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Arbovirology and Cold War Collaborations: A Transnational History of the Tick-borne Encephalitis Vaccine, 1930-1980
This article analyzes the history of immunization against tick-borne encephalitis (TBE) and specifically the processes that led to the creation and application of TBE vaccines in the Soviet Union and Austria. Rather than presenting the development of TBE vaccines from the perspective of national scientific schools, the article investigates their history as a transnational project, focusing on the connections among the Soviet Union, Czechoslovakia, Austria, the United States, and the United Kingdom. It argues that biomedical research on TBE was profoundly intertwined with political and military agendas and depended on civil...
Source: Medical History - September 8, 2023 Category: History of Medicine Authors: Anna Mazanik Source Type: research

Increased risk of colon cancer after acute appendicitis: a nationwide, population-based study
EClinicalMedicine. 2023 Aug 30;63:102196. doi: 10.1016/j.eclinm.2023.102196. eCollection 2023 Sep.ABSTRACTBACKGROUND: Acute appendicitis is the most common digestive disease requiring emergency surgery. Colorectal cancer is the third most common cancer in France. An increased risk of colorectal cancer after acute appendicitis has been suggested. We aimed to assess the frequency of hospitalization for colon cancer after appendicitis in a nationwide analysis.METHODS: Using the French Hospital Discharge Database (PMSI), we included all patients aged 18-59 years presenting with acute appendicitis between 2010 and 2015. Univari...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Manon Viennet Sol ène Tapia Jonathan Cottenet Alain Bernard Pablo Ortega-Deballon Catherine Quantin Source Type: research

Arbovirology and Cold War Collaborations: A Transnational History of the Tick-borne Encephalitis Vaccine, 1930-1980
This article analyzes the history of immunization against tick-borne encephalitis (TBE) and specifically the processes that led to the creation and application of TBE vaccines in the Soviet Union and Austria. Rather than presenting the development of TBE vaccines from the perspective of national scientific schools, the article investigates their history as a transnational project, focusing on the connections among the Soviet Union, Czechoslovakia, Austria, the United States, and the United Kingdom. It argues that biomedical research on TBE was profoundly intertwined with political and military agendas and depended on civil...
Source: Medical History - September 8, 2023 Category: History of Medicine Authors: Anna Mazanik Source Type: research

Efficacy and safety of upadacitinib maintenance therapy for moderately to severely active ulcerative colitis in patients responding to 8 week induction therapy (U-ACHIEVE Maintenance): overall results from the randomised, placebo-controlled, double-blind, phase 3 maintenance study
Lancet Gastroenterol Hepatol. 2023 Sep 5:S2468-1253(23)00208-X. doi: 10.1016/S2468-1253(23)00208-X. Online ahead of print.ABSTRACTBACKGROUND: Upadacitinib is an oral, selective, and reversible JAK inhibitor with demonstrated efficacy in patients with moderately to severely active ulcerative colitis in a phase 2b induction trial, two phase 3 induction trials (U-ACHIEVE Induction and U-ACCOMPLISH), and a primary analysis of the first 451 patients entering a subsequent maintenance trial (U-ACHIEVE Maintenance). Here, we present overall results from the entire U-ACHIEVE Maintenance population.METHODS: In this randomised, place...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: S éverine Vermeire Silvio Danese Wen Zhou Dapo Ilo Justin Klaff Gweneth Levy Xuan Yao Su Chen Yuri Sanchez Gonzalez Xavier H ébuterne James O Lindsay Peter D R Higgins Qian Cao Hiroshi Nakase Jean-Fr édéric Colombel Edward V Loftus Remo Panaccione Source Type: research

Arbovirology and Cold War Collaborations: A Transnational History of the Tick-borne Encephalitis Vaccine, 1930-1980
This article analyzes the history of immunization against tick-borne encephalitis (TBE) and specifically the processes that led to the creation and application of TBE vaccines in the Soviet Union and Austria. Rather than presenting the development of TBE vaccines from the perspective of national scientific schools, the article investigates their history as a transnational project, focusing on the connections among the Soviet Union, Czechoslovakia, Austria, the United States, and the United Kingdom. It argues that biomedical research on TBE was profoundly intertwined with political and military agendas and depended on civil...
Source: Medical History - September 8, 2023 Category: History of Medicine Authors: Anna Mazanik Source Type: research

