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Total 11587 results found since Jan 2013.
Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization
CONCLUSION: The INSIGhT design enabled efficient simultaneous testing of three experimental agents using a shared control arm and adaptive randomization. Two investigational arms had superior PFS compared with the control arm, but none demonstrated an OS benefit. The INSIGhT design may promote improved and more efficient therapeutic discovery in glioblastoma. New arms have been added to the trial.PMID:37722087 | DOI:10.1200/JCO.23.00493
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Rifaquat Rahman Lorenzo Trippa Eudocia Q Lee Isabel Arrillaga-Romany Geoffrey Fell Mehdi Touat Christine McCluskey Jennifer Wiley Sarah Gaffey Jan Drappatz Mary R Welch Evanthia Galanis Manmeet S Ahluwalia Howard Colman L Burt Nabors Jaroslaw Hepel Heinri Source Type: research
Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy
In conclusion, SV cranial displacement was influenced by HS lateral distribution of ≥1.00 cm in the upper two slices. Therefore, when the sigmoid colon or small bowel is depressed in rectovesical excavation and SV needs to be included in the target volume, HS insertion should be performed carefully.PMID:37719041 | PMC:PMC10502802 | DOI:10.3892/mco.2023.2674
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kenji Makita Yasushi Hamamoto Hiromitsu Kanzaki Kei Nagasaki Katsuyoshi Hashine Source Type: research
The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy
CONCLUSION: The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.PMID:37716368 | DOI:10.1002/acm2.14162
Source: Journal of Applied Clinical Medical Physics - September 16, 2023 Category: Physics Authors: Atefeh Rostami Mostafa Robatjazi Seyed Alireza Javadinia Nematullah Shomoossi Ramin Shahraini Source Type: research
Adult Laryngeal Pleomorphic Rhabdomyosarcoma: A Rare Entity
Ear Nose Throat J. 2023 Sep 16:1455613231198986. doi: 10.1177/01455613231198986. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is a rare and aggressive cancerous tumor that arises from embryonal mesenchymal cells with skeletal muscle differentiation, and it is exceedingly rare that occurs specifically in the larynx. To date, only 22 instances of laryngeal pleomorphic RMSs have been documented in adults. Consequently, there is limited information available to assist healthcare professionals in effectively handling RMS in the larynx of adult patients. Here, we present an uncommon occurrence involving a 45-year-old man...
Source: Ear, Nose and Throat Journal - September 16, 2023 Category: ENT & OMF Authors: Hua Cai Shan Chen Zhuo-Ya Zhang Bei-Bei Gao Yan-Yan Ding Bang-Hua Liu Wen-Wen Wang Source Type: research
The influence of patient positioning and immobilization equipment on MR image quality and image registration in radiation therapy
CONCLUSION: The image quality reduction in the RT setup was due to the imaged region's anatomy and its position relative to the applied coil. Furthermore, optimizing the pulse sequence is crucial for MR imaging in RT applications. Although the use of immobilization equipment may decrease the image quality in the RT setup, it does not affect organ delineation, and the image quality is still satisfactory for this purpose. Also, the use of immobilization equipment in the RT setup has increased registration accuracy.PMID:37716368 | DOI:10.1002/acm2.14162
Source: Journal of Applied Clinical Medical Physics - September 16, 2023 Category: Physics Authors: Atefeh Rostami Mostafa Robatjazi Seyed Alireza Javadinia Nematullah Shomoossi Ramin Shahraini Source Type: research
Incorporating Tumor Biology to Select Patients for the Omission of Radiation Therapy
Surg Oncol Clin N Am. 2023 Oct;32(4):725-732. doi: 10.1016/j.soc.2023.05.006. Epub 2023 Jun 9.ABSTRACTAlthough adjuvant breast radiotherapy has long been a universal component of breast conservation therapy (BCT), it is now clear that "breast cancer" is a broad class of many disparate diseases with varying natural histories and risk profiles. In turn, some breast conservation patients enjoy exceedingly favorable outcomes following surgery alone. Ongoing trials seek to identify such low-risk patient populations, hypothesizing that some may safely forego radiotherapy. Whereas prior-generation trials focused on clinicopatholo...
