Candida auris outbreak on a vascular ward – the unexpected arrival of an anticipated pathogen
Publication date: Available online 17 June 2019Source: Journal of Hospital InfectionAuthor(s): C. O'Connor, T. Bicanic, J. Dave, T.J. Evans, P. Moxey, U. Adamu, D. Shakespeare, M. Cotter (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 18, 2019 Category: Infectious Diseases Source Type: research

Two year analysis of Clostridium difficile ribotypes associated with increased severity
ConclusionsA wide range of C. difficile ribotypes were responsible for C. difficile infection presentations. Although C. difficile-associated mortality has reduced in recent years, expansion of lineages associated with increased severity could herald increases in future mortality. Enhanced surveillance for emerging lineages such as RT220 that are associated with more severe disease is required, with genomic approaches to dissect pathogenicity. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 18, 2019 Category: Infectious Diseases Source Type: research

Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence
Publication date: Available online 18 June 2019Source: Journal of Hospital InfectionAuthor(s): Bryn Short, Jason Brown, Christopher Delaney, Leighann Sherry, Craig Williams, Gordon Ramage, Ryan KeanAbstractSurfaces within healthcare play a key role in the transmission of drug-resistant pathogens. Candida auris is an emerging multi-drug resistant yeast which has the ability to survive for prolonged periods on environmental surfaces. Here we show that the ability to form cellular aggregates increases survival after 14 days, which coincides with the upregulation of biofilm-associated genes. Additionally, the aggregating strai...
Source: Journal of Hospital Infection - June 18, 2019 Category: Infectious Diseases Source Type: research

Tracking Staphylococcus aureus in the intensive care unit using whole-genome sequencing
This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one 10-bed intensive care unit (ICU).MethodsSelected hand-touch surfaces, staff hands and air were screened systematically 10 times during 10 months, with patients screened throughout the study. S. aureus isolates were subjected to spa typing and epidemiological analyses, followed by whole-genome sequencing to provide single nucleotide polymorphism (SNP) data.ResultsMultiple transmission pathways between patients and reservoirs were investigated. There were 34 transmission events, of which 29 were highly related (
Source: Journal of Hospital Infection - June 17, 2019 Category: Infectious Diseases Source Type: research

Effects of prophylactic use of taurolidine-citrate lock on the number of catheter-related infections in children under 2 years of age undergoing surgery
Publication date: Available online 2 May 2019Source: Journal of Hospital InfectionAuthor(s): M. Łyszkowska, G. Kowalewski, M. Szymczak, D. Polnik, A. Mikołajczyk, P. KalicińskiSummaryCentral venous access poses a risk for the development of catheter-related infections (CRIs). The aim of this study was to evaluate prophylactic use of taurolidine-citrate (T-C) solution on the number of CRIs. Ninety-seven catheters, used in 86 children, were divided at random into two groups: Group T(-) (N=49) underwent standard aseptic procedures, and Group T(+) (N=48) received additional filling of the lines with T-C solution during inte...
Source: Journal of Hospital Infection - June 16, 2019 Category: Infectious Diseases Source Type: research

Managing seasonal influenza in hospitalized patients – without an influenza point-of-care test
Publication date: Available online 21 May 2019Source: Journal of Hospital InfectionAuthor(s): G. Hills, M. Kennedy, O. Ahmed, J.W. Tang (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 16, 2019 Category: Infectious Diseases Source Type: research

Molecular epidemiology study of a nosocomial Moraxella catarrhalis outbreak in a neurological rehabilitation unit
ConclusionThe first M. catarrhalis outbreak involving nine patients of a neurological and trauma rehabilitation centre was reported. Potential transmission pathways were discussed. Comprehensive outbreak analyses insinuated the extension of routine laboratory storage time for defined species. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 14, 2019 Category: Infectious Diseases Source Type: research

Interlaboratory reproducibility of a test method following four-field test methodology to evaluate the susceptibility of Clostridium difficile spores
Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Bärbel Christiansen, Heike Martiny, Lutz Vossebein, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter Kampf, Martin ExnerSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to determine the sporicidal activity in suspension and has been approved as a European standard. In addition, a spo...
Source: Journal of Hospital Infection - June 14, 2019 Category: Infectious Diseases Source Type: research

