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Total 19258 results found since Jan 2013.
LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data
ConclusionsThis study showed that not all LABA/LAMA FDCs were superior to LABA/ICS FDCs in safety and in preventing moderate or severe exacerbations in patients with stable COPD, providing important quantitative information for COPD-related guidelines.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
The role of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis and monitoring of large vessel vasculitides - a review article
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):127-135. eCollection 2023.ABSTRACTIn the last two decades, advancements in positron emission tomography (PET) technology have increased the diagnostic accuracy of patients with large-vessel vasculitis (LVV). Numerous systematic reviews and meta-analyses have been conducted, and patients suspected of having LVV can be diagnosed earlier with 18F-FDG PET. Two subtypes, giant cell arteritis (GCA) and Takayasu arteritis (TA), will progress when their response to corticosteroids and enhanced immunosuppression is inadequate. In the majority of patients, disease activity cannot be monit...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Mahshid Bahrami Hossein Mohammadi Hannaneh Mirgaloyebayat Zahra Mohajeri Pooya Fazeli Azad Mojahedi Ali Afsharirad Reza Tavakoli Amirhossein Sadeghian Sayed Mohammad Amin Nourian Source Type: research
Antenatal corticosteroids in specific groups at risk of preterm birth: a systematic review
Conclusions
There is a paucity of evidence on ACS for women who have diabetes. ACS therapy may have benefits in women with chorioamnionitis and is probably beneficial in FGR. There is limited direct trial evidence on ACS efficacy in women undergoing planned CS in the late preterm period, though the totality of evidence suggests it is probably beneficial.
PROSPERO registration number
CRD42021267816.
Source: BMJ Open - September 22, 2023 Category: General Medicine Authors: Saito, K., Nishimura, E., Ota, E., Namba, F., Swa, T., Ramson, J., Lavin, T., Cao, J., Vogel, J. P. Tags: Open access, Paediatrics Source Type: research
Mucormycosis: update on clinical presentation, diagnosis, and treatment
Curr Opin Infect Dis. 2023 Sep 22. doi: 10.1097/QCO.0000000000000976. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Mucormycosis (MCR) is a common opportunistic mold infection, and Mucorales were recently designated by WHO as priority pathogens. The interest in this infection has risen significantly since the major outbreak of MCR in the context of the COVID-19 pandemic, particularly in India. Herein, we summarize recently (last 24 months) published information regarding clinical aspects of MCR.RECENT FINDINGS: The disease remains protean in its clinical presentation, difficult to diagnose, and challenging to treat. In ...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Natalie J M Dailey Garnes Dimitrios P Kontoyiannis Source Type: research
Omalizumab for Chinese patients with moderate-to-severe allergic asthma in real-world clinical setting: a prospective, observational study
CONCLUSIONS: In real-world clinical practice, omalizumab treatment remarkably reduced exacerbations in Chinese patients with moderate-to-severe asthma. Omalizumab reduced the use of oral corticosteroids and improved asthma control and pulmonary function.PMID:37734750 | DOI:10.1136/bmjresp-2022-001549
Source: Respiratory Care - September 21, 2023 Category: Respiratory Medicine Authors: Wen Wang Jieying Li Congying Zou Lifang Zhao Ya Zhu Yue Guo Feiran Wang Source Type: research
Factors associated with sarcopenia in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study
Clin Rheumatol. 2023 Sep 21. doi: 10.1007/s10067-023-06779-2. Online ahead of print.ABSTRACTTo investigate the prevalence of and factors associated with sarcopenia in Japanese patients with rheumatoid arthritis (RA). We analyzed a cross-section of patients with RA participating in the Institute of Rheumatology Rheumatoid Arthritis cohort survey in 2021. Participants completed self-administered questionnaires, including a 5-item sarcopenia screening index (SARC-F). Patients with a SARC-F score of 4 or higher were categorized as having sarcopenia. Among 2416 Japanese patients with RA (2113 women and 303 men; mean age 63.9 ye...
Source: Pain Physician - September 21, 2023 Category: Anesthesiology Authors: Masanori Nakayama Takefumi Furuya Eisuke Inoue Eiichi Tanaka Katsunori Ikari Hisashi Yamanaka Masayoshi Harigai Source Type: research
A Case of Pyoderma Gangrenosum after Partial Small Bowel Resection
This report presents the case of a 55-year-old man who underwent partial small bowel resection for incomplete intestinal obstruction and developed postoperative infection-like manifestations, including redness and swelling of the incision, severe pain, and yellow-green turbid fluid from the drainage tube. After completing a skin biopsy that suggested massive neutrophil infiltration, multiple secretion cultures for Pseudomonas aeruginosa (+), and systemic screening without other comorbidities, a diagnosis of postoperative PG and P aeruginosa infection was determined.Early detection of this complication is essential for pati...
