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Antiviral Activity of Cinchona officinalis, a Homeopathic Medicine, against COVID-19
CONCLUSION: Based on this in silico and in vitro evidence, we propose CO-MT as a promising antiviral medicine candidate for treating COVID-19. In vivo investigation is required to clarify the therapeutic potential of CO-MT in COVID-19.PMID:37673083 | DOI:10.1055/s-0043-1770339
Source: Homeopathy - September 6, 2023 Category: Complementary Medicine Authors: Somasundaram Arumugam Kumaravel Vadivel Devendra Kumar Dhaked Vani Sai Prasanna Manoj Limbraj Yellurkar Pamelika Das Raja Manoharan Austin Jose Thomas Lalith Singh Subhas Singh Ravichandiran Velayutham Source Type: research
GSE237092 Impact of Age and Sex on neuroinflammation due to SARS-CoV2 infection in a murine model.
Conclusions: Our findings demonstrate that age, and sex, modify the progression and outcome of SARS-CoV-2 infection. SARS-CoV-2 infection triggers neuroinflammatory responses despite the lack of detectable virus in the brain. Changes in molecular networks of innate immunity and defense response to microorganisms underlie the impact of SARS-CoV-2 infection in the brain. These findings in mice mimic epidemiological and clinical observations in humans with Covid-19.
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Study of efficacy and antibody duration to fourth-dose booster of Ad5-nCoV or inactivated SARS-CoV-2 vaccine in Chinese adults: a prospective cohort study
DiscussionCompared with a homologous fourth dose, a heterologous fourth dose of Ad5-nCoV elicited a higher immunogenic response in healthy adults who had been immunized with three doses of inactivated vaccine. Nevertheless, the efficacy of the two vaccine types was equivalent after the pandemic.
Source: Frontiers in Immunology - September 6, 2023 Category: Allergy & Immunology Source Type: research
Investigation of the individual genetic evolution of SARS-CoV-2 in a small cluster during the rapid spread of the BF.5 lineage in Tokyo, Japan
There has been a decreasing trend in new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases and fatalities worldwide. The virus has been evolving, indicating the potential emergence of new variants and uncertainties. These challenges necessitate continued efforts in disease control and mitigation strategies. We investigated a small cluster of SARS-CoV-2 Omicron variant infections containing a common set of genomic mutations, which provided a valuable model for investigating the transmission mechanism of genetic alterations. We conducted a study at a medical center in Japan during the Omicron surge (sub-line...
Source: Frontiers in Microbiology - September 6, 2023 Category: Microbiology Source Type: research
Spike Protein is a key target for stronger and more persistent T-Cell Responses – A study of mild and asymptomatic SARS-CoV-2 Infection.
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus led to devastating consequences, with over 768,983,095 confirmed cases and 6,953,743 million deaths reported as of 26th July 2023 (WHO, 2023 https://covid19.who.int/). Highlighting the critical importance of both T-cell and antibody responses is imperative for effectively addressing the complexities posed by COVID-19. Amidst the significant antibody research, there's a growing realisation that understanding and leveraging T-cell responses is pivotal for designing efficacious SARS-CoV-2 vaccines ...
Source: International Journal of Infectious Diseases - September 6, 2023 Category: Infectious Diseases Authors: Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, The COVID-19 Immunoprofiling Team, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christophe Source Type: research
Telogen effluvium and COVID-19: a cross-sectional study
CONCLUSIONS: In our study, the incidence of TE was highly related to COVID-19 infections among both sexes. However, the incidence was greater among the female population. The awareness level toward post-COVID-19 TE was poor among most of the participants in our study.PMID:37667959 | DOI:10.26355/eurrev_202308_33437
Source: European Review for Medical and Pharmacological Sciences - September 5, 2023 Category: Drugs & Pharmacology Authors: A Aldahish R Vasudevan H Salem A Alqahtani S AlQasim A Alqhatani M Al Shahrani L Al Mohsen M Hajla D Calina J Sharifi-Rad Source Type: research
Olfactory System: Basic Anatomy and Physiology for General Otorhinolaryngologists
Clin Exp Otorhinolaryngol. 2023 Sep 4. doi: 10.21053/ceo.2023.00185. Online ahead of print.ABSTRACTOlfaction is one of the five basic human senses, and it is known to be one of the most primitive senses. The sense of olfaction may have been critical for human survival in prehistoric society, and although many believe its importance has diminished over time, its impact on human interaction, bonding, and propagation of the species remains. Even if we are unaware of it, the sense of smell greatly affects our lives. Sense of smell is closely related to overall quality of life and health. However, olfaction has been neglected f...
Source: Clinical and Experimental Otorhinolaryngology - September 5, 2023 Category: ENT & OMF Authors: Sun A Han Jin Kook Kim Do-Yeon Cho Zara M Patel Chae-Seo Rhee Source Type: research
Coronavirus disease 2019 is associated with long-term depressive symptoms in Spanish older adults with overweight/obesity and metabolic syndrome
CONCLUSIONS: COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.PMID:37667630 | DOI:10.1017/S0033291723002313
Source: Psychological Medicine - September 5, 2023 Category: Psychiatry Authors: Sangeetha Shyam Carlos G ómez-Martínez Indira Paz-Graniel Jos é J Gaforio Miguel Ángel Martínez-González Dolores Corella Montserrat Fit ó J Alfredo Mart ínez Ángel M Alonso-Gómez Julia W ärnberg Jes ús Vioque Dora Romaguera Jos é López-Miran Source Type: research
Impact of the new coronavirus (SARS-CoV-2) pandemic on climacteric women's health: Websurvey
CONCLUSION: We observed an important reduction in the health care of climacteric women during the pandemic period, such as a decrease in medical consultations and preventive examinations, worsening of life habits and deterioration in mental health.PMID:37669691 | DOI:10.1080/13697137.2023.2246877
Source: Climacteric - September 5, 2023 Category: Geriatrics Authors: L G Pezzali F V Ferreira F V Ferreira M C O Wender Source Type: research
