The democratisation of de-labelling: a review of direct oral challenge in adults with low-risk penicillin allergy.

The democratisation of de-labelling: a review of direct oral challenge in adults with low-risk penicillin allergy. Expert Rev Anti Infect Ther. 2020 Jul 14;: Authors: Rose MT, Slavin M, Trubiano J Abstract INTRODUCTION: Penicillin antibiotic allergy labels (AALs) are common and lead to significant negative health and health system outcomes. Direct oral challenge offers a rapid and cost-effective way of removing inaccurate AALs and improving outcomes. AREAS COVERED: A narrative review (Medline, May 2020) of direct oral challenge in low-risk penicillin allergy in adults is described and the evidence for the safety and efficacy of this approach in inpatients, outpatients and special patient groups is presented. EXPERT OPINION: Whilst the current literature demonstrates the safety and efficacy of direct oral challenge in de-labelling low-risk penicillin allergy in adults, novel approaches are needed to improve access to antibiotic allergy assessment and address the growing global need. PMID: 32662696 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research