Filtered By:
Drug: Methotrexate
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 5114 results found since Jan 2013.
Therapeutic Effect of Colony Stimulating Factor 1 Receptor Kinase Inhibitor, JTE-952, on Methotrexate-Refractory Pathology in a Rat Model of Rheumatoid Arthritis
Biol Pharm Bull. 2023;46(9):1223-1230. doi: 10.1248/bpb.b23-00148.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and the destruction of bone and cartilage in affected joints. One of the unmet medical needs in the treatment of RA is to effectively prevent the structural destruction of joints, especially bone, which progresses because of resistance to conventional drugs that mainly have anti-inflammatory effects, and directly leads to a decline in the QOL of patients. We previously developed a novel and orally available type II kinase inhibitor of colony-stimulating factor-1 receptor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Naofumi Uesato Yoshihiro Kitagawa Yushi Matsuo Naoki Miyagawa Koji Inagaki Reina Kakefuda Takayuki Yamaguchi Takahiro Hata Kazutaka Ikegashira Mutsuyoshi Matsushita Source Type: research
Nephroprotective effects of < em > Datura stramonium < /em > leaves against methotrexate nephrotoxicity via attenuation of oxidative stress-mediated inflammation and apoptosis in rats
CONCLUSION: DSLE has nephroprotective activity against MTX toxicity. However, further mechanistic studies are needed.PMID:37663387 | PMC:PMC10474919 | DOI:10.22038/AJP.2023.21903
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Esther U Alum Ademola C Famurewa Obasi U Orji Patrick M Aja Felix Nwite Simon E Ohuche Stanley C Ukasoanya Lucy O Nnaji Deborah Joshua Kingsley U Igwe Stephen F Chima Source Type: research
Therapeutic Effect of Colony Stimulating Factor 1 Receptor Kinase Inhibitor, JTE-952, on Methotrexate-Refractory Pathology in a Rat Model of Rheumatoid Arthritis
Biol Pharm Bull. 2023;46(9):1223-1230. doi: 10.1248/bpb.b23-00148.ABSTRACTRheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and the destruction of bone and cartilage in affected joints. One of the unmet medical needs in the treatment of RA is to effectively prevent the structural destruction of joints, especially bone, which progresses because of resistance to conventional drugs that mainly have anti-inflammatory effects, and directly leads to a decline in the QOL of patients. We previously developed a novel and orally available type II kinase inhibitor of colony-stimulating factor-1 receptor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Naofumi Uesato Yoshihiro Kitagawa Yushi Matsuo Naoki Miyagawa Koji Inagaki Reina Kakefuda Takayuki Yamaguchi Takahiro Hata Kazutaka Ikegashira Mutsuyoshi Matsushita Source Type: research
Effectiveness and tolerability of methotrexate monotherapy in Crohn's disease patients: a multicenter observational study
CONCLUSIONS: Methotrexate monotherapy was effective and tolerable as a maintenance therapy in CD patients.PMID:37655055 | PMC:PMC10467270 | DOI:10.1177/17562848231191664
Source: Adv Data - September 1, 2023 Category: Epidemiology Authors: Jihye Park Jaeyoung Chun Soo Jung Park Jae Jun Park Tae Il Kim Hyuk Yoon Jae Hee Cheon Source Type: research
Efficacy and safety of tripterygium wilfordii Hook F plus TNF inhibitor for active rheumatoid arthritis: A multicentre, randomized, double-blind, triple-dummy controlled trial
Clin Immunol. 2023 Aug 30:109749. doi: 10.1016/j.clim.2023.109749. Online ahead of print.ABSTRACTAn investigator-initiated, multicentre, randomized, double-blind, triple-dummy, controlled trial was conducted at 14 tertiary rheumatology centers in China to evaluate the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with recombinant human TNF receptor IgGFc fusion protein (rhTNFR-Fc) in active Rheumatoid Arthritis (RA). Primary endpoint was the proportion of patients achieved a 50% improvement of American College of Rheumatology criteria (ACR50) in TwHF+rhTNFR-Fc vs. methotrexate (MTX) group at week 12. ACR50 wa...