Source: Pain Physician - September 20, 2023 Category: Anesthesiology Authors: Jianing Wang Shiyao Jiang Xin Shi Wenlin Li Qianchun Yu Ting Pan Yuzhu Mu Lingling Chen Source Type: research
Diagnosis and Treatment of IgA Nephropathy-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):621-627. doi: 10.1007/s00508-023-02257-6. Epub 2023 Sep 20.ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis. It leads to end-stage kidney disease in about a third of the patients within 10 to 20 years. The pathogenesis of IgAN is incompletely understood. It is believed that a dysregulation of the mucosal immune system leads to undergalactosylation of IgA, followed by formation of IgG autoantibodies against undergalactosylated IgA, circulation of these IgG-IgA immune complexes, deposition of the immune complexes in the mesangium, ultimately resulti...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Judith Schimpf Andreas Kronbichler Martin Windpessl Emanuel Zitt Kathrin Eller Marcus D S äemann Karl Lhotta Michael Rudnicki Source Type: research
Corticosteroid Use and Adherence in Patients Treated with Acthar Gel for Advanced Sarcoidosis
CONCLUSION: Acthar Gel is associated with reductions in corticosteroid use compared to alternatives. Better adherence is associated with greater reduction in corticosteroid exposure. Key Summary Points.PMID:37728695 | DOI:10.1007/s12325-023-02630-x
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Kyle Hayes John Niewoehner J Bradford Rice Nathaniel Downes Ella Hagopian Izzy Ma George J Wan Source Type: research
Clinical characteristics and treatment efficacy of immune checkpoint inhibitors (ICIs) in patients with ICIs-induced Adrenal insufficiency
CONCLUSIONS: ICI-induced AI is a rare irAE, and close monitoring of cortisol levels is important. Patients diagnosed with AI after receiving immunotherapy seem to have a favorable outcome.PMID:37729740 | DOI:10.1016/j.tranon.2023.101787
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jing Xiang Xueni Liu Yue Hao Yanyan Zhu Minhua Wu Jian Lou Yonghui Wang Chunwei Xu Yanru Xie Jianhui Huang Source Type: research
Corticosteroid Use and Adherence in Patients Treated with Acthar Gel for Advanced Sarcoidosis
CONCLUSION: Acthar Gel is associated with reductions in corticosteroid use compared to alternatives. Better adherence is associated with greater reduction in corticosteroid exposure. Key Summary Points.PMID:37728695 | DOI:10.1007/s12325-023-02630-x
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Kyle Hayes John Niewoehner J Bradford Rice Nathaniel Downes Ella Hagopian Izzy Ma George J Wan Source Type: research
Clinical characteristics and treatment efficacy of immune checkpoint inhibitors (ICIs) in patients with ICIs-induced Adrenal insufficiency
CONCLUSIONS: ICI-induced AI is a rare irAE, and close monitoring of cortisol levels is important. Patients diagnosed with AI after receiving immunotherapy seem to have a favorable outcome.PMID:37729740 | DOI:10.1016/j.tranon.2023.101787
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jing Xiang Xueni Liu Yue Hao Yanyan Zhu Minhua Wu Jian Lou Yonghui Wang Chunwei Xu Yanru Xie Jianhui Huang Source Type: research
Adrenal hemorrhage and non-ST elevation myocardial infarction: an antiphospholipid syndrome dilemma
Reumatismo. 2023 Sep 18;75(3). doi: 10.4081/reumatismo.2023.1584.ABSTRACTAntiphospholipid syndrome (APS) can affect different organ systems, including the heart and adrenal glands. Despite being known for its prothrombotic characteristics, APS can have serious bleeding complications. Occasionally, thrombotic and bleeding episodes can present simultaneously in an APS patient. Whenever these events co-occur, resuming anticoagulation becomes a topic of debate. As such, we present the case of a 43-year-old male with triple positive antiphospholipid antibodies, indicating APS, who presented with chest pain. Anticoagulants were ...
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: G El Hasbani M Del Pilar Morel B Tandoh J F Vargas R Crusio Source Type: research
