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Drug: Methotrexate
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Total 5114 results found since Jan 2013.
High-Dose Methotrexate: Nursing Considerations for Administration and Supportive Care
This article provides an overview of HDMTX treatment and nursing considerations, including toxicities, components of supportive care management, and strategies to manage administration and delayed elimination of MTX.METHODS: A review of published literature and guidelines was performed to evaluate nursing considerations for patients receiving HDMTX.FINDINGS: Using existing and novel tools, nurses can closely monitor patients and provide supportive care to mitigate HDMTX toxicity. Early identification of delayed MTX elimination and subsequent treatment with glucarpidase, if appropriate, has been associated with shorter leng...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Breanne Roche Patricia A Clarke Danielle Ford Shannon Collins Shaver Joanna Thompson Source Type: research
Endothelial Progenitor Cells in Autoimmune Disorders
The objective of this review was to describe EPCs, their properties and their involvement in several autoimmune diseases.PMID:37676423 | DOI:10.1007/s12015-023-10617-y
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Guillaume Feugray S ébastien Miranda V éronique Le Cam Duchez J érémy Bellien Paul Billoir Source Type: research
High-Dose Methotrexate: Nursing Considerations for Administration and Supportive Care
This article provides an overview of HDMTX treatment and nursing considerations, including toxicities, components of supportive care management, and strategies to manage administration and delayed elimination of MTX.METHODS: A review of published literature and guidelines was performed to evaluate nursing considerations for patients receiving HDMTX.FINDINGS: Using existing and novel tools, nurses can closely monitor patients and provide supportive care to mitigate HDMTX toxicity. Early identification of delayed MTX elimination and subsequent treatment with glucarpidase, if appropriate, has been associated with shorter leng...
Source: Clinical Journal of Oncology Nursing - September 7, 2023 Category: Nursing Authors: Breanne Roche Patricia A Clarke Danielle Ford Shannon Collins Shaver Joanna Thompson Source Type: research
The potential protectivity of honey and olive oil in methotrexate induced renal damage in rats
This study aimed to assess the possible protective effect of H and OO intake either singly or together against the biochemical and structural Methotrexate-induced nephrotoxicity in rats. The study was conducted on 56 adult albino rats, they were divided into seven groups (n = 8): group 1 received only distelled water (negative control), group 2 received H (1.2g/kg/day), group 3 received OO (1.25ml/kg/day), group 4 received a single intraperitoneal injection of MTX (20mg/kg), group 5 received MTX and H, group 6 received MTX and OO, group 7 received MTX, H and OO together. At the end of the experiment (2 weeks), all rats wer...
Source: Toxicon - September 6, 2023 Category: Toxicology Authors: Gamal S Abd El-Aziz Hani A Alturkistani Rasha A Alshali Mervat M Halawani Raid M Hamdy Waheeb S Aggad Nezar J Kamal Emad A Hindi Source Type: research
Retrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in TNF signaling
CONCLUSIONS: Our study implicates the genetic regulation of cytokine responses in predicting clinical drug response and supports the association between pharmacogenetic loci and anti-TNF response, as shown here for KLK7.PMID:37672660 | DOI:10.1093/bjd/ljad332
Source: The British Journal of Dermatology - September 6, 2023 Category: Dermatology Authors: Haihan Zhang Matthew T Patrick Trilokraj Tejasvi Mrinal K Sarkar Rachael Wasikowski Philip E Stuart Qinmengge Li Xianying Xing John J Voorhees Nicole L Ward Kevin He Xiang Zhou Johann E Gudjonsson Rajan P Nair James T Elder Lam C Tsoi Source Type: research
The potential protectivity of honey and olive oil in methotrexate induced renal damage in rats
This study aimed to assess the possible protective effect of H and OO intake either singly or together against the biochemical and structural Methotrexate-induced nephrotoxicity in rats. The study was conducted on 56 adult albino rats, they were divided into seven groups (n = 8): group 1 received only distelled water (negative control), group 2 received H (1.2g/kg/day), group 3 received OO (1.25ml/kg/day), group 4 received a single intraperitoneal injection of MTX (20mg/kg), group 5 received MTX and H, group 6 received MTX and OO, group 7 received MTX, H and OO together. At the end of the experiment (2 weeks), all rats wer...
Source: Toxicon - September 6, 2023 Category: Toxicology Authors: Gamal S Abd El-Aziz Hani A Alturkistani Rasha A Alshali Mervat M Halawani Raid M Hamdy Waheeb S Aggad Nezar J Kamal Emad A Hindi Source Type: research
Retrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in TNF signaling
CONCLUSIONS: Our study implicates the genetic regulation of cytokine responses in predicting clinical drug response and supports the association between pharmacogenetic loci and anti-TNF response, as shown here for KLK7.PMID:37672660 | DOI:10.1093/bjd/ljad332
Source: The British Journal of Dermatology - September 6, 2023 Category: Dermatology Authors: Haihan Zhang Matthew T Patrick Trilokraj Tejasvi Mrinal K Sarkar Rachael Wasikowski Philip E Stuart Qinmengge Li Xianying Xing John J Voorhees Nicole L Ward Kevin He Xiang Zhou Johann E Gudjonsson Rajan P Nair James T Elder Lam C Tsoi Source Type: research
