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Condition: Dermatitis
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Total 8248 results found since Jan 2013.
The Role of Janus Kinase Signaling in the Pathology of Atopic Dermatitis
Atopic dermatitis (AD) is a heterogeneous, chronic, relapsing, inflammatory skin disease associated with considerable physical, psychological, and economic burden. Pathology of AD includes complex interactions involving abnormalities in immune and skin barrier genes, skin barrier disruption, immune dysregulation, microbiome disturbance, and other environmental factors. Many of the cytokines involved in AD pathology, including interleukin (IL) –4, IL-13, IL-22, IL-31, thymic stromal lymphopoietin, and interferon gamma, signal through the Janus kinase–signal transducer and activation of transcription (JAK-STAT) pathway.
Source: Journal of Allergy and Clinical Immunology - August 1, 2023 Category: Allergy & Immunology Authors: Emma Guttman-Yassky, Alan D. Irvine, Patrick M. Brunner, Brian S. Kim, Mark Boguniewicz, Julie Parmentier, Andrew M. Platt, Kenji Kabashima Source Type: research
Allergies Come Clean: The Role of Detergents in Epithelial Barrier Dysfunction
The objective of this review is to examine the role of detergents as a potential risk factor for developing allergic disease.Recent FindingsHerein, we identify key sources of human detergent exposure. We summarize the evidence suggesting a possible role for detergents and related chemicals in initiating epithelial barrier dysfunction and allergic inflammation. We primarily focus on experimental models of atopic dermatitis, asthma, and eosinophilic esophagitis, which show compelling associations between allergic disease and detergent exposure. Mechanistic studies suggest that detergents disrupt epithelial barrier integrity ...
Source: Current Allergy and Asthma Reports - August 1, 2023 Category: Allergy & Immunology Source Type: research
The Impact of Air Pollution on Atopic Dermatitis
AbstractPurpose of ReviewAtopic dermatitis (AD) remains a dermatological disease that imposes a significant burden on society. Air pollution has previously been linked to both the onset and severity of atopic dermatitis. As air pollution remains a critical environmental factor impacting human health, this review seeks to provide an overview of the relationship between different air pollutants and AD.Recent FindingsAD can develop from multiple causes that can be broadly grouped into epidermal barrier dysfunction and immune dysregulation. Air pollution imposes significant health risks and includes a wide variety of pollutant...
Source: Current Allergy and Asthma Reports - August 1, 2023 Category: Allergy & Immunology Source Type: research
Patch Testing to Paraphenylenediamine: The North American Contact Dermatitis Group Experience (1994-2018)
Conclusions: The 24-year percentage of allergic reactions to PPD was 5.6%. PPD allergy was associated with female gender and age >40 years. PPD allergic patients were less likely to be White. Allergic reactions were usually clinically relevant and hair dye was the most frequently identified source.PMID:37523239 | DOI:10.1089/derm.2023.0140
Source: Dermatitis - July 31, 2023 Category: Dermatology Authors: Erin M Warshaw Malina Yamashita Peterson Amber R Atwater Joel G DeKoven Melanie D Pratt James S Taylor Donald V Belsito Jonathan I Silverberg Margo J Reeder Vincent A DeLeo Marie-Claude Houle Cory A Dunnick Jiade Yu Brandon Adler Christen Mowad Nina C Bot Source Type: research
Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention
Maternal probiotic supplementation has a promising effect on atopic dermatitis (AD) prevention in infancy. In the randomised controlled study, Probiotics in the Prevention of Allergy among Children in Trondhei...
Source: Clinical and Molecular Allergy - July 29, 2023 Category: Allergy & Immunology Authors: Dinastry Pramadita Zakiudin, Anne Dorthea Bjerkenes R ø, Vibeke Videm, Torbjørn Øien and Melanie Rae Simpson Tags: Research Source Type: research
Pruritus burden assessment in severe atopic dermatitis patients under dupilumab: response predictor?
