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Therapy: Radiation Therapy
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Total 11587 results found since Jan 2013.
LDR-Brachytherapy monotherapy appears unsuited for NCCN unfavorable intermediate-risk prostate cancer patients
CONCLUSIONS: Subclassification of IR prostate cancer into FIR and UIR subcategories appears mandatory. For FIR patients, outcomes after BT monotherapy were acceptable. However, clinical failure after 125J-LDR-BT in UIR patients was notably increased, suggesting that BT monotherapy was less successful in this risk group. In contrast, the outcome in UIR patients after CRT was excellent.PMID:37714724 | DOI:10.1016/j.urolonc.2023.08.007
Source: Urologic Oncology - September 15, 2023 Category: Urology & Nephrology Authors: Andreas Boehle Dorothea Zywietz Irina Robrahn-Nitschke Achim Lusch Inke R K önig Source Type: research
Incorporating Tumor Biology to Select Patients for the Omission of Radiation Therapy
Surg Oncol Clin N Am. 2023 Oct;32(4):725-732. doi: 10.1016/j.soc.2023.05.006. Epub 2023 Jun 9.ABSTRACTAlthough adjuvant breast radiotherapy has long been a universal component of breast conservation therapy (BCT), it is now clear that "breast cancer" is a broad class of many disparate diseases with varying natural histories and risk profiles. In turn, some breast conservation patients enjoy exceedingly favorable outcomes following surgery alone. Ongoing trials seek to identify such low-risk patient populations, hypothesizing that some may safely forego radiotherapy. Whereas prior-generation trials focused on clinicopatholo...
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lior Z Braunstein Source Type: research
LDR-Brachytherapy monotherapy appears unsuited for NCCN unfavorable intermediate-risk prostate cancer patients
CONCLUSIONS: Subclassification of IR prostate cancer into FIR and UIR subcategories appears mandatory. For FIR patients, outcomes after BT monotherapy were acceptable. However, clinical failure after 125J-LDR-BT in UIR patients was notably increased, suggesting that BT monotherapy was less successful in this risk group. In contrast, the outcome in UIR patients after CRT was excellent.PMID:37714724 | DOI:10.1016/j.urolonc.2023.08.007
Source: Urologic Oncology - September 15, 2023 Category: Urology & Nephrology Authors: Andreas Boehle Dorothea Zywietz Irina Robrahn-Nitschke Achim Lusch Inke R K önig Source Type: research
Analysis and prediction of liver volume change maps derived from computational tomography scans acquired pre- and post-radiation therapy
This study leverages the use of deep learning-based segmentation and biomechanical deformable image registration (DIR) to analyze and predict this relationship. Pre- and Post-EBRT imaging data were collected for 100 patients treated for HCC, CC or CRC with IMRT with prescription doses ranging from 50 to 100 Gy delivered in 10 to 28 fractions. For each patient, DIR between the portal and venous (PV) phase of a diagnostic CT scan acquired before RT planning, and a PV phase of a diagnostic CT scan acquired after the end of RT (on average 147±36 days) was performed to calculate Jacobian maps representing volume changes in the...
Source: Physics in Medicine and Biology - September 15, 2023 Category: Physics Authors: Guillaume Cazoulat Aashish C Gupta Mais M Al Taie Eugene J Koay Kristy K Brock Source Type: research
Deep learning in MRI-guided radiation therapy: A systematic review
J Appl Clin Med Phys. 2023 Sep 15:e14155. doi: 10.1002/acm2.14155. Online ahead of print.ABSTRACTRecent advances in MRI-guided radiation therapy (MRgRT) and deep learning techniques encourage fully adaptive radiation therapy (ART), real-time MRI monitoring, and the MRI-only treatment planning workflow. Given the rapid growth and emergence of new state-of-the-art methods in these fields, we systematically review 197 studies written on or before December 31, 2022, and categorize the studies into the areas of image segmentation, image synthesis, radiomics, and real time MRI. Building from the underlying deep learning methods,...