Source: Clinical Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Huaxia Yang Xiaoxia Zuo Lijun Wu Jiangyun Peng Zhenbin Li Hongbin Li Wei Ji Liyun Zhang Xiaomei Li Lie Dai Liangjing Lu Niansheng Yang Wei Wei Zongwen Shuai Ying Jiang Yudong Liu Peter E Lipsky Hua Chen YISTAR study group Source Type: research
Network pharmacology analysis and clinical verification of Jishe Qushi capsules in rheumatoid arthritis treatment
Medicine (Baltimore). 2023 Aug 25;102(34):e34883. doi: 10.1097/MD.0000000000034883.ABSTRACTThe study aimed to elucidate the effective chemical composition and molecular mechanism of rheumatoid arthritis (RA) treatment with Jishe Qushi capsules (JSQS) and perform clinical validation. The effective chemical components were screened by a database. We used Cytoscape software to construct the key target-RA composite target network of JSQS. Gene Ontology biofunctional analysis and Kyoto encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed for the key targets, followed by molecular docking validatio...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Yujie Li Nannan Zhang Xin Peng Wukai Ma Yuanxing Qin Xueming Yao Cong Huang Xudong Zhang Source Type: research
Effectiveness and tolerability of methotrexate monotherapy in Crohn's disease patients: a multicenter observational study
CONCLUSIONS: Methotrexate monotherapy was effective and tolerable as a maintenance therapy in CD patients.PMID:37655055 | PMC:PMC10467270 | DOI:10.1177/17562848231191664
Source: Adv Data - September 1, 2023 Category: Epidemiology Authors: Jihye Park Jaeyoung Chun Soo Jung Park Jae Jun Park Tae Il Kim Hyuk Yoon Jae Hee Cheon Source Type: research
Efficacy and safety of tripterygium wilfordii Hook F plus TNF inhibitor for active rheumatoid arthritis: A multicentre, randomized, double-blind, triple-dummy controlled trial
Clin Immunol. 2023 Aug 30:109749. doi: 10.1016/j.clim.2023.109749. Online ahead of print.ABSTRACTAn investigator-initiated, multicentre, randomized, double-blind, triple-dummy, controlled trial was conducted at 14 tertiary rheumatology centers in China to evaluate the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with recombinant human TNF receptor IgGFc fusion protein (rhTNFR-Fc) in active Rheumatoid Arthritis (RA). Primary endpoint was the proportion of patients achieved a 50% improvement of American College of Rheumatology criteria (ACR50) in TwHF+rhTNFR-Fc vs. methotrexate (MTX) group at week 12. ACR50 wa...
Source: Clinical Immunology - September 1, 2023 Category: Allergy & Immunology Authors: Xuan Zhang Huaxia Yang Xiaoxia Zuo Lijun Wu Jiangyun Peng Zhenbin Li Hongbin Li Wei Ji Liyun Zhang Xiaomei Li Lie Dai Liangjing Lu Niansheng Yang Wei Wei Zongwen Shuai Ying Jiang Yudong Liu Peter E Lipsky Hua Chen YISTAR study group Source Type: research
Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential
ChemMedChem. 2023 Aug 29:e202300184. doi: 10.1002/cmdc.202300184. Online ahead of print.ABSTRACTIn this work, a new set of quinazolin-2,4,6-triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO) inhibitors, superoxide scavengers and screening of their toxicological profile. Among all the synthesized compounds, B1 exhibited better inhibitory activity against bovine xanthine oxidase (bXO) than allopurinol (IC50 =1.56 μM and IC50 =6.99 μM, respectively). As superoxide scavengers, B1, B2 and B13 exhibited a better effect than allopurinol (97.3 %, 82.1 %, 87.4 % and 69.4 ...