Interlaboratory reproducibility of a test method following 4-field test methodology to evaluate the susceptibility of Clostridium difficile spores
Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Katrin Steinhauer, Bärbel Christiansen, Heike Martiny, Bernhard Meyer, Christiane Ostermeyer, Hans-Joachim Rödger, Lutz Vossebein, Lars Paßvogel, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Heike Vogelsang, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter KampfSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to dete...
Source: Journal of Hospital Infection - June 13, 2019 Category: Infectious Diseases Source Type: research

Analysis of Acinetobacter baumannii survival in liquid media and on solid matrices as well as effect of disinfectants
ConclusionThe ability to persist for long periods on different surfaces, mimicking those usually found in hospitals, along with A. baumannii's capacity to survive after a disinfection process may account for the recurrent outbreaks in intensive care units. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 9, 2019 Category: Infectious Diseases Source Type: research

Dissemination of NDM-1 carbapenemase-producer Providencia stuartii strains in Romanian hospitals: a multicentre study
Publication date: Available online 27 April 2019Source: Journal of Hospital InfectionAuthor(s): S. Molnár, M.M.M. Flonta, A. Almaş, M. Buzea, M. Licker, M. Rus, A. Földes, E. SzékelySummarySeveral Romanian hospitals have noted increasing isolation of Providencia stuartii strains in recent years, with an alarming rate of carbapenem resistance. In order to provide molecular epidemiological data regarding their dissemination, 77 P. stuartii strains collected from five hospitals located in different regions of Romania were analysed. All strains harboured IncA/C plasmid, and 67 carried the blaNDM-1 gene...
Source: Journal of Hospital Infection - June 9, 2019 Category: Infectious Diseases Source Type: research

Evaluation of surgical site infection antibiotic prophylaxis among patients receiving antibiotics for active infection
Publication date: Available online 8 June 2019Source: Journal of Hospital InfectionAuthor(s): Cynthia T. Nguyen, Claire M. Reuter, Tracy Hudson, Julius Li (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 9, 2019 Category: Infectious Diseases Source Type: research

Community prevalence of carbapenemase-producing organisms in East London
ConclusionTo date, there have been no studies investigating the prevalence of CPOs in the UK community. Given the high-risk patient population served by Barts Health NHS Trust, it is reassuring that the prevalence observed here was low. However, it should be highlighted that travel to countries not previously categorized as high risk may also pose a threat. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 8, 2019 Category: Infectious Diseases Source Type: research

Residual effect of community antimicrobial exposure on risk of hospital onset healthcare associated Clostridioides difficile infection: a case-control study using national linked data
ConclusionsCommunity antimicrobial exposure is an independent risk factor for HA-CDI and should be considered as part of the risk assessment of patients developing diarrhoea in hospital. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 5, 2019 Category: Infectious Diseases Source Type: research

Variations In Antibiotic Use Across India – Multicentre Study Through Global Point Prevalence Survey
Publication date: Available online 3 June 2019Source: Journal of Hospital InfectionAuthor(s): Sanjeev K. Singh, Sharmila Sengupta, Remya Antony, Sanjay Bhattacharya, Chiranjay Mukhopadhyay, V. Ramasubramanian, Anita Sharma, Suneeta Sahu, .Suhas Nirkhiwale, Dr.Sweta Gupta, Anusha Rohit, Sunil Sharma, Vaidehi Raghavan, Purabi Barman, Smita Sood, Dhruv Mamtora, Sukhanya Rengaswamy, Anita Arora, Herman Goossens, Ann VersportenSummaryThe aim of the study was to assess antimicrobial prescribing patterns, and variation in practice, in India. A point prevalence survey (PPS) was conducted in Oct-Dec 2017 in 16 tertiary care hospita...
Source: Journal of Hospital Infection - June 4, 2019 Category: Infectious Diseases Source Type: research

Norovirus Recovery from Floors and Air after Different Decontamination Protocols
Publication date: Available online 2 June 2019Source: Journal of Hospital InfectionAuthor(s): Caroline L. Ciofi-Silva, Camila Q.M. Bruna, Rita D.C. Carmona, Alda G.C.D. Almeida, Fabiana C.P. dos Santos, Natalia M. Inada, Vanderlei S. Bagnato, Kazuko U. GrazianoSummaryBackgroundThe dispersal of airborne norovirus (NoV) particles from the floor after faecal or vomit contamination is a challenge for infection control, as this pathogen is infectious at low doses. Therefore, it is imperative to establish a safe protocol for floor decontamination.AimTo assess the presence of residual NoV-GII particles on floor and airborne parti...
Source: Journal of Hospital Infection - June 3, 2019 Category: Infectious Diseases Source Type: research