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lior Z Braunstein Source Type: research
Analysis and prediction of liver volume change maps derived from computational tomography scans acquired pre- and post-radiation therapy
This study leverages the use of deep learning-based segmentation and biomechanical deformable image registration (DIR) to analyze and predict this relationship. Pre- and Post-EBRT imaging data were collected for 100 patients treated for HCC, CC or CRC with IMRT with prescription doses ranging from 50 to 100 Gy delivered in 10 to 28 fractions. For each patient, DIR between the portal and venous (PV) phase of a diagnostic CT scan acquired before RT planning, and a PV phase of a diagnostic CT scan acquired after the end of RT (on average 147±36 days) was performed to calculate Jacobian maps representing volume changes in the...
Source: Physics in Medicine and Biology - September 15, 2023 Category: Physics Authors: Guillaume Cazoulat Aashish C Gupta Mais M Al Taie Eugene J Koay Kristy K Brock Source Type: research
Deep learning in MRI-guided radiation therapy: A systematic review
J Appl Clin Med Phys. 2023 Sep 15:e14155. doi: 10.1002/acm2.14155. Online ahead of print.ABSTRACTRecent advances in MRI-guided radiation therapy (MRgRT) and deep learning techniques encourage fully adaptive radiation therapy (ART), real-time MRI monitoring, and the MRI-only treatment planning workflow. Given the rapid growth and emergence of new state-of-the-art methods in these fields, we systematically review 197 studies written on or before December 31, 2022, and categorize the studies into the areas of image segmentation, image synthesis, radiomics, and real time MRI. Building from the underlying deep learning methods,...
Source: Journal of Applied Clinical Medical Physics - September 15, 2023 Category: Physics Authors: Zach Eidex Yifu Ding Jing Wang Elham Abouei Richard L J Qiu Tian Liu Tonghe Wang Xiaofeng Yang Source Type: research
Clinical application of magnetic resonance lymphangiography in the vascularized omental lymph nodes transfer with or without lymphaticovenous anastomosis for cancer-related lower extremity lymphedema
CONCLUSIONS: The precision evaluation of inguinal lymph nodes and lower extremities lymphatic system through MRL using VOLT can provide surgeons with a comprehensive understanding and reliable evidence for the treatment of cancer-related lower extremity lymphedema.PMID:37711785 | PMC:PMC10498210 | DOI:10.21037/qims-22-1443
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Gechang Cheng Yingxing Duan Qin Xiong Wenguang Liu Fang Yu Liming Qing Panfeng Wu Liansheng Gong Xiaoli Li Juyu Tang Source Type: research
LDR-Brachytherapy monotherapy appears unsuited for NCCN unfavorable intermediate-risk prostate cancer patients
CONCLUSIONS: Subclassification of IR prostate cancer into FIR and UIR subcategories appears mandatory. For FIR patients, outcomes after BT monotherapy were acceptable. However, clinical failure after 125J-LDR-BT in UIR patients was notably increased, suggesting that BT monotherapy was less successful in this risk group. In contrast, the outcome in UIR patients after CRT was excellent.PMID:37714724 | DOI:10.1016/j.urolonc.2023.08.007
Source: Urologic Oncology - September 15, 2023 Category: Urology & Nephrology Authors: Andreas Boehle Dorothea Zywietz Irina Robrahn-Nitschke Achim Lusch Inke R K önig Source Type: research
Stereotactic Body Radiation Therapy for Oligoprogressive and Oligorecurrent Non-Small-Cell Lung Cancer
CONCLUSION: SBRT is a safe and viable treatment option for oligoprogressive and oligorecurrent NSCLC. Patients with 0 to 2 sites had better OS and longer TNT-D compared to those with 3 to 5 lesions.PMID:37714807 | DOI:10.1016/j.cllc.2023.08.015
Source: Clinical Lung Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Maryam Ebadi Colton Ladbury Jason Liu Adam Rock Mykola Onyshchenko Victoria Villaflor Miguel Villalona-Calero Ravi Salgia Erminia Massarelli Percy Lee Terence Williams Arya Amini Source Type: research
Clinical application of magnetic resonance lymphangiography in the vascularized omental lymph nodes transfer with or without lymphaticovenous anastomosis for cancer-related lower extremity lymphedema
CONCLUSIONS: The precision evaluation of inguinal lymph nodes and lower extremities lymphatic system through MRL using VOLT can provide surgeons with a comprehensive understanding and reliable evidence for the treatment of cancer-related lower extremity lymphedema.PMID:37711785 | PMC:PMC10498210 | DOI:10.21037/qims-22-1443
Source: Hand Surgery - September 15, 2023 Category: Surgery Authors: Gechang Cheng Yingxing Duan Qin Xiong Wenguang Liu Fang Yu Liming Qing Panfeng Wu Liansheng Gong Xiaoli Li Juyu Tang Source Type: research
