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Source: Frontiers in Immunology
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Total 269 results found since Jan 2013.
Corrigendum: The human milk proteome and allergy of mother and child: exploring associations with protein abundances and protein network connectivity
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy
ConclusionOur results showed IgE cross-reactivity of tropomyosin between Dermatophagoides and coho salmon which illustrates salmon allergy following sensitization with the house dust mite Dermatophagoides. Our method for identifying IgE cross-reactive allergens will help understand the underlying mechanisms of food allergies.
Source: Frontiers in Immunology - August 30, 2023 Category: Allergy & Immunology Source Type: research
Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia
Eosinophils are important mediators of mucosal tissue homeostasis, anti-helminth responses, and allergy. Lung eosinophilia has previously been linked to aberrant Type 2-skewed T cell responses to respiratory viral infection and may also be a consequence of vaccine-associated enhanced respiratory disease (VAERD), particularly in the case of respiratory syncytial virus (RSV) and the formalin-inactivated RSV vaccine. We previously reported a dose-dependent recruitment of eosinophils to the lungs of mice vaccinated with alum-adjuvanted trivalent inactivated influenza vaccine (TIV) following a sublethal, vaccine-matched H1N1 (A...
Source: Frontiers in Immunology - August 4, 2023 Category: Allergy & Immunology Source Type: research
Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial
ConclusionICLIT could ameliorate significantly the allergic symptoms in pediatric patients with an advantage in effectiveness and safety, besides an improved life quality including shortened period of treatment, frequency of drug use and pain perception.Clinical trial registrationhttps://www.chictr.org.cn/, identifier ChiCTR1800017130.
Source: Frontiers in Immunology - August 1, 2023 Category: Allergy & Immunology Source Type: research
Di(2-ethylhexyl) phthalate mediates IL-33 production via aryl hydrocarbon receptor and is associated with childhood allergy development
ConclusionsCord blood IL-33 level was correlated to childhood allergy and associated with maternal DEHP exposure. IL-33 might be a potential target to assess the development of DEHP-related childhood allergic disease. Flavonoids might be the natural antidotes for DEHP.
Source: Frontiers in Immunology - July 21, 2023 Category: Allergy & Immunology Source Type: research
Case Report: A novel IRF2BP2 mutation in an IEI patient with recurrent infections and autoimmune disorders
ConclusionWe identified a novel IRF2BP2 mutation in a family with a member diagnosed with IEI. Immune monitoring and WGS as auxiliary tests are helpful in identifying genetic defects and assisting diagnosis in patients with clinically highly suspected immune abnormalities and deficiencies in inflammation regulation. In addition, mNGS techniques allow a more comprehensive assessment of the pathogenic characteristics of these patients. This report further validates the association of IRF2BP2 deficiency and IEI, and expands IEI phenotypes.
Source: Frontiers in Immunology - June 7, 2023 Category: Allergy & Immunology Source Type: research
Staphylococcus aureus δ-toxin present on skin promotes the development of food allergy in a murine model
ConclusionEven without tape stripping, δ-toxin present on skin enhances epicutaneous sensitization to food allergen in an IL-1α-dependent manner, thereby promoting the development of food allergy.
Source: Frontiers in Immunology - May 19, 2023 Category: Allergy & Immunology Source Type: research
The role of PD-1 signaling in health and immune-related diseases
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. Significantly, the binding partners of PD-1 and its associated ligands are diverse, which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Accumulating evidence has demonstrated the important immunosuppressive role of the PD-1 axis in the tumor microenvironment and in autoimmune diseases. In addition, PD-1 blockades have been approved to treat various cancers, including solid tumors and hematological malignancies. Here, we pr...
