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Total 8950 results found since Jan 2013.
Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis
Lancet Glob Health. 2023 Sep;11(9):e1345-e1362. doi: 10.1016/S2214-109X(23)00305-4.ABSTRACTBACKGROUND: The epidemiology of human papillomavirus (HPV) in women has been well documented. Less is known about the epidemiology of HPV in men. We aim to provide updated global and regional pooled overall, type-specific, and age-specific prevalence estimates of genital HPV infection in men.METHODS: We conducted a systematic review and meta-analysis to assess the prevalence of genital HPV infection in the general male population. We searched Embase, Ovid MEDLINE, and the Global Index Medicus for studies published between Jan 1, 1995...
Source: Cancer Control - August 17, 2023 Category: Cancer & Oncology Authors: Laia Bruni Ginesa Albero Jane Rowley Laia Alemany Marc Arbyn Anna R Giuliano Lauri E Markowitz Nathalie Broutet Melanie Taylor Source Type: research
First-line cemiplimab monotherapy and continued cemiplimab beyond progression plus chemotherapy for advanced non-small-cell lung cancer with PD-L1 50% or more (EMPOWER-Lung 1): 35-month follow-up from a mutlicentre, open-label, randomised, phase 3 trial
Lancet Oncol. 2023 Aug 14:S1470-2045(23)00329-7. doi: 10.1016/S1470-2045(23)00329-7. Online ahead of print.ABSTRACTBACKGROUND: Cemiplimab provided significant survival benefit to patients with advanced non-small-cell lung cancer with PD-L1 tumour expression of at least 50% and no actionable biomarkers at 1-year follow-up. In this exploratory analysis, we provide outcomes after 35 months' follow-up and the effect of adding chemotherapy to cemiplimab at the time of disease progression.METHODS: EMPOWER-Lung 1 was a multicentre, open-label, randomised, phase 3 trial. We enrolled patients (aged ≥18 years) with histologically ...
Source: Cancer Control - August 17, 2023 Category: Cancer & Oncology Authors: Mustafa Özgüroğlu Saadettin Kilickap Ahmet Sezer Mahmut G ümüş Igor Bondarenko Miranda Gogishvili Marina Nechaeva Michael Schenker Irfan Cicin Gwo Fuang Ho Yaroslav Kulyaba Kasimova Zyuhal Roxana-Ioana Scheusan Marina Chiara Garassino Xuanyao He Man Source Type: research
"Hi, How Can I Help You?" Embracing Artificial Intelligence in Kidney Research
Am J Physiol Renal Physiol. 2023 Aug 17. doi: 10.1152/ajprenal.00177.2023. Online ahead of print.ABSTRACTIn recent years, biology and precision medicine have benefited from the major advancements in generating large-scale molecular and biomedical datasets and in analyzing those data using advanced machine learning algorithms. Machine learning applications in kidney physiology and pathophysiology include segmenting kidney structures from imaging data and predicting conditions like acute kidney injury or chronic kidney disease using electronic health records. Despite the potential of machine learning to revolutionize nephrol...
Source: American Journal of Physiology. Renal Physiology - August 17, 2023 Category: Physiology Authors: Anita T Layton Source Type: research
Wellness Wheel Clinics: A First Nation community-partnered care model improving healthcare access, from healthcare providers' perspectives
Health Promot Int. 2023 Aug 1;38(4):daad079. doi: 10.1093/heapro/daad079.ABSTRACTFirst Nation people residing in rural and remote communities have limited primary healthcare access, which often affects chronic disease management leading to poor health outcomes. Individuals with lived experiences of chronic disease and substance use, along with health directors, advocated for improved services. Subsequently, an urban healthcare team in partnership with four First Nation communities developed an Outreach clinic to address healthcare access barriers. Established in 2016, this community-led clinic improves primary care access ...
Source: Rural Remote Health - August 17, 2023 Category: Rural Health Authors: Mamata Pandey Megan Clark Erin Beresh Solveig Nilson Cynthia Kay Trisha Campbell Susanne Nicolay Stuart Skinner Source Type: research
"Hi, How Can I Help You?" Embracing Artificial Intelligence in Kidney Research
Am J Physiol Renal Physiol. 2023 Aug 17. doi: 10.1152/ajprenal.00177.2023. Online ahead of print.ABSTRACTIn recent years, biology and precision medicine have benefited from the major advancements in generating large-scale molecular and biomedical datasets and in analyzing those data using advanced machine learning algorithms. Machine learning applications in kidney physiology and pathophysiology include segmenting kidney structures from imaging data and predicting conditions like acute kidney injury or chronic kidney disease using electronic health records. Despite the potential of machine learning to revolutionize nephrol...
Source: Am J Physiol Renal P... - August 17, 2023 Category: Urology & Nephrology Authors: Anita T Layton Source Type: research
Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model
EBioMedicine. 2023 Aug 14;95:104762. doi: 10.1016/j.ebiom.2023.104762. Online ahead of print.ABSTRACTBACKGROUND: Dolutegravir (DTG) is a recommended first-line regimen for all people with Human Immunodeficiency Virus (HIV) infection. Initial findings from Botswana, a country with no folate fortification program, showed an elevated prevalence of neural tube defects (NTDs) with peri-conceptional exposure to DTG. Here we explore whether a low folate diet influences the risk of DTG-associated foetal anomalies in a mouse model.METHODS: C57BL/6 mice fed a folate-deficient diet for 2 weeks, were mated and then randomly allocated ...
Source: Cancer Control - August 16, 2023 Category: Cancer & Oncology Authors: Haneesha Mohan Jessica Nguyen Ben MacKenzie Audrey Yee Evelyn Yukino Laurette Tanvi Sanghvi Oscar Tejada Valeriya Dontsova Kit-Yi Leung Cameron Goddard Taylor De Young John G Sled Nicholas D E Greene Andrew J Copp Lena Serghides Source Type: research
Greater executive dysfunction in patients post-COVID-19 compared to those not infected
Brain Behav Immun. 2023 Aug 14:S0889-1591(23)00237-4. doi: 10.1016/j.bbi.2023.08.014. Online ahead of print.ABSTRACTBACKGROUND: A number of patients post-coronavirus disease-19 (COVID-19) report cognitive impairment (CI), even months after acute infection. We aimed to assess if COVID-19 is associated with increased incidence of CI in comparison to controls.METHODS: We analyzed data from the Mount Sinai Health System Post-COVID-19 Registry in New York City, a prospective cohort of patients post-COVID-19 ≥18 years of age and non-infected controls. CI was defined by scores ≥1.0 standard deviation below population norms, a...
Source: Brain, Behavior, and Immunity - August 16, 2023 Category: Neurology Authors: Jacqueline H Becker Jenny J Lin Akosua Twumasi Ruchir Goswami Fernando Carnavali Kimberly Stone Monica Rivera-Mindt Minal S Kale Georges Naasan Joanne R Festa Juan P Wisnivesky Source Type: research
