Personalised Transfusion Medicine.
PMID: 31385798 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - July 1, 2019 Category: Hematology Authors: D'Alessandro A, Liumbruno G Tags: Blood Transfus Source Type: research

Sex hormone intake in female blood donors: impact on haemolysis during cold storage and regulation of erythrocyte calcium influx by progesterone.
Abstract BACKGROUND: Sex hormone intake in blood donors may affect the quality of red blood cell (RBC) products via modulation of RBC function and predisposition to haemolysis during cold storage. The aims of this study were to evaluate the association between female sex hormone intake and RBC storage outcomes, and to examine possible mechanisms by which sex hormones interact with RBCs. MATERIALS AND METHODS: Sex hormone intake by race/ethnicity and menopausal status, and association analyses between hormone intake and donor scores of storage, osmotic or oxidative haemolysis, were evaluated in 6,636 female do...
Source: Blood Transfusion - July 1, 2019 Category: Hematology Authors: Fang F, Hazegh K, Sinchar D, Guo Y, Page GP, Mast AE, Kleinman S, Busch MP, Kanias T Tags: Blood Transfus Source Type: research

Donor Iron Deficiency Study (DIDS): protocol of a study to test whether iron deficiency in blood donors affects red blood cell recovery after transfusion.
CONCLUSION: This study will provide definitive evidence as to whether donor iron deficiency affects the quality of the blood supply and will assess the severity of symptoms affecting iron-deficient blood donors. PMID: 31385800 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - July 1, 2019 Category: Hematology Authors: Bitan ZC, Zhou A, McMahon DJ, Kessler D, Shaz BH, Caccappolo E, Schwartz J, Francis RO, Brittenham GM, Spitalnik SL, Hod EA Tags: Blood Transfus Source Type: research

Impact of G6PD status on red cell storage and transfusion outcomes.
Abstract There are inter-individual differences in the quality of refrigerator-stored red blood cells (RBCs). Possible sources of these variations include nutritional and genetic factors. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzyme deficiency worldwide that affects the ability of RBCs to respond to oxidative stress, has been implicated as a genetic factor that affects the quality of stored RBCs. This review considers the literature concerning G6PD-deficient RBCs. It discusses RBC unit variables such as in vitro storage, 24-hour post-transfusion recovery (PTR), post-transfusion survi...
Source: Blood Transfusion - July 1, 2019 Category: Hematology Authors: Karafin MS, Francis RO Tags: Blood Transfus Source Type: research

The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.
Abstract Reports from both adult and paediatric populations indicate that approximately two-thirds of platelet transfusions are used prophylactically to prevent bleeding, while the remaining one-third are used therapeutically to manage active bleeding. These two indications, prophylactic and therapeutic, serve two very distinct purposes and therefore will have two different functional requirements. In addition, disease aetiology in a given patient may require platelets with different functional characteristics. These characteristics can be derived from the various manufacturing methods used in platelet product pro...
Source: Blood Transfusion - July 1, 2019 Category: Hematology Authors: Shea SM, Thomas KA, Spinella PC Tags: Blood Transfus Source Type: research

Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?
Abstract Red blood cells (RBCs) have been historically regarded as a critical model to investigate cellular and oxidant stress biology. First of all, they are constantly exposed to oxidant stress, as their main function is to transport and deliver oxygen to tissues. Second, they are devoid of de novo protein synthesis capacity, which prevents RBCs from replacing irreversibly oxidised proteins with newly synthesised ones. As such, RBCs have evolved to (i) protect themselves from oxidant stress, in order to prevent oxidant damage from reactive species; (ii) repair oxidatively damaged proteins, through mechanisms tha...
Source: Blood Transfusion - June 6, 2019 Category: Hematology Authors: D'Alessandro A, Hansen KC, Eisenmesser EZ, Zimring JC Tags: Blood Transfus Source Type: research

Genetic testing to resolve the source of haemolytic antibody in solid organ transplantation.
DISCUSSION: Passenger lymphocyte syndrome after mismatched organ transplantation is not rare, but the syndrome associated with non-ABO antibodies occurs in a much smaller subset of these cases. The mixtures of organ donor, recipient, and other transfused red blood cells profoundly limit the usefulness of serological testing. Genetic assignment of minor blood types to donor and recipient can guide therapy and inform prognosis. PMID: 31184578 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 5, 2019 Category: Hematology Authors: Tsang HC, Samraj AN, Morse RJ, Krumm N, Hess JR, Pagano MB Tags: Blood Transfus Source Type: research

Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine.
PMID: 31184580 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 5, 2019 Category: Hematology Authors: Kanias T, Busch MP, National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Programme Tags: Blood Transfus Source Type: research

Physical activity improved by adherence to prophylaxis in an Italian population of children, adolescents and adults with severe haemophilia A: the SHAPE Study.
DISCUSSION: PWH with better orthopaedic scores reported better physical performance. Adherence to long-term prophylaxis proved to be high and correlated with a reduction in bleeds, target joints, school/work days lost, and with a performance improvement in endurance sports activities over time. PMID: 31184581 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 5, 2019 Category: Hematology Authors: Zanon E, Tagliaferri A, Pasca S, Ettorre CP, Notarangelo LD, Biasioli C, Aru AB, Milan M, Linari S, Rocino A, Gagliano F, Di Minno G, Gamba G, Santoro RC, Schinco P, Marietta M, Seuser A, von Mackensen S Tags: Blood Transfus Source Type: research

30 º Congreso de la Sociedad Española de Transfusión Sanguínea y Terapia Celular (SETS), Madrid (España), 6-8 Junio 2019.
30º Congreso de la Sociedad Española de Transfusión Sanguínea y Terapia Celular (SETS), Madrid (España), 6-8 Junio 2019. Blood Transfus. 2019 Jun 04;17(Supplement no. 3):s201-s406 Authors: Llorente AV, Velasco JA, Llobet AB, Alonso MÁC, Pajares Herraiz ÁL, Del Rio Garma J, Rodríguez Gambarte JD, Ustazo EA PMID: 31166166 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 4, 2019 Category: Hematology Authors: Llorente AV, Velasco JA, Llobet AB, Alonso MÁC, Pajares Herraiz ÁL, Del Rio Garma J, Rodríguez Gambarte JD, Ustazo EA Tags: Blood Transfus Source Type: research

VI Conferenza Nazionale dei Servizi Trasfusionali, Rimini, 9-11 maggio 2019.
PMID: 31009593 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - April 10, 2019 Category: Hematology Authors: Berti P, Aprili G, Bennardello F, Coluzzi S, Curciarello G, Di Gregorio P, Facco G, Fiorin F, Gandini G, Garozzo G, Nocera C, Velati C, Visceglie D Tags: Blood Transfus Source Type: research

6th International Multidisciplinary Course on Iron Deficiency, Lisbon (Portugal), 13-14 April 2018.
;oz M PMID: 30917098 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - March 25, 2019 Category: Hematology Authors: Muñoz M Tags: Blood Transfus Source Type: research

Viral safety of APOSEC ™: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine.
DISCUSSION: Three manufacturing steps of APOSEC™ were evaluated under Good Laboratory Practice conditions for their efficacy at reducing and inactivating potentially present viruses. It could be demonstrated that all three steps contribute to the viral safety of APOSEC™. PMID: 30865581 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - February 21, 2019 Category: Hematology Authors: Gugerell A, Sorgenfrey D, Laggner M, Raimann J, Peterbauer A, Bormann D, Suessner S, Gabriel C, Moser B, Ostler T, Mildner M, Ankersmit HJ Tags: Blood Transfus Source Type: research

Transfusion-transmissible infections among Serbian blood donors: declining trends over the period 2005-2017.
This study reports the prevalence of TTIs among blood donors in Serbia in the period 2005-2017. MATERIALS AND METHODS: Between January 2005 and December 2017, in the four largest Serbian transfusion centres, mandatory serology tests for screening HBV, HCV, HIV and syphilis infection were used for all blood donations. RESULTS: Of the total of 1,660,019 blood donations made, 3,377 (0.203%) were positive for one of the TTIs: 1,440 (0.087%), 1,055 (0.064%), 215 (0.013%), and 667 (0.040%) were positive for HBV, HCV, HIV and syphilis, respectively. Serbia showed a declining trend of prevalence of HBV and HCV infection,...
Source: Blood Transfusion - February 19, 2019 Category: Hematology Authors: Vučetić D, Jovičić M, Maslovarić I, Bogdanović S, Antić A, Stanojković Z, Filimonović G, Ilić V Tags: Blood Transfus Source Type: research