Source: Frontiers in Immunology - May 16, 2023 Category: Allergy & Immunology Source Type: research
Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction
Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains unaddressed. To explore whether airway allergy causes alveolar dysfunction that might contribute to the pathology of allergic asthma, alveolar structural and functional alterations were analyzed during house dust mite (HDM)-induced airway allergy in mice, by flow cytometry, light and electron microscopy, monocyte transfer experiments, assessment of intra-alveolarly-located ce...
Source: Frontiers in Immunology - May 10, 2023 Category: Allergy & Immunology Source Type: research
Intermittent fasting protects against food allergy in a murine model via regulating gut microbiota
ConclusionIn an OVA-induced mice FA model, long-term IF may attenuate FA by reducing Th2 inflammation, maintaining the integrity of the intestinal epithelial barrier, and preventing gut dysbiosis.
Source: Frontiers in Immunology - May 9, 2023 Category: Allergy & Immunology Source Type: research
Serological analysis of allergic components of house dust mite provides more insight in epidemiological characteristics and clinical symptom development in North China
ConclusionHDM groups 1 and 2 were the major sensitizing allergens, with group 2 being the most important component relevant to respiratory symptoms in North China. The Der p 10 sensitization tends to increase with age. Der p 21 and Der p 23 might be associated with the development of allergic skin disease and asthma, respectively. Multiple allergen sensitizations increased the risk of allergic asthma.
Source: Frontiers in Immunology - April 27, 2023 Category: Allergy & Immunology Source Type: research
Changes in risk factors for food sensitization in early life: Analysis over a period of 10 years
ConclusionThe effect of FHA and common lifestyle factors on food sensitization did not significantly change during 2009−2019. However, the influence of demographic characteristics on food sensitization has changed since 2009; that is, older age, male gender, and only child are more likely to develop food sensitization, which needs to be considered in future epidemiological surveys.Clinical Trial Registrationhttp://www.chictr.org.cn/, identifier ChiCTR1900024338.
Source: Frontiers in Immunology - March 31, 2023 Category: Allergy & Immunology Source Type: research
Current research into A20 mediation of allergic respiratory diseases and its potential usefulness as a therapeutic target
Allergic airway diseases are characterized by excessive and prolonged type 2 immune responses to inhaled allergens. Nuclear factor κB (NF-κB) is a master regulator of the immune and inflammatory response, which has been implicated to play a prominent role in the pathogenesis of allergic airway diseases. The potent anti-inflammatory protein A20, termed tumor necrosis factor-α-inducible protein 3 (TNFAIP3), exerts its effects by inhibiting NF-κB signaling. The ubiquitin editing abilities of A20 have attracted much attention, resulting in its identification as a susceptibility gene in various autoimmune and inflammatory d...
Source: Frontiers in Immunology - March 28, 2023 Category: Allergy & Immunology Source Type: research
A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages
ConclusionThe mechanisms contributing to rFlaA:Betv1-induced IL-1β secretion from macrophages were shown to be complex, involving both NLRC4- and NLRP3-inflammsomes, as well as NFκB- and SAP/JNK MAP kinase-signaling. Better understanding the mechanisms regulating the activation of immune cells by novel therapeutic candidates like the rFlaA:Betv1 fusion protein will allow us to further improve and develop new treatment strategies when using flagellin as an adjuvant.
Source: Frontiers in Immunology - March 21, 2023 Category: Allergy & Immunology Source Type: research
Breast milk microRNAs: Potential players in oral tolerance development
Breast milk is an essential source of nutrition and hydration for the infant. In addition, this highly complex biological fluid contains numerous immunologically active factors such as microorganisms, immunoglobulins, cytokines and microRNAs (miRNAs). Here, we set out to predict the function of the top 10 expressed miRNAs in human breast milk, focusing on their relevance in oral tolerance development and allergy prevention in the infant. The top expressed miRNAs in human breast milk were identified on basis of previous peer-reviewed studies gathered from a recent systematic review and an updated literature search. The miRN...
Source: Frontiers in Immunology - March 14, 2023 Category: Allergy & Immunology Source Type: research