Source: ChemMedChem - August 29, 2023 Category: Chemistry Authors: Marcela A Lopez-Sanchez Mar ía Del Carmen Garcia-Rodriguez Rodrigo Aguayo-Ortiz Estefani Hernandez-Cruz Diego I Figueroa-Figueroa Francisco Hernandez-Luis Source Type: research
In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents
CONCLUSION: In silico and in vitro results confirmed the good binding and inhibitory activity of some phenolic acids to the modeled target proteins. Among all the studied natural phenolic acids, chlorogenic acid, digallic acid, and rosmarinic acid appeared to be the most potential leads for future chemical alteration. This study can provide significant speculative guidance for the design and development of potent DHFR inhibitors in the future by using these compounds as leads.PMID:37641992 | DOI:10.2174/1389203724666230825142558
Source: Current Protein and Peptide Science - August 29, 2023 Category: Biochemistry Authors: Renu Sehrawat Priyanka Rathee Pooja Rathee Sarita Khatkar Esra Kupelli Akkol Anurag Khatkar Source Type: research
Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential
ChemMedChem. 2023 Aug 29:e202300184. doi: 10.1002/cmdc.202300184. Online ahead of print.ABSTRACTIn this work, a new set of quinazolin-2,4,6-triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO) inhibitors, superoxide scavengers and screening of their toxicological profile. Among all the synthesized compounds, B1 exhibited better inhibitory activity against bovine xanthine oxidase (bXO) than allopurinol (IC50 =1.56 μM and IC50 =6.99 μM, respectively). As superoxide scavengers, B1, B2 and B13 exhibited a better effect than allopurinol (97.3 %, 82.1 %, 87.4 % and 69.4 ...
Source: Cancer Control - August 29, 2023 Category: Cancer & Oncology Authors: Marcela A Lopez-Sanchez Mar ía Del Carmen Garcia-Rodriguez Rodrigo Aguayo-Ortiz Estefani Hernandez-Cruz Diego I Figueroa-Figueroa Francisco Hernandez-Luis Source Type: research
In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents
CONCLUSION: In silico and in vitro results confirmed the good binding and inhibitory activity of some phenolic acids to the modeled target proteins. Among all the studied natural phenolic acids, chlorogenic acid, digallic acid, and rosmarinic acid appeared to be the most potential leads for future chemical alteration. This study can provide significant speculative guidance for the design and development of potent DHFR inhibitors in the future by using these compounds as leads.PMID:37641992 | DOI:10.2174/1389203724666230825142558
Source: Current Protein and Peptide Science - August 29, 2023 Category: Biochemistry Authors: Renu Sehrawat Priyanka Rathee Pooja Rathee Sarita Khatkar Esra Kupelli Akkol Anurag Khatkar Source Type: research
Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis
J Nanobiotechnology. 2023 Aug 29;21(1):307. doi: 10.1186/s12951-023-02040-9.ABSTRACTA disorder of cholesterol homeostasis is one of the main initiating factors in the progression of atherosclerosis (AS). Metabolism and removal of excess cholesterol facilitates the prevention of foam cell formation. However, the failure of treatment with drugs (e.g. methotrexate, MTX) to effectively regulate progression of disease may be related to the limited drug bioavailability and rapid clearance by immune system. Thus, based on the inflammatory lesion "recruitment" properties of macrophages, MTX nanoparticles (MTX NPs) camouflaged with...
Source: Atherosclerosis - August 29, 2023 Category: Cardiology Authors: Li Zhu Hongjiao Li Jiyu Li Yuan Zhong Shuai Wu Meng Yan Sheng Ni Kun Zhang Guixue Wang Kai Qu Deqin Yang Xian Qin Wei Wu Source Type: research
Synthesis of Quinazolin-2,4,6-triamine Derivatives as Non-purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential
ChemMedChem. 2023 Aug 29:e202300184. doi: 10.1002/cmdc.202300184. Online ahead of print.ABSTRACTIn this work, a new set of quinazolin-2,4,6-triamine derivatives were synthesized to explore their potential biological activity as xanthine oxidase (XO) inhibitors, superoxide scavengers and screening of their toxicological profile. Among all the synthesized compounds, B1 exhibited better inhibitory activity against bovine xanthine oxidase (bXO) than allopurinol (IC50 =1.56 μM and IC50 =6.99 μM, respectively). As superoxide scavengers, B1, B2 and B13 exhibited a better effect than allopurinol (97.3 %, 82.1 %, 87.4 % and 69.4 ...
Source: ChemMedChem - August 29, 2023 Category: Chemistry Authors: Marcela A Lopez-Sanchez Mar ía Del Carmen Garcia-Rodriguez Rodrigo Aguayo-Ortiz Estefani Hernandez-Cruz Diego I Figueroa-Figueroa Francisco Hernandez-Luis Source Type: research