Effects of micronised microencapsulated ferric pyrophosphate supplementation in patients with advanced cancer and iron deficiency: a single-centre cohort pilot study.
DISCUSSION: The supplementation of 30 mg/d of MMFP in combination with 80 mg/d of ascorbic acid in advanced cancer patients with hyposideraemia led to a significant increase in sideraemia and ferritinaemia. Moreover, in some of the patients whose serum iron level did not increase, an increase in haemoglobin was observed. PMID: 30865583 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - February 18, 2019 Category: Hematology Authors: Pappalardo A, Currenti W, Ponzio R, Mellini G, Nicolosi D, Longhitano L, Tibullo D, Castorina S, Palumbo G Tags: Blood Transfus Source Type: research

New data from the Italian National Register of Congenital Coagulopathies, 2016 Annual Survey.
DISCUSSION: The prevalences of HA and HB fall within the ranges reported in more developed countries; the consumption of FVIII and FIX was in line with that of other European countries (France, United Kingdom) and Canada. The NRCC, with its bleeding disorder dataset, is a helpful tool for shaping public health policies, as well as planning clinical and epidemiological research projects. PMID: 30865582 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - February 13, 2019 Category: Hematology Authors: Abbonizio F, Hassan HJ, Riccioni R, Santagostino E, Arcieri R, Giampaolo A, Italian Association of Haemophilia Centres (see Appendix) Tags: Blood Transfus Source Type: research

Malaria blood safety policy in five non-endemic countries: a retrospective comparison through the lens of the ABO risk-based decision-making framework.
DISCUSSION: The assessments considered in each country were generally consistent with the assessments recommended by the Framework. When data supported quantified risk assessment, safety and operational feasibility had the greatest weight. When risk was not well defined, contextual factors such as social and political concern had greater weight. PMID: 30865584 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - February 6, 2019 Category: Hematology Authors: O'Brien SF, Ward S, Gallian P, Fabra C, Pillonel J, Kitchen AD, Davison K, Seed CR, Delage G, Steele WR, Leiby DA Tags: Blood Transfus Source Type: research

Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement.
dy JF Abstract Patient blood management (PBM) is the timely application of evidence-informed medical and surgical concepts designed to maintain haemoglobin concentration, optimise haemostasis, and minimise blood loss in an effort to improve patient outcomes. The aim of this consensus statement is to provide recommendations on the prevention and treatment of postpartum haemorrhage as part of PBM in obstetrics. A multidisciplinary panel of physicians with expertise in obstetrics, anaesthesia, haematology, and transfusion medicine was convened by the Network for the Advancement of Patient Blood Management, Haemostasi...
Source: Blood Transfusion - February 6, 2019 Category: Hematology Authors: Muñoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, Goffinet F, Hofer S, Holzgreve W, Manrique S, Nizard J, Christory F, Samama CM, Hardy JF Tags: Blood Transfus Source Type: research

Position paper on laboratory testing for patients with haemophilia. A consensus document from SISET, AICE, SIBioC and SIPMeL.
PMID: 30747702 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Tripodi A, Santoro RC, Testa S, Molinari AC, Bernardini S, Golato M, Lippi G, Ageno W, Santagostino E Tags: Blood Transfus Source Type: research

Telemedicine and telerehabilitation: current and forthcoming applications in haemophilia.
Abstract In persons with haemophilia (PWH), the importance of comprehensive disease management to prevent bleeding, joint damage and secondary diseases has been well established. However, because haemophilia is a chronic disease, intervention programmes carried out for prolonged periods of time may create problems of patient adherence. Driven by continuous technological innovation, telemedicine is being increasingly proposed as a way to provide PWH with a range of services designed to improve their health, saving the time and cost involved in going to the treatment centre, and increasing therapeutic adherence. The...
Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Boccalandro EA, Dallari G, Mannucci PM Tags: Blood Transfus Source Type: research

Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product utilisation.
Abstract BACKGROUND: Increased systemic fibrinolytic activity can occur in liver transplant recipients after the donor graft is reperfused. However, it remains unclear whether this is related solely to tissue plasminogen activator (t-PA) levels or whether unique metabolic changes can alter t-PA activity and enhance fibrinolytic activity. We hypothesise that an increase in sensitivity to t-PA-mediated fibrinolysis (StF) following liver reperfusion is associated with specific metabolic abnormalities. MATERIALS AND METHODS: Liver transplant recipients had serial blood samples analysed with a modified thrombelast...
Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Moore HB, D'alessandro A, Moore EE, Wither M, Lawson PJ, Huebner BR, Hansen K, Choudhury R, Nydam TL Tags: Blood Transfus Source Type: research