Data Equity for Asian American and Native Hawaiian and Other Pacific Islander People in Reproductive Health Research
Obstet Gynecol. 2023 Sep 7. doi: 10.1097/AOG.0000000000005340. Online ahead of print.ABSTRACTThough racial and ethnic disparities in sexual and reproductive health outcomes are receiving greater interest and research funding, the experiences of Asian American and Native Hawaiian and Other Pacific Islander (NHPI) people are often combined with those of other racial and ethnic minority groups or excluded from data collection altogether. Such treatment is often rationalized because Asian American and NHPI groups comprise a smaller demographic proportion than other racial or ethnic groups, and the model minority stereotype ass...
Source: Obstetrics and Gynecology - September 7, 2023 Category: OBGYN Authors: Katrina J Heyrana Bliss Kaneshiro Reni Soon Brian T Nguyen Melissa F Natavio Source Type: research

Organizational and budgetary impacts of the implementation of CAR-T cell therapies in a French academic hospital
This study highlighted the workload generated by the management of these new therapies, as well as the fragile balance of financing hospital stays. To date, it seems necessary and even essential to adapt the quotations of the acts dedicated to CAR-T cells activity and to provide adequate funding through an adapted pricing system.PMID:37679208 | DOI:10.1016/j.bulcan.2023.06.011
Source: Bulletin du Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Lucas Fleta M élanie Gauthier Pauline Lider Arnaud Campidelli B éatrice Demoré Dani èle Bensoussan Lo ïc Reppel Source Type: research

Global mental health and its social determinants: How should we intervene?
Behav Res Ther. 2023 Sep 4;169:104402. doi: 10.1016/j.brat.2023.104402. Online ahead of print.ABSTRACTThis paper makes the case for expanding the field of global mental health to give more attention to the social determinants of mental health. It does so by describing challenges and opportunities for intervening to address these social determinants, and by presenting some potential approaches to the choice, design and evaluation of such interventions, especially in low and middle-income countries. Challenges include distal interventions, limits to the modifiability of some social and economic determinants, poorly understoo...
Source: Behaviour Research and Therapy - September 7, 2023 Category: Psychiatry & Psychology Authors: Crick Lund Source Type: research

Data Equity for Asian American and Native Hawaiian and Other Pacific Islander People in Reproductive Health Research
Obstet Gynecol. 2023 Sep 7. doi: 10.1097/AOG.0000000000005340. Online ahead of print.ABSTRACTThough racial and ethnic disparities in sexual and reproductive health outcomes are receiving greater interest and research funding, the experiences of Asian American and Native Hawaiian and Other Pacific Islander (NHPI) people are often combined with those of other racial and ethnic minority groups or excluded from data collection altogether. Such treatment is often rationalized because Asian American and NHPI groups comprise a smaller demographic proportion than other racial or ethnic groups, and the model minority stereotype ass...
Source: Obstetrics and Gynecology - September 7, 2023 Category: OBGYN Authors: Katrina J Heyrana Bliss Kaneshiro Reni Soon Brian T Nguyen Melissa F Natavio Source Type: research

Global mental health and its social determinants: How should we intervene?
Behav Res Ther. 2023 Sep 4;169:104402. doi: 10.1016/j.brat.2023.104402. Online ahead of print.ABSTRACTThis paper makes the case for expanding the field of global mental health to give more attention to the social determinants of mental health. It does so by describing challenges and opportunities for intervening to address these social determinants, and by presenting some potential approaches to the choice, design and evaluation of such interventions, especially in low and middle-income countries. Challenges include distal interventions, limits to the modifiability of some social and economic determinants, poorly understoo...
Source: Behaviour Research and Therapy - September 7, 2023 Category: Psychiatry & Psychology Authors: Crick Lund Source Type: research