Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy.

Self-reported beta-lactam intolerance: not a class effect, dangerous to patients, and rarely allergy. Expert Rev Anti Infect Ther. 2019 May 08;: Authors: Vyles D, Macy E Abstract INTRODUCTION: About 8% of the United States population carries an unconfirmed penicillin "allergy" in their medical record. Many physicians needlessly avoid other beta-lactam use in individuals with unconfirmed penicillin allergies. There is a significantly increased risk of developing serious antibiotic-resistant infections, and increased morbidity and mortality in those who report penicillin allergy. Areas covered: Within this study we reviewed the relevant literature on self-reported beta-lactam allergy. We discuss how the myth of serious allergy to penicillin developed and then discuss and in detail clinically-significant immunologically-mediated hypersensitivity reactions. Following this discussion, we delineate the risks of not using a beta-lactam when it is the drug of choice and then discuss the epidemiology of beta-lactam associated anaphylaxis, serious cutaneous adverse reactions, and serious systemic immunologically-mediated reactions. Following these topics, we further discuss the consensus current best practices to de-label patients with reported penicillin allergy. Expert opinion: An unconfirmed allergy to penicillin offers considerable harm to patients. Many patients have low-risk allergy symptoms to penicillin who could likely tolerate the medication wit...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

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Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
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Chances are, you or someone you know is one of the 10% of Americans with a documented penicillin allergy. But just because you were told you had a penicillin allergy, or had one in the past, does not mean you have one now. People with a penicillin allergy history have their allergy disproved with allergy testing more than 90% of the time. Penicillin: a primer Penicillin is part of a larger drug class called beta-lactam antibiotics, which include the common penicillins and cephalosporins. Common penicillins include ampicillin, amoxicillin, and Augmentin. Among other uses, penicillins are often used to treat ear infections, ...
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CONCLUSIONS: With the numbers available, vancomycin alone during elective primary TJA does not seem to result in a higher rate of subsequent deep SSI. However, patients who received vancomycin alone demonstrated reduced odds of Gram-positive organisms and methicillin-resistant Staphylococcus aureus. Vancomycin monotherapy can be used without increasing the risk of deep SSI; however, it should only be used in patients who require vancomycin, eg, anaphylactic reactions to penicillin resulting from the potential for the emergence of organism resistance and nephrotoxicity. Future studies are needed that use registry and large ...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
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