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Infectious Disease: SARS

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Total 79986 results found since Jan 2013.

A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research

Rapid classification of SARS-CoV-2 variant strains using machine learning-based label-free SERS strategy
In this study, the label-free surface-enhanced Raman scattering (SERS) technology combined with machine learning (ML) algorithms provide a potential solution for accurate identification of SARS-CoV-2 variants. We establish a SERS spectral database of SARS-CoV-2 variants and demonstrate that a diagnostic classifier using a logistic regression (LR) algorithm can provide accurate results within 10 min. Our classifier achieves 100% accuracy for Beta (B.1.351/501Y.V2), Delta (B.1.617), Wuhan (COVID-19) and Omicron (BA.1) variants. In addition, our method achieves 100% accuracy in blind tests of positive and negative human nasal...
Source: Talanta - September 7, 2023 Category: Chemistry Authors: Jingwang Qin Xiangdong Tian Siying Liu Zhengxia Yang Dawei Shi Sihong Xu Yun Zhang Source Type: research

Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts' consensus statement updated for the Omicron variant
World J Pediatr. 2023 Sep 7. doi: 10.1007/s12519-023-00745-3. Online ahead of print.NO ABSTRACTPMID:37676610 | DOI:10.1007/s12519-023-00745-3
Source: World Journal of Pediatrics : WJP - September 7, 2023 Category: Pediatrics Authors: Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-X Source Type: research

Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research

Cycle Threshold Values as Indication of Increasing SARS-CoV-2 New Variants, England, 2020-2022
Emerg Infect Dis. 2023 Sep 7;29(10). doi: 10.3201/eid2910.230030. Online ahead of print.ABSTRACTEarly detection of increased infections or new variants of SARS-CoV-2 is critical for public health response. To determine whether cycle threshold (Ct) data from PCR tests for SARS-CoV-2 could serve as an early indicator of epidemic growth, we analyzed daily mean Ct values in England, UK, by gene target and used iterative sequential regression to detect break points in mean Ct values (and positive test counts). To monitor the epidemic in England, we continued those analyses in real time. During September 2020-January 2022, a tot...
Source: Emerging Infectious Diseases - September 7, 2023 Category: Infectious Diseases Authors: Rebecca E Harrison Ahmed Hamada Nujcharee Haswell Aigul Groves Karina-Doris Vihta Kerry Cella Sarah Garner Ann Sarah Walker Anna C Seale Source Type: research

First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.PMID:37676147 | DOI:10.2807/1560-7917.ES.2023.28.36.2300460
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Morten Rasmussen Frederik Trier M øller Vithiagaran Gunalan Sharmin Baig Marc Bennedb æk Lasse Engbo Christiansen Arieh Sierra Cohen Kirsten Ellegaard Anders Fomsgaard Kristina Tr æholt Franck Nicolai Balle Larsen Tine Graakj ær Larsen Ria Lassauni è Source Type: research

Aplastic anemia after SARS-CoV-2 infection or vaccines: case series and literature review
Blood Transfus. 2023 Sep 4. doi: 10.2450/BloodTransfus.500. Online ahead of print.NO ABSTRACTPMID:37677091 | DOI:10.2450/BloodTransfus.500
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Bruno Fattizzo Raffaella Pasquale Giorgio A Croci Loredana Pettine Giulio Cassanello Wilma Barcellini Source Type: research

First cases of SARS-CoV-2 BA.2.86 in Denmark, 2023
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate that the variant is circulating in the country at a low level. This new variant with many spike gene mutations was classified as a variant under monitoring by the World Health Organization on 17 August 2023. Further global monitoring of COVID-19, BA.2.86 and other SARS-CoV-2 variants is highly warranted.PMID:37676147 | DOI:10.2807/1560-7917.ES.2023.28.36.2300460
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Morten Rasmussen Frederik Trier M øller Vithiagaran Gunalan Sharmin Baig Marc Bennedb æk Lasse Engbo Christiansen Arieh Sierra Cohen Kirsten Ellegaard Anders Fomsgaard Kristina Tr æholt Franck Nicolai Balle Larsen Tine Graakj ær Larsen Ria Lassauni è Source Type: research

A standardised protocol for relative SARS-CoV-2 variant severity assessment, applied to Omicron BA.1 and Delta in six European countries, October 2021 to February 2022
In conclusion, this study demonstrates the feasibility of conducting variant severity analyses in a multinational collaborative framework and adds evidence for the reduced severity of the Omicron BA.1 variant.PMID:37676146 | DOI:10.2807/1560-7917.ES.2023.28.36.2300048
Source: Euro Surveill - September 7, 2023 Category: Infectious Diseases Authors: Tommy Nyberg Peter Bager Ingrid Bech Svalgaard Dritan Bejko Nick Bundle Josie Evans Tyra Grove Krause Jim McMenamin Jo ël Mossong Heather Mutch Ajibola Omokanye Andr é Peralta-Santos Pedro Pinto-Leite Jostein Starrfelt Simon Thelwall Lamprini Veneti Rob Source Type: research

COVID-19: An Overview of SARS-CoV-2 Variants-The Current Vaccines and Drug Development
Biomed Res Int. 2023 Aug 29;2023:1879554. doi: 10.1155/2023/1879554. eCollection 2023.ABSTRACTThe world is presently in crisis facing an outbreak of a health-threatening microorganism known as COVID-19, responsible for causing uncommon viral pneumonia in humans. The virus was first reported in Wuhan, China, in early December 2019, and it quickly became a global concern due to the pandemic. Challenges in this regard have been compounded by the emergence of several variants such as B.1.1.7, B.1.351, P1, and B.1.617, which show an increase in transmission power and resistance to therapies and vaccines. Ongoing researches are ...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Narjess Bostanghadiri Pardis Ziaeefar Morvarid Golrokh Mofrad Parsa Yousefzadeh Ali Hashemi Davood Darban-Sarokhalil Source Type: research

Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research