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Specialty: Infectious Diseases

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Total 742 results found since Jan 2013.

Flu Vaccine Allergy May Be Attributed to Gelatin, Not EggFlu Vaccine Allergy May Be Attributed to Gelatin, Not Egg
An allergy to egg is no longer contraindicated for influenza vaccination, but gelatin allergy, though rare, can cause anaphylaxis. Medscape Medical News
Source: Medscape Infectious Diseases Headlines - November 21, 2013 Category: Infectious Diseases Tags: Allergy & Clinical Immunology News Source Type: news

Improving Clinical Outcomes in Patients With Methicillin-Sensitive Staphylococcus aureus Bacteremia and Reported Penicillin Allergy
Conclusions. Patients with MSSA bacteremia and a reported PCN allergy should have the allergy addressed for optimal treatment. Full allergy evaluation with skin testing seems to be preferred, although more data are needed.
Source: Clinical Infectious Diseases - August 10, 2015 Category: Infectious Diseases Authors: Blumenthal, K. G., Parker, R. A., Shenoy, E. S., Walensky, R. P. Tags: ARTICLES AND COMMENTARIES Source Type: research

Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study
Conclusions. Avoidance of preferred beta-lactam therapy in patients who report allergy is associated with an increased risk of adverse events. Development of inpatient programs aimed at accurately identifying beta-lactam allergies to safely promote beta-lactam administration among these patients is warranted.
Source: Clinical Infectious Diseases - September 11, 2016 Category: Infectious Diseases Authors: MacFadden, D. R., LaDelfa, A., Leen, J., Gold, W. L., Daneman, N., Weber, E., Al-Busaidi, I., Petrescu, D., Saltzman, I., Devlin, M., Andany, N., Leis, J. A. Tags: ARTICLES AND COMMENTARIES Source Type: research

The impact of penicillin allergy records on carbapenem prescribing: an observational retrospective cohort study: Meropenem prescribing associated with penicillin allergy records
This study measured the impact of penicillin allergy labels on meropenem prescribing.Rates of meropenem prescribing were compared between patients with a penicillin allergy record and patients without such a record. Potential confounders were also collected (age, sex, co-morbidity).Of the 21,272 patients with no penicillin allergy 225 (1.06%) were prescribed meropenem, whereas of the 3443 with penicillin allergy 240 (6.97%) were prescribed meropenem.Meropenem prescribing is associated with a patient’s penicillin allergy record. Given that many penicillin allergy records are incorrect, addressing spurious penicillin aller...
Source: Journal of Hospital Infection - December 7, 2018 Category: Infectious Diseases Source Type: research

Impact of penicillin allergy records on carbapenem prescribing: an observational retrospective cohort study
This study measured the impact of penicillin allergy labels on meropenem prescribing. Rates of meropenem prescribing were compared between patients with a penicillin allergy record and patients without such a record. Potential confounders were also collected (i.e. age, sex and co-morbidities). Of the 21,272 patients with no penicillin allergy, 225 (1.06%) were prescribed meropenem, whereas of the 3443 patients with penicillin allergy, 240 (6.97%) were prescribed meropenem. Meropenem prescribing is associated with a patient's penicillin allergy record. Given that many penicillin allergy records are incorrect, addressing spu...
Source: Journal of Hospital Infection - January 11, 2019 Category: Infectious Diseases Source Type: research

Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy.
Authors: Vyles D, Macy E Abstract INTRODUCTION: About 8% of the United States population carries an unconfirmed penicillin "allergy" in their medical record. Many physicians needlessly avoid other beta-lactam use in individuals with unconfirmed penicillin allergies. There is a significantly increased risk of developing serious antibiotic-resistant infections, and increased morbidity and mortality in those who report penicillin allergy. Areas covered: Within this study we reviewed the relevant literature on self-reported beta-lactam allergy. We discuss how the myth of serious allergy to penicillin developed and then...
Source: Expert Review of Anti-Infective Therapy - May 10, 2019 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Trends in Antimicrobial Allergies in Patients Seen in Infectious Disease Consultation During Selected Periods 2007–2016: Increases in Multidrug-Intolerant Individuals but Relative Stability in Antimicrobial Allergy Prevalence
Conclusions Overall allergy rates for several antimicrobials were high but stable over study period; nonantibiotic allergies rose. Multidisciplinary allergy documentation is crucial in accurate data collection. Antibiotic-allergic and multiple drug intolerant patients are a good focus for prospective allergy education and “delabeling” programs.
Source: Infectious Diseases in Clinical Practice - March 1, 2022 Category: Infectious Diseases Tags: Original Articles Source Type: research

