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Minimally invasive procedures in gender-affirming care: the case for public funding across Canada
CMAJ. 2023 Aug 14;195(31):E1041-E1042. doi: 10.1503/cmaj.221875.NO ABSTRACTPMID:37580076 | PMC:PMC10426347 | DOI:10.1503/cmaj.221875
Source: cmaj - August 14, 2023 Category: General Medicine Authors: Katie Ross Sarah Fraser Source Type: research

Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome
J Clin Endocrinol Metab. 2023 Aug 15:dgad463. doi: 10.1210/clinem/dgad463. Online ahead of print.ABSTRACTSTUDY QUESTION: What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference?SUMMARY ANSWER: International evidence-based guidelines address prioritized questions and outcomes and include 254 recommendations and practice points, to promote consistent, evidence-based care and improve the experience and health outcomes in PCOS.WHAT IS KNOWN ALREADY: The 2018 International PCOS Guideline was independently ...
Source: The Journal of Clinical Endocrinology and Metabolism - August 14, 2023 Category: Endocrinology Authors: Helena J Teede Chau Thien Tay Joop J E Laven Anuja Dokras Lisa J Moran Terhi T Piltonen Michael F Costello Jacky Boivin Leanne M Redman Jacqueline A Boyle Robert J Norman Aya Mousa Anju E Joham International PCOS Network Source Type: research

Minimally invasive procedures in gender-affirming care: the case for public funding across Canada
CMAJ. 2023 Aug 14;195(31):E1041-E1042. doi: 10.1503/cmaj.221875.NO ABSTRACTPMID:37580076 | DOI:10.1503/cmaj.221875
Source: cmaj - August 14, 2023 Category: General Medicine Authors: Katie Ross Sarah Fraser Source Type: research

Sintilimab plus bevacizumab, oxaliplatin and capecitabine as first-line therapy in RAS-mutant, microsatellite stable, unresectable metastatic colorectal cancer: an open-label, single-arm, phase II trial
This study aims to assess the preliminary anti-tumor activity and safety of sintilimab plus bevacizumab, oxaliplatin and capecitabine as a treatment option for patients with RAS-mutant MSS mCRC.METHODS: This study was an open-label, single-arm, phase II trial in China. Patients with unresectable, RAS-mutant and MSS metastatic colorectal adenocarcinoma received treatment by intravenous sintilimab (200 mg, day 1) plus bevacizumab (7.5 mg/kg, day 1), oxaliplatin (135 mg/m2, day 1) and oral capecitabine (1 g/m2, day 1-14) in each 21-day cycle. The primary endpoints included objective response rate (ORR) and adverse events. Bio...
Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Xuefeng Fang Ning Zhu Chenhan Zhong Liuhong Wang Jun Li Shanshan Weng Hanguang Hu Caixia Dong Dan Li Yongmao Song Dong Xu Jianwei Wang Lifeng Sun Jian Wang Zhanhuai Wang Hongfeng Cao Xiujun Liao Ningjuan Yu Qian Xiao Mi Mi Suzhan Zhang Kefeng Ding Ying Yu Source Type: research

What does the historic settlement won by Henrietta Lacks ’s family mean for others?
Last week, the family of Henrietta Lacks settled its lawsuit against the huge biotechnology company Thermo Fisher Scientific over its claim that the company had been “unjustly enriched” by its use of her cells. Lacks was a Black woman who died of cervical cancer in 1951, soon after a doctor took a sample from her tumor without her knowledge or consent and created an immortal cell line, HeLa. No financial payments or other terms of the settlement were disclosed, and no judge ruled on the fundamentals of the unusual claim. But some have nevertheless hailed it as precedent setting. And the family ’ s la...
Source: Science of Aging Knowledge Environment - August 7, 2023 Category: Geriatrics Source Type: research

Gender-Based Research Underscores Sex Differences in Biological Processes, Clinical Disorders and Pharmacological Interventions
Biochem Pharmacol. 2023 Aug 5:115737. doi: 10.1016/j.bcp.2023.115737. Online ahead of print.ABSTRACTEarlier research has presumed that the male and female biology is similar in most organs except the reproductive system, leading to major misconceptions in research interpretations and clinical implications, with serious disorders being overlooked or misdiagnosed. Careful research has now identified sex differences in the cardiovascular, renal, endocrine, gastrointestinal, immune, nervous, and musculoskeletal systems. Also, several cardiovascular, immunological, and neurological disorders have shown differences in prevalence...
Source: Biochemical Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Sofia R Bernstein Caroline Kelleher Raouf A Khalil Source Type: research

Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis
We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.METHODS: Seven Study Contributors in Europe collected data on individuals aged ≥18 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed ≥14 days prior to symptom onset; no booster doses) or unvaccinated (...
Source: Herpes - August 7, 2023 Category: Infectious Diseases Authors: Wilhelmine Meeraus Leonie de Munter Christen M Gray Akshat Dwivedi Chlo é Wyndham-Thomas Mario Ouwens Wendy Hartig-Merkel Laura Drikite Griet Rebry Antonio Carmona Anke L Stuurman Thi Yen Chi Nguyen Guillermo Mena Ainara Mira-Iglesias Giancarlo Icardi Su Source Type: research