Intracranial haemorrhage in children and adults with haemophilia A and B: a literature review of the last 20 years.
Abstract Intracranial haemorrhage (ICH) is the most serious event in haemophiliacs, resulting in high rates of mortality and disability. Although the use of a prophylaxis regimen has improved outcomes, the mortality caused by ICH is still around 20%. ICH is more frequent at two different ages: in childhood (mostly in children aged ≤2 years) and in adulthood (with known risk factors such as hypertension and age ≥60 years). Our review shows how ICH remains one of the worst problems of patients with haemophilia. Greater attention to risk factors and early symptoms, together with an appropriate early prophylaxis...
Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Zanon E, Pasca S Tags: Blood Transfus Source Type: research

A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease.
derici AB Abstract BACKGROUND: There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT). MATERIALS AND METHODS: In this 12-month, phase III, open-label study (PRO.WILL), vWD patients (aged ≥6 years) were randomised to PRO (n=9; 5 completed) or ODT (n=10; 7 completed...
Source: Blood Transfusion - February 4, 2019 Category: Hematology Authors: Peyvandi F, Castaman G, Gresele P, De Cristofaro R, Schinco P, Bertomoro A, Morfini M, Gamba G, Barillari G, Jiménez-Yuste V, Königs C, Iorio A, Federici AB Tags: Blood Transfus Source Type: research

Effects of in-house cryoprecipitate on transfusion usage and mortality in patients with multiple trauma with severe traumatic brain injury: a retrospective cohort study.
Abstract BACKGROUND: Hypofibrinogenaemia is a common complication of multiple trauma with severe traumatic brain injury (Abbreviated Injury Scale score of the head ≥4; body ≥3). In Japan, neither fibrinogen concentrate nor cryoprecipitate is permitted to treat acquired hypofibrinogenaemia with the purpose of rapidly restoring a haemostatic level of fibrinogen. The aim of this study was to investigate transfusion usage and mortality in patients with multiple trauma and severe traumatic brain injury who were given a cryoprecipitate prepared in-house, comparing those administered the product early or later. ...
Source: Blood Transfusion - January 22, 2019 Category: Hematology Authors: Sugiyama K, Fujita H, Nishimura S Tags: Blood Transfus Source Type: research

Hitchhiker's guide to the red blood cell storage lesion.
PMID: 30653457 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - January 1, 2019 Category: Hematology Authors: Thomas T, Spitalnik SL Tags: Blood Transfus Source Type: research

Red blood cell alloimmunisation in transfusion-dependent thalassaemia: a systematic review.
DISCUSSION: Matching transfusion-dependent thalassaemia patients and red blood cell units for Rh and Kell antigens should be able to reduce the risk of red blood cell alloimmunisation by about 80%. PMID: 30653458 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - January 1, 2019 Category: Hematology Authors: Franchini M, Forni GL, Marano G, Cruciani M, Mengoli C, Pinto V, De Franceschi L, Venturelli D, Casale M, Amerini M, Capuzzo M, Grazzini G, Masiello F, Pati I, Veropalumbo E, Vaglio S, Pupella S, Liumbruno GM Tags: Blood Transfus Source Type: research

Red blood cell storage lesion: causes and potential clinical consequences.
Abstract Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen directly from ambient air via diffusion, thereby fueling oxidative phosphorylation for highly efficient energy production. RBCs have evolved to optimally serve this purpose by packing high concentrations of haemoglobin in their cytosol and shedding nuclei and other organelles. During their circulatory lifetimes in humans of approximately 120 days, RBCs are poised to transport oxygen by metabolic/redox enzymes until they accumul...
Source: Blood Transfusion - January 1, 2019 Category: Hematology Authors: Yoshida T, Prudent M, D'alessandro A Tags: Blood Transfus Source Type: research

Fibrinogen measurement in liver disease: validation of the functional fibrinogen thromboelastography assay and a novel mathematical predictive model.
DISCUSSION: The results of the FF-TEG correlate well with those of routine fibrinogen assays in patients with liver cirrhosis. However, the FF-TEG assay does not discriminate between early and late stages of disease, pointing to a preserved fibrin clot strength in cirrhosis. Through linear regression models, fibrinogen levels can be accurately estimated using the Clauss method based on fibrinogen levels obtained in the cheaper PT-Fg. PMID: 30418134 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - November 9, 2018 Category: Hematology Authors: Rizzo K, Vella K, Zammit D, Gatt P, Grima C, Inguanez MB, Gerada J, Ellul P, Vassallo M, Azzopardi N, Pocock J, Gatt A Tags: Blood Transfus Source Type: research

Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.
DISCUSSION: Transfused platelets serve as an adjuvant in this T-dependent murine model of anti-KEL red blood cell alloimmunisation, with CD40/CD40L interactions being involved to some degree but with additional mechanisms also playing a role. These findings raise questions about the role that transfused or endogenous platelets may play in other innate/adaptive immune responses. PMID: 30418129 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - November 7, 2018 Category: Hematology Authors: Madrid DJ, Santhanakrishnan M, Liu J, Gibb DR, Liu D, Natarajan P, Beitler D, Shi Z, Mo C, Tormey CA, Patel SR, Stowell SR, Hendrickson JE Tags: Blood Transfus Source Type: research

Cost of pathogen reduction for platelets: reply to Cicchetti et al. Blood Transfus 2018; 16: 483-9.
PMID: 30418132 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - November 7, 2018 Category: Hematology Authors: Farrugia A Tags: Blood Transfus Source Type: research

XXV Congresso Nazionale della Societ à Italiana per lo Studio dell'Emostasi e della Trombosi (SISET).
XXV Congresso Nazionale della Società Italiana per lo Studio dell'Emostasi e della Trombosi (SISET). Blood Transfus. 2018 Nov 07;16(Supplement no. 4):s415-s562 Authors: Ageno W, Falanga A, Castaman G PMID: 30412048 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - November 7, 2018 Category: Hematology Authors: Ageno W, Falanga A, Castaman G Tags: Blood Transfus Source Type: research

The key role of tranexamic acid in Patient Blood Management programmes.
PMID: 30388070 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - November 1, 2018 Category: Hematology Authors: Franchini M, Liumbruno GM Tags: Blood Transfus Source Type: research

Efficacy of platelet-rich plasma as conservative treatment in orthopaedics.
PMID: 30388071 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - November 1, 2018 Category: Hematology Authors: Clendenen N, Ginde A Tags: Blood Transfus Source Type: research

Influence of apheresis collection device and container on the storage properties of platelets in 90% PAS-5/10% plasma.
DISCUSSION: Storage of platelets suspended in PAS-5 with 10% plasma is feasible in the original manufacturer's container for seven days. Based on CO2 levels, T containers have greater gas exchange than A containers. PMID: 30201085 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - September 5, 2018 Category: Hematology Authors: Wagner SJ, Hapip CA, Turgeon A, Abel L, Kaelber N Tags: Blood Transfus Source Type: research

Budget impact of implementing platelet pathogen reduction into the Italian blood transfusion system.
DISCUSSION: In order to fully evaluate the societal perspective of implementing platelet PRT, the increase in costs must be balanced against the expected benefits (prevention of transfusion-transmissible infections, white cell inactivation, extension of platelet storage, discontinuation of pathogen detection testing). Further studies based on actual numbers of platelet transfusion complications and their societal cost at a local level are needed to see the full cost to benefit ratio of platelet PRT implementation in Italy, and to promote equal treatment for all citizens. PMID: 30201081 [PubMed - as supplied by publish...
Source: Blood Transfusion - September 3, 2018 Category: Hematology Authors: Cicchetti A, Coretti S, Sacco F, Rebulla P, Fiore A, Rumi F, Di Bidino R, Urbina LI, Refolo P, Sacchini D, Spagnolo AG, Midolo E, Marano G, Farina B, Pati I, Veropalumbo E, Pupella S, Liumbruno GM Tags: Blood Transfus Source Type: research

Efficacy of platelet-rich plasma as conservative treatment in orthopaedics: a systematic review and meta-analysis.
CONCLUSIONS: The results of this meta-analysis, which documents the very marginal effectiveness of PRP compared to controls, does not support the use of PRP as conservative treatment in orthopaedics. PMID: 30201082 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - September 3, 2018 Category: Hematology Authors: Franchini M, Cruciani M, Mengoli C, Marano G, Pupella S, Veropalumbo E, Masiello F, Pati I, Vaglio S, Liumbruno GM Tags: Blood Transfus Source Type: research