Letter to the Editor
Publication date: Available online 29 May 2019Source: Journal of Hospital InfectionAuthor(s): Bente Olesen, Inge Ulriksen, Mikkel Kreiner-Moeller, Dorthe Tomsen, Anne-Marie Thye (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 31, 2019 Category: Infectious Diseases Source Type: research

Working Party Guidance on the control of multi-resistant Acinetobacter outbreaks
Publication date: Available online 29 May 2019Source: Journal of Hospital InfectionAuthor(s): Barry Cookson (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 29, 2019 Category: Infectious Diseases Source Type: research

Continuous Monitoring of Aerial Bioburden within Intensive Care Isolation Rooms and Identification of ‘High Risk’ Activities
ConclusionPeaks in airborne contamination showed a direct relation to an increase in activity levels. This study provides first clear evidence of the extent of variability in microbial airborne levels over 24-hour periods in ICU isolation rooms and directly correlates microbial load to ward activity. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 29, 2019 Category: Infectious Diseases Source Type: research

Mitigation of microbial contamination from waste water and aerosolization by sink design
ConclusionsLimiting microbial contamination is critical for the control of nosocomial infections of in-room sinks, which provide a major source of contamination. Our experimental sink studies document that regular ozonated water rinsing of the sink surface, decontamination of p-trap water, and UV decontamination of surfaces limits microbial aerosolization and surface contamination, with potential to decrease patient exposure and reduce hospital acquired infections. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 29, 2019 Category: Infectious Diseases Source Type: research

A survey to quantify wet loads after steam sterilisation processes in healthcare facilities
Publication date: Available online 24 May 2019Source: Journal of Hospital InfectionAuthor(s): Josephus P.C.M. van Doornmalen, Francesco Tessarolo, Nicole Lapanaitis, Krist Henrotin, Agostino Inglese, Harry Oussoren, Rafael Queiroz de SouzaSummaryWet loads after steam sterilisation of medical devices in health care facilities are unacceptable. However, little is known about their frequency in daily practice. Via four national sterilisation associations, in Australia (VIC SRACA), Belgium (VSZ), Italy (AIOS), and the Netherlands (VDSMH), an online survey was distributed. 78% of 125 hospital sterilisation facilities recognised...
Source: Journal of Hospital Infection - May 25, 2019 Category: Infectious Diseases Source Type: research

An Outbreak of MRSA colonisation in a Neonatal intensive care unit: use of a case control study to investigate and control it and lessons learned
We describe the investigation and management of an MRSA outbreak on a neonatal intensive care unit (NICU) and the lessons learnt.Study designOutbreak report and case-control study.Study setting and participants: The study was conducted in a 40-cot NICU in a tertiary referral hospital and included all infants colonised/infected with gentamicin-resistant MRSA.InterventionsStandard infection control measures including segregation of infants, barrier precautions, enhanced cleaning, assessment of staff practice including hand hygiene, and increased MRSA screening of infants were implemented. Continued MRSA acquisitions led to s...
Source: Journal of Hospital Infection - May 25, 2019 Category: Infectious Diseases Source Type: research

Escherichia coli bloodstream infection outcomes and preventability; a 6 month prospective observational study
ConclusionsE. coli BSI has an appreciable mortality, with little in the way of modifiable risk factors for mortality or prolonged hospital stay. Attention to urinary catheter use is likely to be the most useful way to reduce the incidence, but current UK reduction targets may be unachievable. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 23, 2019 Category: Infectious Diseases Source Type: research

Model to evaluate the impact of hospital-based interventions targeting false-positive blood cultures on economic and clinical outcomes
ConclusionCosts and clinical burdens associated with false-positive cultures are substantial and can be reduced by available interventions, including phlebotomists and use of ISDD. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand
This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Editorial Board
Publication date: June 2019Source: Journal of Hospital Infection, Volume 102, Issue 2Author(s): (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Whole genome sequencing of toxigenic Clostridium difficile in asymptomatic carriers: insights into possible role in transmission
ConclusionThis small study of asymptomatic carriage revealed a rectal asymptomatic carriage rate of 14.6% in patients nursed in ICBFs, and a high level of genetic similarity of these strains to those recovered from symptomatic patients. As such, asymptomatic carriers may be important for the transmission of symptomatic CDI, although it is acknowledged that this study was small, and many other factors govern whether C. difficile is carried asymptomatically or causes symptoms. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Effectiveness of behavioural interventions to reduce urinary tract infections and Escherichia coli bacteraemia for older adults across all care settings: a systematic review
ConclusionThe heterogeneity of studies means that one effective intervention cannot be recommended. We suggest that feedback should be considered because it facilitated reductions in UTI when used alone or in multi-faceted interventions including education, audit or catheter removal protocols. Multi-faceted education is likely to be effective. Catheter removal protocols, increased staffing, and patient education require further evaluation. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Managing seasonal influenza in hospitalised patients - without an influenza point-of-care test
Publication date: Available online 21 May 2019Source: Journal of Hospital InfectionAuthor(s): George Hills, Matthew Kennedy, Osama Ahmed, Julian W. Tang (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 22, 2019 Category: Infectious Diseases Source Type: research