Source: Journal of Applied Clinical Medical Physics - September 15, 2023 Category: Physics Authors: Zach Eidex Yifu Ding Jing Wang Elham Abouei Richard L J Qiu Tian Liu Tonghe Wang Xiaofeng Yang Source Type: research
Incorporating Tumor Biology to Select Patients for the Omission of Radiation Therapy
Surg Oncol Clin N Am. 2023 Oct;32(4):725-732. doi: 10.1016/j.soc.2023.05.006. Epub 2023 Jun 9.ABSTRACTAlthough adjuvant breast radiotherapy has long been a universal component of breast conservation therapy (BCT), it is now clear that "breast cancer" is a broad class of many disparate diseases with varying natural histories and risk profiles. In turn, some breast conservation patients enjoy exceedingly favorable outcomes following surgery alone. Ongoing trials seek to identify such low-risk patient populations, hypothesizing that some may safely forego radiotherapy. Whereas prior-generation trials focused on clinicopatholo...
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lior Z Braunstein Source Type: research
Trauma-Informed Care in Medical Imaging and Radiation Therapy to Reduce Retraumatization
CONCLUSION: Because many aspects of care, including routine care in medical imaging and radiation therapy, can be an unintentional reminder of a traumatic experience, health care professionals should be trauma-informed when they are interacting with and caring for patients.PMID:37709517
Source: Radiologic Technology - September 14, 2023 Category: Radiology Authors: Kevin R Clark Jennifer S Sonsiadek Source Type: research
Applications of tissue-specific and cancer-selective gene promoters for cancer diagnosis and therapy
Adv Cancer Res. 2023;160:253-315. doi: 10.1016/bs.acr.2023.03.005. Epub 2023 Apr 20.ABSTRACTCurrent treatment of solid tumors with standard of care chemotherapies, radiation therapy and/or immunotherapies are often limited by severe adverse toxic effects, resulting in a narrow therapeutic index. Cancer gene therapy represents a targeted approach that in principle could significantly reduce undesirable side effects in normal tissues while significantly inhibiting tumor growth and progression. To be effective, this strategy requires a clear understanding of the molecular biology of cancer development and evolution and develo...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Amit Kumar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research
Systemic therapy escalation after stereotactic body radiation therapy for oligometastatic hormone-sensitive prostate cancer
CONCLUSION: With excellent local control and tolerance, SBRT for omHSPC patients represents an attractive approach to defer systemic therapeutic escalation and prevent its side effects. Accurate patient selection for SBRT requires more data with longer follow-up and higher numbers of patients pending the results of upcoming randomized trials.PMID:37701481 | PMC:PMC10493250 | DOI:10.1016/j.ctro.2023.100673
Source: Clinical Prostate Cancer - September 13, 2023 Category: Cancer & Oncology Authors: D Baron D Pasquier T Pace-Loscos B Vandendorpe R Schiappa C Ortholan J M Hannoun-Levi Source Type: research
Applications of tissue-specific and cancer-selective gene promoters for cancer diagnosis and therapy
Adv Cancer Res. 2023;160:253-315. doi: 10.1016/bs.acr.2023.03.005. Epub 2023 Apr 20.ABSTRACTCurrent treatment of solid tumors with standard of care chemotherapies, radiation therapy and/or immunotherapies are often limited by severe adverse toxic effects, resulting in a narrow therapeutic index. Cancer gene therapy represents a targeted approach that in principle could significantly reduce undesirable side effects in normal tissues while significantly inhibiting tumor growth and progression. To be effective, this strategy requires a clear understanding of the molecular biology of cancer development and evolution and develo...
Source: Advances in Cancer Research - September 13, 2023 Category: Cancer & Oncology Authors: Amit Kumar Swadesh K Das Luni Emdad Paul B Fisher Source Type: research