Efficacy of topical tranexamic acid within a blood-saving programme for primary total hip arthroplasty: a pragmatic, open-label randomised study.
This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe. MATERIALS AND METHODS: A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted. Consecutive patients were randomly assigned to receive topical tranexamic acid (2 g) at the end of surgery (tranexamic group, n=125) or not (control group, n=129). A restrictive transfusion protocol was applied. Outcome measures were red blood cell loss at 24 hours after surgery, in-hospital tr...
Source: Blood Transfusion - September 3, 2018 Category: Hematology Authors: Pérez-Jimeno N, Muñoz M, Mateo J, Mayoral AP, Herrera A Tags: Blood Transfus Source Type: research

Factors affecting the quality, safety and marketing approval of clotting factor concentrates for haemophilia.
Abstract Selecting therapeutic products for the treatment of haemophilia follows the process of obtaining market approval of products submitted to the scrutiny of a regulatory agency. In well-resourced countries, key decisions on whether a product is sufficiently safe and of high quality are made by highly expert and well-resourced agencies, such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In countries lacking such agencies, well-informed decisions can still be made through an appreciation of the key issues affecting the quality, safety and efficacy of haemophilia products...
Source: Blood Transfusion - September 3, 2018 Category: Hematology Authors: Farrugia A, Liumbruno GM, Candura F, Profili S, Cassar J Tags: Blood Transfus Source Type: research

Molecular genetic analysis of weak ABO subgroups in the Chinese population reveals ten novel ABO subgroup alleles.
CONCLUSION: Ten novel weak ABO subgroup alleles were identified in the Chinese population. GTA mutant p.L339P may lead to a weak A phenotype by changing the local conformation of GTA and reducing its stability. PMID: 30201086 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - September 3, 2018 Category: Hematology Authors: Huang H, Jin S, Liu X, Wang Z, Lu Q, Fan L, Shen W, Lei H, Qian C, Wang X, Xiang D, Cai X Tags: Blood Transfus Source Type: research

Blood safety policy: should cautionary policies be adopted with caution?
PMID: 30183614 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - September 1, 2018 Category: Hematology Authors: Riva L, Petrini C Tags: Blood Transfus Source Type: research

Intravenous immunoglobulin replacement treatment reduces in vivo elastase secretion in patients with common variable immune disorders.
This study was focused on the evaluation of the effects of in vivo IVIg administration on neutrophils from patients with common variable immune disorders (CVID). We examined polymorphonuclear neutrophil (PMN) phagocytosis, PMN oxidative burst, release of neutrophil elastase, serum level of interleukin-8 and PMN expression of CXCR1, CD11c and CD66b. RESULTS: CVID patients on chronic IVIg treatment had reduced elastase release, but normal expression of CXCR1, CD66b and CD11c receptors on PMN, normal phagocytic ability and normal secretion of interleukin-8. We found that IVIg infusions rapidly reduced the serum level of ...
Source: Blood Transfusion - July 17, 2018 Category: Hematology Authors: Prezzo A, Cavaliere FM, Milito C, Bilotta C, Iacobini M, Quinti I Tags: Blood Transfus Source Type: research

Experience with RHD*weak D type 4.0 in the USA.
PMID: 30036180 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - July 6, 2018 Category: Hematology Authors: Westhoff CM, Nance S, Lomas-Francis C, Keller M, Chou ST Tags: Blood Transfus Source Type: research

Cost-effectiveness analysis of ferric carboxymaltose in pre-operative haemoglobin optimisation in patients undergoing primary knee arthroplasty.
DISCUSSION: In primary knee arthroplasty, pre-operative haemoglobin optimisation with intravenous ferric carboxymaltose is less expensive than other reported patient blood management modalities and must be considered in patients with iron deficiency anaemia. PMID: 30036177 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 26, 2018 Category: Hematology Authors: Basora M, Pereira A, Coca M, Tió M, Lozano L Tags: Blood Transfus Source Type: research

Prevalence, incidence and residual risk of transfusion-transmitted hepatitis C virus and human immunodeficiency virus after the implementation of nucleic acid testing in Italy: a 7-year (2009-2015) survey.
DISCUSSION: HCV infection has declined over time in both first-time and repeat donors, while the data for HIV infection are stable. All three methods employed in this study showed that the residual risk of transmitting HCV or HIV through an infected blood unit is currently very low in Italy, but there are considerable differences in estimates between methods. Thus, harmonisation of these methods is advisable. PMID: 30036178 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 26, 2018 Category: Hematology Authors: Velati C, Romanò L, Piccinini V, Marano G, Catalano L, Pupella S, Facco G, Pati I, Tosti ME, Vaglio S, Grazzini G, Zanetti A, Liumbruno GM Tags: Blood Transfus Source Type: research

