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Drug: Methotrexate
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Total 5114 results found since Jan 2013.
Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation
In conclusion, we propose the study of the immunological signaling pathways in experimental humanized RA mice.PMID:37330038 | DOI:10.1016/j.drudis.2023.103671
Source: Drug Discovery Today - June 17, 2023 Category: Drugs & Pharmacology Authors: Sushmita Negi Nikunj Tandel Prakriti Sharma Rajinder Kumar Rajeev K Tyagi Source Type: research
Efficacy analysis of single-agent carboplatin AUC4 2-weekly as second-line therapy for methotrexate-resistant (MTX-R) low risk gestational trophoblastic neoplasia (GTN)
CONCLUSION: Carboplatin is not sufficiently active in the second-line treatment of low-risk MTX-resistant GTN. New strategies are required to increase hCG CR and spare more toxic CC regimens.PMID:37327541 | DOI:10.1016/j.ygyno.2023.05.072
Source: Gynecologic Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Matthew C Winter John A Tidy Kam Singh Naveed Sarwar Xianne Aguiar Michael J Seckl Source Type: research
Cigarette smoking is associated with decreased long-term treatment cessation of mycophenolate mofetil and methotrexate in cutaneous lupus erythematosus
Lupus. 2023 Jun 16:9612033231183500. doi: 10.1177/09612033231183500. Online ahead of print.NO ABSTRACTPMID:37328162 | DOI:10.1177/09612033231183500
Source: Lupus - June 16, 2023 Category: Rheumatology Authors: Henry W Chen Grant Sprow Rui Feng Victoria P Werth Benjamin F Chong Source Type: research
Psoriasis/Psoriatic Arthritis Patients' Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations
Acta Derm Venereol. 2023 Jun 15;103:adv6505. doi: 10.2340/actadv.v103.6505.ABSTRACTLimited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with psoriasis/psoriatic arthritis from 2012 to 2018 in Stockholm, Sweden. In addition, laboratory monitoring before initiation of treatment and at recommended intervals was quantified for patients prescribed methotrexate or biologics. A total of 51,639 individuals were included, with 39% initiating treatment wit...
Source: Acta Derm Venereol A... - June 15, 2023 Category: Dermatology Authors: Åsa Krantz Juan Jesus Carrero Yuanhang Yang Lovisa Schalin Josefin Lysell Faizan Mazhar Source Type: research
A Phase II Study of Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastasis from Solid Tumors
CONCLUSION: Concurrent IFRT and intrathecal MTX or Ara-C was proved to be a feasible treatment option with an acceptable safety profile for LM from a common tumor entity.PMID:37315582 | DOI:10.1016/j.radonc.2023.109740
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 14, 2023 Category: Radiology Authors: Zhenyu Pan Kunzhi Chen Hua He Tongchao Jiang Yuanyuan Song Xiaochuan Pang Xiaojun Ye Min Wang Tao Zhou Lihua Dong Guozi Yang Source Type: research
Methotrexate Polyglutamates Exposure - Response Modeling in a Large Cohort of Rheumatoid Arthritis Patients starting Methotrexate
Clin Pharmacol Ther. 2023 Jun 14. doi: 10.1002/cpt.2974. Online ahead of print.ABSTRACTMethotrexate polyglutamates (MTX-PG) concentrations in red blood cells (RBC) have been suggested as a biomarker of response in rheumatoid arthritis (RA) patients receiving low-dose MTX therapy. We investigated the association and inter-patient variability between RBC-MTX-PG3-5 -exposure and response in RA patients starting MTX. Data of three prospective cohorts were available. The relationship between exposure and Disease Activity Score (DAS28) was analysed using a population pharmacokinetic-pharmacodynamic (PKPD) model. Relevant covaria...
Source: Clinical Pharmacology and Therapeutics - June 14, 2023 Category: Drugs & Pharmacology Authors: Renske C F Hebing Imke H Bartelink Helen Gosselt Sandra G Heil Mauritis C F J de Rotte Pascal H P de Jong Mike T Nurmohamed Robert de Jonge Ron A A Math ôt Source Type: research