Combining detergent/disinfectant with microfibre material provides a better control of microbial contaminants on surfaces than the use of water alone
Publication date: Available online 18 May 2019Source: Journal of Hospital InfectionAuthor(s): Robertson A, Barrell M, Maillard J-YSummaryThe use of microfibre cloths with either water, detergent or disinfectant is currently recommended for hospital cleaning. We explore the efficacy of a microfibre cloth with either water or detergent/disinfectant or sporicidal products using the ASTM2967-15 standard against Staphylococcus aureus, Acinetobacter baumannii and spores Clostridium difficile spores. The use of detergent/disinfectant or sporicidal products had a significantly (ANOVA, p
Source: Journal of Hospital Infection - May 19, 2019 Category: Infectious Diseases Source Type: research

Evaluation of a Web-Based Tool for Labelling Potential Hospital Outbreaks, a Mixed Methods Study
ConclusionThe interactive web application was both usable and useful for infection control practitioners. Its implementation in routine practice could help professionals identify potential outbreaks while creating data to train automated detection algorithms. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 14, 2019 Category: Infectious Diseases Source Type: research

Prevalence of healthcare-associated infections and antimicrobial resistance in acute care hospitals in Kyiv, Ukraine
ConclusionsInfection control priorities in hospitals should include prevention of surgical site infections, pneumonia, bloodstream infections and urinary tract infections. These results may help to delineate the requirements for infection prevention and control in acute care hospitals. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 11, 2019 Category: Infectious Diseases Source Type: research

Should central venous catheters be rapidly removed to treat Staphylococcus aureus related-catheter bloodstream infection (CR-BSI) in neonates and children? An 8-year period (2010–2017) retrospective analysis in a French University Hospital
Publication date: Available online 4 April 2019Source: Journal of Hospital InfectionAuthor(s): L. Boussamet, E. Launay, E. Thomas, C. Gras Leguen, D. LepelletierSummaryCatheter-related bloodstream infection (CR-BSI) treatment is based on empiric antibiotherapy associated with or without catheter removal. The aim of this study was to compare the incidence of failures in neonates and children with Staphylococcus aureus CR-BSI with or without rapid catheter removal. Treatment failure was defined as the persistence of positive blood cultures, onset or aggravation of a local or systemic complication, or relapse. Fifty-four CR-B...
Source: Journal of Hospital Infection - May 11, 2019 Category: Infectious Diseases Source Type: research

The open-air factor and infection control
Publication date: Available online 9 April 2019Source: Journal of Hospital InfectionAuthor(s): R.A. Hobday (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 11, 2019 Category: Infectious Diseases Source Type: research

Nosocomial Infection by Human Bocavirus and Human Rhinovirus among Paediatric Patients with Respiratory Risks
ConclusionThe patients with respiratory risks easily develop respiratory symptoms and acquire severe symptoms of nosocomial infection by those viruses. In a paediatric ward, we should adopt not only standard precaution but also isolation management to the patients with respiratory symptoms, even if they have negative results in rapid tests. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 11, 2019 Category: Infectious Diseases Source Type: research

Spread of ESBL-producing Escherichia coli in nursing home residents in Ireland and the Netherlands may reflect infrastructural differences
Publication date: Available online 9 May 2019Source: Journal of Hospital InfectionAuthor(s): Elisabeth M. Terveer, Muireann Fallon, Margriet E.M. Kraakman, Angela Ormond, Margaret Fitzpatrick, Monique A.A. Caljouw, Alan Martin, Sofie M. van Dorp, Man C. Wong, Ed J. Kuijper, Fidelma FitzpatrickSummaryA prevalence study in two nursing homes (ine each in the Netherlands and Ireland) found four (11%) Dutch and six (9%) Irish residents colonised with 11 extended-spectrum B-lactamase (ESBL)-producing Escherichia coli, ten containing CTX-M-15. Four Dutch isolates, from three residents of the same ward belonged to E. coli O25:H4, ...
Source: Journal of Hospital Infection - May 11, 2019 Category: Infectious Diseases Source Type: research

