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Source: Frontiers in Immunology
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Total 269 results found since Jan 2013.
Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation
ConclusionThis is the first study to report on the action of PHX on THP-1 macrophage polarization and the associated changes in the proteome of these cells.
Source: Frontiers in Immunology - March 13, 2023 Category: Allergy & Immunology Source Type: research
The mast cell: A Janus in kidney transplants
Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge ...
Source: Frontiers in Immunology - February 20, 2023 Category: Allergy & Immunology Source Type: research
Modulation by luminal factors on the functions and migration of intestinal innate immunity
Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowe...
Source: Frontiers in Immunology - February 13, 2023 Category: Allergy & Immunology Source Type: research
Inhibition of pathologic immunoglobulin E in food allergy by EBF-2 and active compound berberine associated with immunometabolism regulation
ConclusionsEBF-2 and its active compound berberine are potent IgE suppressors, associated with cellular regulation of immunometabolism on IgE plasma cells, and may be a potential therapy for IgE-mediated food allergy and other allergic disorders.
Source: Frontiers in Immunology - February 7, 2023 Category: Allergy & Immunology Source Type: research
IgE+ plasmablasts predict the onset of clinical allergy
DiscussionTogether, we describe IgE+ plasmablasts as a reliable and sensitive predictive biomarker of allergic disease development.
Source: Frontiers in Immunology - February 2, 2023 Category: Allergy & Immunology Source Type: research
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies
ConclusionBasophils barely express MRGPRX2 in resting conditions. However, the receptor can be quickly upregulated after stimulation with anti-IgE, fMLP, or after purification, making cells responsive to MRGPRX2 occupation. We anticipate that such “conditioned” basophils constitute a model to explore MRGPRX2 agonism or antagonism, including IDHRs originating from the occupation of this receptor.
Source: Frontiers in Immunology - January 16, 2023 Category: Allergy & Immunology Source Type: research
Immunological consequences of microbiome-based therapeutics
The complex network of microscopic organisms living on and within humans, collectively referred to as the microbiome, produce wide array of biologically active molecules that shape our health. Disruption of the microbiome is associated with susceptibility to a range of diseases such as cancer, diabetes, allergy, obesity, and infection. A new series of next-generation microbiome-based therapies are being developed to treat these diseases by transplanting bacteria or bacterial-derived byproducts into a diseased individual to reset the recipient’s microbiome and restore health. Microbiome transplantation therapy is still in...
Source: Frontiers in Immunology - January 12, 2023 Category: Allergy & Immunology Source Type: research
Oral pretreatment with β-lactoglobulin derived peptide and CpG co-encapsulated in PLGA nanoparticles prior to sensitizations attenuates cow’s milk allergy development in mice
Cow’s milk allergy is a common food allergy among infants. Improved hygiene conditions and loss of microbial diversity are associated with increased risk of allergy development. The intestinal immune system is essential for oral tolerance induction. In this respect, bacterial CpG DNA is known to drive Th1 and regulatory T-cell (Treg) development via Toll-Like-Receptor 9 (TLR-9) signaling, skewing away from the allergic Th2 phenotype. We aimed to induce allergen specific tolerance via oral delivery of poly (lactic-co-glycolic acid) nanoparticles (NP) co-encapsulated with a selected β-lactoglobulin derived peptide (BLG-Pe...
Source: Frontiers in Immunology - January 6, 2023 Category: Allergy & Immunology Source Type: research
Unraveling the role of Breg cells in digestive tract cancer and infectious immunity
Over the past two decades, regulatory B cells (Breg cells or Bregs) have emerged as an immunosuppressive subset of B lymphocytes playing a key role in inflammation, infection, allergy, transplantation, and cancer. However, the involvement of Bregs in various pathological conditions of the gastrointestinal tract is not fully understood and is the subject of much recent research. In this review, we aimed to summarize the current state of knowledge about the origin, phenotype, and suppressive mechanisms of Bregs. The relationship between the host gut microbiota and the function of Bregs in the context of the disturbance of mu...
Source: Frontiers in Immunology - December 23, 2022 Category: Allergy & Immunology Source Type: research
Basophils from allergy to cancer
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more recently in the development of mouse models, have markedly advanced our understanding of these cells. Although dissimilarities between human and mouse basophils persist, the overall findings highlight the growing importance of these cells in health and disease. Indeed, studies continue to support basophils as key participants in IgE-mediated reactions, where they infiltrate inflammatory lesio...
Source: Frontiers in Immunology - December 12, 2022 Category: Allergy & Immunology Source Type: research
Prevalence of parent-reported food allergy among children in China: A population-based cross-sectional survey
ConclusionsA high prevalence of parent-reported FA was observed among children in general primary schools in Jiangxi Province, China. Shrimp, mango, and mollusks were the most common causative foods. The main common symptoms of FA were adverse reactions relating to the skin system. The rate of severe allergic reactions was also high in Jiangxi Children with reported FA. Local standards and policies for the prevention and management of FA need to be adjusted on a timely basis according to actual local conditions.
Source: Frontiers in Immunology - December 12, 2022 Category: Allergy & Immunology Source Type: research
Upregulated antimicrobial immune response mediated by neutrophils in the development from allergic rhinitis to asthma
ConclusionsThe activation of the antimicrobial immune response mediated by neutrophils and the depression of cytotoxicity mediated by natural killer cells may play roles in the progression from AR to asthma.
Source: Frontiers in Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research
Integrative transcriptomic analysis in human and mouse model of anaphylaxis identifies gene signatures associated with cell movement, migration and neuroinflammatory signalling
ConclusionOur study highlights the matched and extensive blood transcriptomic changes and suggests the involvement of discrete cellular components and upregulation of migration and neuroinflammatory pathways during anaphylaxis.
Source: Frontiers in Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research
Precision medicine: The use of tailored therapy in primary immunodeficiencies
Primary immunodeficiencies (PID) are rare, complex diseases that can be characterised by a spectrum of phenotypes, from increased susceptibility to infections to autoimmunity, allergy, auto-inflammatory diseases and predisposition to malignancy. With the introduction of genetic testing in these patients and wider use of next-Generation sequencing techniques, a higher number of pathogenic genetic variants and conditions have been identified, allowing the development of new, targeted treatments in PID. The concept of precision medicine, that aims to tailor the medical interventions to each patient, allows to perform more pre...
Source: Frontiers in Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research
The top 100 most cited articles in the last two decades of atopic dermatitis: A bibliometric analysis
ConclusionsOur study aims to provide physicians and researchers with a historical perspective for the scientific progress of atopic dermatitis, and help clinicians effectively obtain useful articles that have a significant impact on the field of atopic dermatitis.
Source: Frontiers in Immunology - November 30, 2022 Category: Allergy & Immunology Source Type: research