Optimal implementation of the 2019 ESC/EAS dyslipidaemia guidelines in patients with and without atherosclerotic cardiovascular disease across Europe: a simulation based on the DA VINCI study
Lancet Reg Health Eur. 2023 Jun 8;31:100665. doi: 10.1016/j.lanepe.2023.100665. eCollection 2023 Aug.ABSTRACTBACKGROUND: The impact of the stepwise implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) treatment algorithm on low-density lipoprotein cholesterol (LDL-C) goal attainment was simulated in patients from the DA VINCI study.METHODS: Monte Carlo simulation was used to evaluate treatment optimisation scenarios, based on a patient's risk category: statin intensification (step 1), addition of ezetimibe (step 2), and addition of a proprotein convertase subtilisin/kexin t...
Source: Atherosclerosis - August 7, 2023 Category: Cardiology Authors: Julia Brandts Sarah Bray Guillermo Villa Alberico L Catapano Neil R Poulter Antonio J Vallejo-Vaz Kausik K Ray DA VINCI study group Source Type: research

Gender-Based Research Underscores Sex Differences in Biological Processes, Clinical Disorders and Pharmacological Interventions
Biochem Pharmacol. 2023 Aug 5:115737. doi: 10.1016/j.bcp.2023.115737. Online ahead of print.ABSTRACTEarlier research has presumed that the male and female biology is similar in most organs except the reproductive system, leading to major misconceptions in research interpretations and clinical implications, with serious disorders being overlooked or misdiagnosed. Careful research has now identified sex differences in the cardiovascular, renal, endocrine, gastrointestinal, immune, nervous, and musculoskeletal systems. Also, several cardiovascular, immunological, and neurological disorders have shown differences in prevalence...
Source: Biochemical Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Sofia R Bernstein Caroline Kelleher Raouf A Khalil Source Type: research

Long-running ProMED email service for alerting world to disease outbreaks is in trouble
The first news about the COVID-19 pandemic came not from a government or a scientific publication, but in an email from a disease-alert system called ProMED . This fateful missive in December 2019 about a few cases of a mysterious pneumonia in Wuhan, China, is just one example of how physicians and public health experts around the world have used the 30-year-old, free service to share real-time information about local disease outbreaks with tens of thousands of subscribers. But ProMED is now on life support. Much of its work came to a screeching halt yesterday when 21 of its 38 paid editors and moderators went o...
Source: Science of Aging Knowledge Environment - August 4, 2023 Category: Geriatrics Source Type: research

A bone morphogenetic protein regulates the shell formation of Crassostrea gigas under ocean acidification
Gene. 2023 Aug 2:147687. doi: 10.1016/j.gene.2023.147687. Online ahead of print.ABSTRACTBone morphogenetic proteins (BMPs) are key factors controlling osteoblast differentiation, which have been proved to be involved in the hard tissue formation of marine mollusks. In the present study, a member of BMPs gene (CgBMP7) was identified from Pacific oyster Crassostrea gigas (C. gigas) with the aim to understand its possible role in the regulation of shell formation under ocean acidification (OA) conditions. The open reading frame (ORF) of CgBMP7 was of 1254 bp encoding a polypeptide of 417 amino acids. The deduced amino acid se...
Source: Gene - August 4, 2023 Category: Genetics & Stem Cells Authors: Yuqian Gao Zhaoqun Liu Ting Zhu Xiaoyu Xin Yuhao Jin Lingling Wang Chang Liu Linsheng Song Funding Source Type: research

Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study
Lancet Oncol. 2023 Aug;24(8):936-944. doi: 10.1016/S1470-2045(23)00298-X.ABSTRACTBACKGROUND: Retrospective studies have shown promising results using artificial intelligence (AI) to improve mammography screening accuracy and reduce screen-reading workload; however, to our knowledge, a randomised trial has not yet been conducted. We aimed to assess the clinical safety of an AI-supported screen-reading protocol compared with standard screen reading by radiologists following mammography.METHODS: In this randomised, controlled, population-based trial, women aged 40-80 years eligible for mammography screening (including general...
Source: Cancer Control - August 4, 2023 Category: Cancer & Oncology Authors: Kristina L ång Viktoria Josefsson Anna-Maria Larsson Stefan Larsson Charlotte H ögberg Hanna Sartor Solveig Hofvind Ingvar Andersson Aldana Rosso Source Type: research

A bone morphogenetic protein regulates the shell formation of Crassostrea gigas under ocean acidification
Gene. 2023 Aug 2:147687. doi: 10.1016/j.gene.2023.147687. Online ahead of print.ABSTRACTBone morphogenetic proteins (BMPs) are key factors controlling osteoblast differentiation, which have been proved to be involved in the hard tissue formation of marine mollusks. In the present study, a member of BMPs gene (CgBMP7) was identified from Pacific oyster Crassostrea gigas (C. gigas) with the aim to understand its possible role in the regulation of shell formation under ocean acidification (OA) conditions. The open reading frame (ORF) of CgBMP7 was of 1254 bp encoding a polypeptide of 417 amino acids. The deduced amino acid se...
Source: Gene - August 4, 2023 Category: Genetics & Stem Cells Authors: Yuqian Gao Zhaoqun Liu Ting Zhu Xiaoyu Xin Yuhao Jin Lingling Wang Chang Liu Linsheng Song Funding Source Type: research