Cross-sectional study of the prevalence, causes and management of hospital-onset diarrhoea
Publication date: Available online 8 May 2019Source: Journal of Hospital InfectionAuthor(s): Damian Mawer, Fiona Byrne, Sarah Drake, Claire Brown, Alison Prescott, Ben Warne, Rachel Bousfield, Jordan P. Skittrall, Isobel Ramsay, Donald Somasunderam, Moira Bevan, Julie Coslett, Jyothi Rao, Philip Stanley, Adrian Kennedy, Rosemarie Dobson, Sandra Long, Tobi Obisanya, Taher Esmailji, Christina PetridouSummaryBackgroundThe National Health Service in England advises hospitals collect data on hospital-onset diarrhoea (HOD). Contemporaneous data on HOD are lacking.AimTo investigate prevalence, aetiology and management of HOD on m...
Source: Journal of Hospital Infection - May 9, 2019 Category: Infectious Diseases Source Type: research

Service evaluation of alcohol release door plates – an addition to hand hygiene
Publication date: Available online 7 May 2019Source: Journal of Hospital InfectionAuthor(s): M.H. Wilcox, A. DycheSummaryWe designed a service evaluation to examine the effect of installation of alcohol-releasing Surfaceskins doorplates on routine alcohol hand gel hygiene use by healthcare workers. There was an approximate doubling increase in healthcare worker use of alcohol hand gel dispensers following the installation of Surfaceskins doorplates in two operating theatre suites. We found no evidence that Surfaceskins doorplates replaced routine hand hygiene. We conclude that these devices represent a useful adjunct to ro...
Source: Journal of Hospital Infection - May 8, 2019 Category: Infectious Diseases Source Type: research

Ultraclean air systems and the claim that laminar airflow systems fail to prevent deep infections after total joint arthroplasty
Publication date: Available online 3 May 2019Source: Journal of Hospital InfectionAuthor(s): B. Lytsy, W. WhyteSummaryThe World Health Organization published guidelines in 2016 for preventing surgical site infections. The guidelines contained a conditional recommendation that laminar airflow (LAF) ventilation systems should not be used to reduce the risk of infection after total joint arthroplasty (TJA). This recommendation was largely based on a systematic review and meta-analysis of information from hospital infection surveillance registries. The recommendation contradicts information published in earlier major studies c...
Source: Journal of Hospital Infection - May 5, 2019 Category: Infectious Diseases Source Type: research

Faecal microbiota transplantation for the decolonization of antibiotic-resistant bacteria in the gut: a systematic review and meta-analysis
Publication date: Available online 26 March 2019Source: Journal of Hospital InfectionAuthor(s): V. TavoukjianSummaryAntibiotic resistance is a growing global problem associated with increased morbidity and mortality, and presents a significant financial and economic burden on healthcare. Faecal microbiota transplantation (FMT) has been proven effective for curing recurrent Clostridium difficile infections, however no systematic review to date has addressed its effectiveness for decolonization of antibiotic-resistant bacteria from the gut. The aim of this study was to establish whether faecal microbiota transplantation deco...
Source: Journal of Hospital Infection - May 3, 2019 Category: Infectious Diseases Source Type: research

Molecular epidemiology study on a nosocomial Moraxella catarrhalis outbreak in a neurological rehabilitation unit
ConclusionWe report the first M. catarrhalis outbreak involving 9 patients of a neurologic and trauma rehabilitation centre. Potential transmission pathways are discussed. Comprehensive outbreak analyses insinuate extension of routine laboratory storage time for defined species. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 3, 2019 Category: Infectious Diseases Source Type: research

Effects of the prophylactic use of taurolidine-citrate lock on the number of catheter related infections in children under two years of age undergoing surgery
Publication date: Available online 2 May 2019Source: Journal of Hospital InfectionAuthor(s): Łyszkowska Małgorzata, Kowalewski Grzegorz, Szymczak Marek, Polnik Dariusz, Mikołajczyk Agata, Kaliciński PiotrSummaryCentral venous access poses a risk of developing CRIs. The aim of the study was to evaluate prophylactic use of taurolidine-citrate (T-C) solution on the number of CRIs. 97 catheters, used in 86 children, were randomly divided into 2 groups: T(-) (n=49) - standard aseptic procedures; T(+) (n=48) – additional filling of the catheters with T-C solution during intervals in the cycles of parenteral nutrition o...
Source: Journal of Hospital Infection - May 3, 2019 Category: Infectious Diseases Source Type: research

