion on mechanism
ConclusionThe AMSAN variant of GBS secondary to COVID-19 infection is severe and can cause extensive damage to the peripheral nerves system. The deterioration of symptoms in the patient after early immunotherapy may indicate treatment-related fluctuation (TRF) and could be attributed to immune rebound. Moreover, an excessive immune response post-COVID-19 infection may trigger concurrent damage to the central nervous system, indicating secondary harm to brain small blood vessels and nerve units. For suspected cases of GBS complicated by COVID-19, it is essential to conduct early brain MRI examinations in addition to routine...
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research

Impact of the Covid-19 pandemic on the management of gynecologic cancer: a Spanish survey. Observational, multicenter study
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) pandemic changed the distribution of healthcare resources, leading in many cases to the suspension of all non-essential treatments and procedure...
Source: BMC Women's Health - September 14, 2023 Category: OBGYN Authors: Myriam Gracia, Elena Rodr íguez, María Dolores Diestro, Emanuela Spagnolo, Virginia García, Jaime Siegrist, Yolanda Pérez, Ignacio Zapardiel and Alicia Hernández Tags: Research Source Type: research

Hair disorders associated with post-COVID-19 infection in females: a cross-sectional study
ConclusionIn conclusion, we reported prevalence of post-COVID hair fall that was confirmed by trichoscopy and which affected approximately 61.4% of infected females.
Source: Irish Journal of Medical Science - September 14, 2023 Category: General Medicine Source Type: research

Moderna ' s improved mRNA covid-19 vaccine is effective at lower doses
A streamlined version of Moderna ’s vaccine that targets only key parts of the spike protein of the SARS-CoV-2 coronavirus is being trialled in humans
Source: New Scientist - Health - September 13, 2023 Category: Consumer Health News Source Type: research

The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
Conditions: COVID-19; Hypoxemic Respiratory Failure Intervention: Device: High flow nasal oxygen (HFNO, more than 15 L/min) Sponsor: Amsterdam UMC, location VUmc Active, not recruiting
Source: ClinicalTrials.gov - September 13, 2023 Category: Research Source Type: clinical trials

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