Antimicrobial stewardship intervention: optimizing antibiotic treatment in hospitalized patients with reported antibiotic allergy
ConclusionThis antimicrobial stewardship intervention can be used to provide patients with reported antibiotic allergy labels with the preferred antibiotic treatment and to de-label them after uneventful re-exposure to the antibiotic agent.
Source: Journal of Hospital Infection - October 15, 2019 Category: Infectious Diseases Source Type: research

Evaluation of the Implementation of an Allergy Assessment Tool as an Antimicrobial Stewardship Initiative
Conclusions: Standardized, pharmacist-led allergy assessments allow for easier conversion to first-line β-lactam antibiotic therapy, indicating that formal allergy assessments may serve as an important antimicrobial stewardship tool.
Source: Infectious Diseases in Clinical Practice - November 1, 2016 Category: Infectious Diseases Tags: Original Articles Source Type: research

Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis Host-Associated Microbial Communities
In this study, we analyzed effects of gut and oral dysbiosis on development of food allergy. A murine model of food allergy was established via ovalbumin (OVA) injection in BALB/c mice. Viable fecal bacteria were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS). il33 expression in colon-26 mouse colon cells stimulated by isolated fecal bacteria was quantified by real-time PCR. Intestinal T cells from the mice were analyzed by flow cytometry. Salivary IgA levels were quantified by enzyme-linked immunosorbent assay (ELISA), and IgA-bound oral bacteria were det...
Source: Infection and Immunity - December 16, 2019 Category: Infectious Diseases Authors: Matsui, S., Kataoka, H., Tanaka, J.-I., Kikuchi, M., Fukamachi, H., Morisaki, H., Matsushima, H., Mishima, K., Hironaka, S., Takaki, T., Okahashi, N., Maruoka, Y., Kuwata, H. Tags: Host-Associated Microbial Communities Source Type: research

Contribution of Penicillin Allergy Labels to Second-Line Broad-Spectrum Antibiotic Prescribing for Pediatric Respiratory Tract Infections
ConclusionIn a large population of pediatric outpatient encounters for acute respiratory tract infections, patients labeled with a penicillin allergy accounted for nearly half of second-line antibiotics, which are often broader spectrum. Efforts to de-label children with penicillin allergies have the potential to reduce broader-spectrum antibiotic use.
Source: Infectious Diseases and Therapy - July 12, 2020 Category: Infectious Diseases Source Type: research

Is there a higher prevalence of methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) colonization in patients with antibiotic allergy labels?
ConclusionsAn antibiotic allergy label was associated with significantly higher rates of MRSA colonization but no statistical difference with VRE colonization.
Source: American Journal of Infection Control - November 15, 2019 Category: Infectious Diseases Source Type: research

The democratisation of de-labelling: a review of direct oral challenge in adults with low-risk penicillin allergy.
Authors: Rose MT, Slavin M, Trubiano J Abstract INTRODUCTION: Penicillin antibiotic allergy labels (AALs) are common and lead to significant negative health and health system outcomes. Direct oral challenge offers a rapid and cost-effective way of removing inaccurate AALs and improving outcomes. AREAS COVERED: A narrative review (Medline, May 2020) of direct oral challenge in low-risk penicillin allergy in adults is described and the evidence for the safety and efficacy of this approach in inpatients, outpatients and special patient groups is presented. EXPERT OPINION: Whilst the current literature demonstr...
Source: Expert Review of Anti-Infective Therapy - July 15, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Beta-lactam Allergy Review: Implications for Antimicrobial Stewardship Programs
AbstractPurpose of reviewBeta-lactam allergies, and specifically penicillin allergies, result in receipt of therapy that is not considered first line in many instances. Being labeled as allergic many times comes via subjective history from the patient. Carrying this label can cause a patient to receive broad-spectrum therapy with increased side effects and resistance. Antimicrobial stewardship programs can play a role in allergy evaluation and intervention based on resources. This review provides an update on beta-lactam allergies and emphasizes incorporation of evaluating these patients as a core tenant of antimicrobial s...
Source: Current Treatment Options in Infectious Diseases - April 30, 2019 Category: Infectious Diseases Source Type: research

Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series
This study confirms the presence of this new entity in French Guiana and is the largest reported in Latin America. Our results do not clearly allow us to state that tick bites are the cause of this allergy, but all patients reported being exposed regularly to these arthropods.PMID:34544046 | DOI:10.4269/ajtmh.20-1630
Source: Am J Trop Med Hyg - September 20, 2021 Category: Infectious Diseases Authors: Lo ïc Epelboin Florent Roche Maryvonne Dueymes Genevi ève Guillot Olivier Duron Mathieu Nacher F élix Djossou Ang èle Soria Source Type: research