Association of malnutrition with periprosthetic joint and surgical site infections after total joint arthroplasty: a systematic review and meta-analysis
ConclusionMalnutrition is associated with periprosthetic joint and surgical site infections after total joint arthroplasty. Further high-quality research is warranted to confirm or refute these findings. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 3, 2019 Category: Infectious Diseases Source Type: research

Antibiotic prophylaxis in spine surgery: a comparison of single-dose and 72-hour protocols
Publication date: Available online 30 April 2019Source: Journal of Hospital InfectionAuthor(s): Andrzej Maciejczak, Andzelina Wolan-Nieroda, Marta Wałaszek, Małgorzata Kołpa, Zdzisław WolakAbstractBackgroundDespite general consensus on the use of single dose antimicrobial prophylaxis (AMP) in instrumented spine surgery, evidence supporting this approach is not robust.AimTo compare the efficacies of single-dose and 72-hour AMP protocols for the prevention of surgical site infection (SSI) in instrumented (ISS) in a before-and-after study.MethodsProspective non-randomized cohort study on 5208 patients who underwent spine ...
Source: Journal of Hospital Infection - May 2, 2019 Category: Infectious Diseases Source Type: research

J. Henderson et al. Community prevalence of carbapenemase-producing organisms in East London
ConclusionTo date, there have been no studies investigating the prevalence of CPOs in the UK community. Given the high-risk patient population served by Barts Health NHS Trust, it is reassuring that the prevalence observed here was low. However, it should be highlighted that travel to countries not previously categorized as high risk may also pose a threat. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - April 30, 2019 Category: Infectious Diseases Source Type: research

Epidemiology and health-economic burden of urinary catheter-associated infection in English NHS hospitals: a probabilistic modelling study
ConclusionsHospital catheter prevention is poised to reap substantial health-economic gains, but community-oriented interventions are needed to target the large burden imposed by community-onset infection. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - April 30, 2019 Category: Infectious Diseases Source Type: research

Preventing Escherichia coli Bacteraemia through Improved Community Urinary Tract Infection (UTI) Management – Use of the TARGET Uncomplicated UTI audit tool in Primary Care
Publication date: Available online 28 April 2019Source: Journal of Hospital InfectionAuthor(s): Emma Wiley, Corinna Smith, Janaki Thakerar, Peter Wilson (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - April 29, 2019 Category: Infectious Diseases Source Type: research

Dissemination of NDM-1 carbapenemase-producer Providencia stuartii strains in Romanian hospitals – a multicentre study
Publication date: Available online 27 April 2019Source: Journal of Hospital InfectionAuthor(s): Molnár Szabolcs, Flonta Mirela Maria Margareta, Almaș Ariana, Buzea Mariana, Licker Monica, Rus Maria, Földes Annamaria, Székely EditSummarySeveral Romanian hospitals noted increasing isolation of Providencia stuartii strains in recent years, with an alarming rate of carbapenem-resistance. In order to provide molecular epidemiological data regarding their dissemination, we analyzed 77 P. stuartii strains collected from 5 hospitals located in different regions of Romania. All strains harbored IncA/C plasmid, a...
Source: Journal of Hospital Infection - April 29, 2019 Category: Infectious Diseases Source Type: research

Tracking Staphylococcus aureus in ICU using Whole-Genome Sequencing
This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).MethodsSelected hand-touch surfaces, staff hands and air were systematically screened ten times during ten months, with patients screened throughout the study. S. aureus isolates were subjected to spa typing and epidemiological analyses, followed by whole-genome sequencing (WGS) to provide single nucleotide polymorphism (SNP) data.ResultsMultiple transmission pathways between patients and reservoirs were investigated. There were 34 transmission events, of which 29 were highly related (
Source: Journal of Hospital Infection - April 29, 2019 Category: Infectious Diseases Source Type: research

Predicting acquisition of carbapenem-resistant Gram-negative pathogens in intensive care units
ConclusionFinding risk factors and developing predictive models may benefit patients through early detection and by controlling the spread of MDR. The presence of mechanical ventilation and central venous catheter were the main risk factors desmotrated, and their use requires special attention. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - April 29, 2019 Category: Infectious Diseases Source Type: research