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XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Pharmacists' interventions on clinical asthma outcomes: a systematic review
The objective of this systematic review was to evaluate the impact of pharmacists' interventions on clinical asthma outcomes on adult patients and to identify the outcome indicators used. PubMed, Scopus, Web of Science and Scielo were searched. Studies addressing pharmacists' interventions on adult asthma patients reporting clinical asthma outcomes were incorporated. 11 clinical outcomes were identified in 21 studies. 10 studies measured the impact of the intervention on asthma control. Randomised controlled trials (RCT) and non-RCTs found positive results in percentages of controlled patients and Asthma Control Questionna...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Garcia-Cardenas, V., Armour, C., Benrimoj, S. I., Martinez-Martinez, F., Rotta, I., Fernandez-Llimos, F. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Interleukin‐9 and interleukin‐17C in chronic rhinosinusitis
ConclusionInflammatory cell expression of IL‐9 and IL‐17C were increased in CRS, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of CRSwNP as well as atopy and may serve as therapeutic targets for disease management.
Source: International Forum of Allergy and Rhinology - March 17, 2016 Category: Allergy & Immunology Authors: Clara M. Olcott, Joseph K. Han, Tina D. Cunningham, Christine B. Franzese Tags: ORIGINAL ARTICLE Source Type: research

Interleukin ‐9 and interleukin‐17C in chronic rhinosinusitis
ConclusionInflammatory cell expression of IL‐9 and IL‐17C were increased in CRS, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of CRSwNP as well as atopy and may serve as therapeutic targets for disease management.
Source: International Forum of Allergy and Rhinology - March 16, 2016 Category: Allergy & Immunology Authors: Clara M. Olcott, Joseph K. Han, Tina D. Cunningham, Christine B. Franzese Tags: ORIGINAL ARTICLE Source Type: research

Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study.
CONCLUSION: EESS for patients with CRSwNP and with asthma may help to improve the subjective olfaction and endoscopic appearance. PMID: 26980396 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2016 Category: ENT & OMF Authors: Chen FH, Deng J, Hong HY, Xu R, Guo JB, Hou WJ, Sun YQ, Lai YY, Li HB, Shi JB Tags: Am J Rhinol Allergy Source Type: research

Inhaled-corticosteroids, body weight and height in children with asthma
Conclusion: Long-term ICS therapy is not that determining for height and weight status in asthma patients.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Petrova, G., Papochieva, V., Lazova, S., Miteva, D., Temelkova, K., Perenovska, P. Tags: 7.2 Paediatric Asthma and Allergy Source Type: research

Airway inflammation and hyperresponsiveness study in skier children determined by induced sputum and mannitol test
Conclusions: We have not found differences in hyperresponsiveness nor inflammation in skier children. Sputum cell viability is higher at 2000m.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Vizmanos-Lamotte, G., Canturri Gispert, E., Alvarez Castillo, L., Ribo Campa, C., Henket, M., Cruz, M. J., Louis, R., Moreno-Galdo, A. Tags: 7.2 Paediatric Asthma and Allergy Source Type: research

Relation of ghrelin, obestatin levels and ghrelin/obestatin ratio with asthma
Conclusions: Ghrelin, obestatin levels and ghrelin/obestatin ratio were similar to the control group in stable asthmatic patients in this study. Although they were similar in terms of body mass index and waist circumference length; homa score were significantly higher in patients with asthma.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kizilirmak, D., Bozkurt, B. Tags: 5.3 Allergy and Immunology Source Type: research

Relation of hemogram parameters with asthma
Conclusions: Elevation of RDW was shown on diseases resulting right ventricle failure. RDW was significantly higher in patients with asthma according to control group in our study.Increased neutrophil-lymphocyte ratio was shown on systemic inflammatory diseases. In our study, neutrophil-lymphocyte ratio was significantly higher in patients with stable asthma. Statistically significant correlation between asthma control and neutrophil-lymphocyte ratio was not detected.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Bozkurt, B., Kizilirmak, D. Tags: 5.3 Allergy and Immunology Source Type: research

Sputum eosinophilia in severe allergic asthma is not a reliable marker of omalizumab treatment
Conclusions: ACQ and AQLQ are better markers than sputum eosinophilia in the evaluation of clinical improvement after 16 weeks of omalizumab treatment.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Hermanowicz-Salamon, J., Nejman-Gryz, P., Rubinsztajn, R., Paplinska-Goryca, M., Chazan, R. Tags: 5.3 Allergy and Immunology Source Type: research

LATE-BREAKING ABSTRACT: The study of fibulin-1 as a novel biomarker in bronchial asthma and its association to disease severity
Conclusion: This may highlight the potential role of fibulin-1 in airway wall remodeling.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: El Giziry, D., Zakaria, N., Kassem, A., Abdellatif, M. Tags: 5.3 Allergy and Immunology Source Type: research

Quantitative sinonasal symptom assessment in an unselected pediatric population with cystic fibrosis.
CONCLUSIONS: The SN-5 tool provides a quick, safe, and reliable qualitative metric for monitoring sinonasal symptoms in young children with CF. PMID: 26358346 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - September 1, 2015 Category: ENT & OMF Authors: Wentzel JL, Virella-Lowell I, Schlosser RJ, Soler ZM Tags: Am J Rhinol Allergy Source Type: research

Predicting asthma morbidity in children using proposed markers of Th2‐type inflammation
ConclusionsAssessment of both local and systemic Th2‐mediated inflammation by analysis of easily attainable biomarkers such as exhaled NO and blood eosinophils has a high predictive value for the identification of children with the highest asthma morbidity. Adjusting FeNO values according to the individual child′s height increases the clinical usefulness of this biomarker.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - August 12, 2015 Category: Allergy & Immunology Authors: Jon R Konradsen, Elizabeth Skantz, Björn Nordlund, Marika Lidegran, Anna James, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Sven‐Erik Dahlén, Kjell Alving, Gunilla Hedlin Tags: Original Article Source Type: research

Sputum high mobility group box-1 in asthmatic children: a noninvasive sensitive biomarker reflecting disease status.
CONCLUSION: The present study provides evidence that sputum HMGB1 is a sensitive biomarker of allergic asthma in children because it was increased and correlated directly with asthma severity and inversely with lung function indices. PMID: 26250770 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Cuppari C, Manti S, Chirico V, Caruso R, Salpietro V, Giacchi V, Laganà F, Arrigo T, Salpietro C, Leonardi S Tags: Ann Allergy Asthma Immunol Source Type: research

Longitudinal study of the expression of FcεRI and IgE on basophils and dendritic cells in association with basophil function in two patients with severe allergic asthma treated with Omalizumab.
We report two mite-allergic severe asthmatic patients successfully treated with omalizumab for one year. Clinically, patients improved gradually, with no further need for systemic steroids or emergency department visits during that treatment period, and with Asthma Control Test (ACT) scores showing controlled disease, although pulmonary function didn't show any significant improvement. Immunologically, we observed marked down-regulation of surface IgE and FcεRI on basophils, plasmacytoid and myeloid dendritic cells, as well as a reduction of basophil activation after specific allergen stimulation. These effects were clear...
Source: European Annals of Allergy and Clinical Immunology - June 4, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research