Predicting factors for liver iron overload at the first magnetic resonance in children with thalassaemia major.
CONCLUSION: In order to prevent liver iron overload at the first MRI, children should maintain a stable level of serum ferritin below 1,770 from the start of chelation therapy. However, strict monitoring of growth is mandatory. PMID: 30036179 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - June 26, 2018 Category: Hematology Authors: Casale M, Marsella M, Ammirabile M, Spasiano A, Costantini S, Cinque P, Ricchi P, Filosa A Tags: Blood Transfus Source Type: research

43 ° Convegno Nazionale di Studi di Medicina Trasfusionale, Genova, 23-25 maggio 2018.
43° Convegno Nazionale di Studi di Medicina Trasfusionale, Genova, 23-25 maggio 2018. Blood Transfus. 2018 May 23;16(Supplement no. 1):s3-s234 Authors: Berti P, Bennardello F, Coluzzi S, Di Gregorio P, Facco G, Fiorin F, Velati C, Visceglie D PMID: 29792592 [PubMed - in process] (Source: Blood Transfusion)
Source: Blood Transfusion - May 23, 2018 Category: Hematology Authors: Berti P, Bennardello F, Coluzzi S, Di Gregorio P, Facco G, Fiorin F, Velati C, Visceglie D Tags: Blood Transfus Source Type: research

Reversal of apixaban induced alterations in haemostasis by different coagulation factor concentrates in patients after hip or knee replacement surgery.
rber MK Abstract BACKGROUND: Apixaban is a direct oral anticoagulant (DOAC) with a specific inhibition of activated factor X (FXa). In case of bleeding or need of urgent surgery a direct antidote is not yet available. Off-label application of non-specific haemostatic agents, such as prothrombin complex concentrate (PCC) and recombinant FVIIa (rFVIIa), has been reported to reverse the effects of apixaban in in vitro and animal studies. The aim of this study is to measure the reversal potential of PCC and rFVIIa in patients with prophylactic apixaban concentrations. MATERIAL AND METHODS: Whole blood from patien...
Source: Blood Transfusion - May 11, 2018 Category: Hematology Authors: Schmidt K, Krüger K, Langer E, Schmutzler M, Johnen E, Wernecke KD, Von Heymann C, Körber MK Tags: Blood Transfus Source Type: research

Haemolysis index for the screening of intravascular haemolysis: a novel diagnostic opportunity?
Abstract The diagnostic approach to patients with intravascular haemolysis remains challenging, since no first-line laboratory test seems to be entirely suitable for the screening of this condition. Recent evidence shows that an enhanced cell-free haemoglobin (fHb) concentration in serum or plasma is a reliable marker of red blood cell injury, and may also predict clinical outcomes in patients with different forms of haemolytic anaemias. However, the routine use of the haemiglobincyanide assay, the current reference method for measuring fHb, seems unsuitable for a timely diagnosis of intravascular haemolysis, for ...
Source: Blood Transfusion - May 8, 2018 Category: Hematology Authors: Lippi G, Favaloro EJ, Franchini M Tags: Blood Transfus Source Type: research

A nationwide retrospective study on prevalence of hepatitis E virus infection in Italian blood donors.
DISCUSSION: The detected IgG rate of 8.7% in this study represents one of the lowest seroprevalence rates reported among blood donors in Europe. Particularly high prevalence rates in some regions and provinces may be explained by local eating habits and/or intensive environmental HEV contamination. Before considering the introduction of HEV RNA screening for blood donations in Italy, further important issues should be addressed and prospective incidence and reliable cost-benefit studies are needed. PMID: 29757135 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - May 4, 2018 Category: Hematology Authors: Spada E, Pupella S, Pisani G, Bruni R, Chionne P, Madonna E, Villano U, Simeoni M, Fabi S, Marano G, Marcantonio C, Pezzotti P, Ciccaglione AR, Liumbruno GM Tags: Blood Transfus Source Type: research

Tranexamic acid to prevent post-partum haemorrhage.
PMID: 29757130 [PubMed - as supplied by publisher] (Source: Blood Transfusion)
Source: Blood Transfusion - May 3, 2018 Category: Hematology Authors: Van Der Linde R, Favaloro EJ Tags: Blood Transfus Source Type: research