Eur Ann Allergy Clin Immunol. 2023 Jul 28. doi: 10.23822/EurAnnACI.1764-1489.308. Online ahead of print.NO ABSTRACTPMID:37503751 | DOI:10.23822/EurAnnACI.1764-1489.308
Source: European Annals of Allergy and Clinical Immunology - July 28, 2023 Category: Allergy & Immunology Authors: R Br ás R Lim ão E Pedro A Lopes Source Type: research
Immunomodulatory Effects of Nanoparticles on Dendritic Cells in a Model of Allergic Contact Dermatitis - Importance of PD-L2 Expression
Res Sq. 2023 Jul 12:rs.3.rs-3069059. doi: 10.21203/rs.3.rs-3069059/v1. Preprint.ABSTRACTNanoparticle (NP) skin exposure is linked to the increased prevalence of allergic contact dermatitis. In prior studies using the mouse contact hypersensitivity (CHS) model, we reported that silica 20 nm (Si20nm) suppressed the allergic response and TiO2 doped with manganese (mTiO2) exacerbated it. In this work, we conducted in vitro experiments using bone marrow-derived dendritic cells (BMDCs) to study the combinatorial effect of the potent 2, 4-dinitrofluorobenzene (DNFB) hapten sensitizer with Si20nm and mTiO2 NPs on BMDC cytotoxicity...
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Angela Wong Lau Jessica Perez Pineda Lisa A DeLouise Source Type: research
Pruritus burden assessment in severe atopic dermatitis patients under dupilumab: response predictor?
Eur Ann Allergy Clin Immunol. 2023 Jul 28. doi: 10.23822/EurAnnACI.1764-1489.308. Online ahead of print.NO ABSTRACTPMID:37503751 | DOI:10.23822/EurAnnACI.1764-1489.308
Source: European Annals of Allergy and Clinical Immunology - July 28, 2023 Category: Allergy & Immunology Authors: R Br ás R Lim ão E Pedro A Lopes Source Type: research
Pediatric Allergic March Supported by Nationwide EHR Data
(MedPage Today) -- A typical allergic march started with atopic dermatitis during infancy and progressed to other allergies later in life, a multi-state study found.
In total, 13.4% of pediatric study participants had two or more allergic conditions...
Source: MedPage Today Allergy - July 27, 2023 Category: Allergy & Immunology Source Type: news
Honey flower dermatitis: Contact allergy to ellagic acid in Melianthuscomosus
Food Chem Toxicol. 2023 Jul 21:113956. doi: 10.1016/j.fct.2023.113956. Online ahead of print.ABSTRACTA case study is reported whereby a patient with no prior allergies developed a strong and spreading delayed-type hypersensitivity reaction to Melianthus plants, nectar and synthetic pigment derived from it after frequent handling of these substances. The lesions improved after treatment with topical steroids and allergen avoidance within 1-2 weeks. Subsequent patch testing with the plants, nectar and synthetic ingredients identified ellagic acid (EA) as the sensitizing agent. This is the first proven case of allergic contac...
Source: Food and Chemical Toxicology - July 23, 2023 Category: Food Science Authors: Puneet Arora Evin T Magner Paul L Bigliardi Source Type: research
From the Pages of AllergyWatch
For this edition of From the Pages of AllergyWatch, I've chosen articles from recent issues of AllergyWatch. The first article, with comments from Dr. Chipps, reports data showing a reduction in exacerbations and infections in asthma patients receiving allergen immunotherapy. The next article, with comments from Dr. Lee, also investigates allergen immunotherapy and improvements in atopic dermatitis. The third article, with comments from Dr. Joshi, is an analysis of the types of infant formula used in the US and the various carbohydrate sources.
Source: Annals of Allergy, Asthma and Immunology - July 18, 2023 Category: Allergy & Immunology Authors: Stanley Fineman, Gerald B. Lee, Bradley E. Chipps, Shyam R. Joshi Tags: Special Series Source Type: research
