Centralized red muscle in < em > Odontaspis ferox < /em > and the prevalence of regional endothermy in sharks
Biol Lett. 2023 Nov;19(11):20230331. doi: 10.1098/rsbl.2023.0331. Epub 2023 Nov 8.ABSTRACTThe order Lamniformes contains charismatic species such as the white shark Carcharodon carcharias and extinct megatooth shark Otodus megalodon, and is of particular interest given their influence on marine ecosystems, and because some members exhibit regional endothermy. However, there remains significant debate surrounding the prevalence and evolutionary origin of regional endothermy in the order, and therefore the development of phenomena such as gigantism and filter-feeding in sharks generally. Here we show a basal lamniform shark,...
Source: Biology Letters - November 7, 2023 Category: Biology Authors: Haley R Dolton Edward P Snelling Robert Deaville Andrew L Jackson Matthew W Perkins Jenny R Bortoluzzi Kevin Purves David J Curnick Catalina Pimiento Nicholas L Payne Source Type: research
Consensus on criteria for acromegaly diagnosis and remission
ConclusionConsensus recommendations highlight new understandings of disordered GH and IGF-I in patients with acromegaly and the importance of expert management for this rare disease. (Source: Pituitary)
Source: Pituitary - November 3, 2023 Category: Endocrinology Source Type: research
Cutis verticis gyrata: A rare cutaneous presenting manifestation of acromegaly
Durairaj Arjunan, Liza Das, Sanjay K Bhadada, Manjul Tripathi, Tarun Narang, Pinaki DuttaIndian Journal of Dermatology 2023 68(5):590-590 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - October 31, 2023 Category: Dermatology Authors: Durairaj Arjunan Liza Das Sanjay K Bhadada Manjul Tripathi Tarun Narang Pinaki Dutta Source Type: research
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
ConclusionThe sAOT is a good predictor tool for assessing response to SRLs and correlates with tumor E-cadherin and SSTR2 expression. Thus, it can be useful in clinical practice for therapeutic decision-making in patients with acromegaly. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 31, 2023 Category: Endocrinology Source Type: research
Assessment of forearm muscles with ultrasound shear wave elastography in patients with acromegaly
ConclusionThe patients with acromegaly have an increased muscle thickness but decreased muscle stiffness in the forearm muscles responsible for elbow flexion. Acromegaly can lead to a permanent deterioration of the muscular structure regardless of the disease activity. (Source: Pituitary)
Source: Pituitary - October 30, 2023 Category: Endocrinology Source Type: research
The effect of acromegaly on thyroid disease
Endocr J. 2023 Oct 25. doi: 10.1507/endocrj.EJ23-0356. Online ahead of print.ABSTRACTLong-term stimulation of thyroid follicular epithelium by high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with acromegaly can lead to thyroid dysfunction, goiter, thyroid nodules, and even thyroid cancer and thyroid-associated ophthalmopathy (TAO). Excessive GH/IGF-1 promotes goiter and thyroid nodule formation, which can be reversed by normalizing the IGF-1 levels with surgery or medical treatment. Whether patients with acromegaly have an increased risk of thyroid cancer remains controversial, and routine thy...
Source: Endocrine Journal - October 25, 2023 Category: Endocrinology Authors: Caiyan Mo Liyong Zhong Source Type: research
Interpreting growth hormone and IGF-I results using modern assays and reference ranges for the monitoring of treatment effectiveness in acromegaly
Standard treatment for acromegaly focuses on the achievement of target absolute levels of growth hormone (GH) and insulin-like growth factor (IGF-I). The appropriateness of these targets when measured using modern assay methods is not well defined. This paper reviews biochemical status assessed using methods available at the time and associated clinical outcomes. GH measurements were shown to provide an indication of changes in tumor size, and failure of GH suppression after glucose stimulation is associated with tumor recurrence. IGF-I levels were more closely associated with changes in symptoms and signs. Reduced GH and ...
Source: Frontiers in Endocrinology - October 25, 2023 Category: Endocrinology Source Type: research
Patterns of enrichment and acceleration in evolutionary rates of promoters suggest a role of regulatory regions in cetacean gigantism
Cetaceans (whales, porpoises, and dolphins) are a lineage of aquatic mammals from which some species became giants. Only recently, gigantism has been investigated from the molecular point of view. Studies focu... (Source: BMC Evolutionary Biology)
Source: BMC Evolutionary Biology - October 24, 2023 Category: Molecular Biology Authors: Felipe A. Silva, Agnello C. R. Picorelli, Giovanna S. Veiga and Mariana F. Nery Tags: Research Source Type: research
Use of speckle tracking echocardiography in evaluating cardiac dysfunction in patients with acromegaly: an update
In recent years, cardiovascular disease has garnered increasing attention as the second leading cause of death in individuals with acromegaly, following malignancy. Identifying cardiac dysfunction early in acromegaly patients for timely intervention has become a focal point of clinical research. Speckle tracking echocardiography, a well-established ultrasound technique, surpasses conventional Doppler ultrasound in its sensitivity to assess both local and global cardiac mechanics. It can accurately detect subclinical and clinical myocardial dysfunction, including myocardial ischemia, ventricular hypertrophy, and valvular ch...
Source: Frontiers in Endocrinology - October 20, 2023 Category: Endocrinology Source Type: research
Correlation between tumor invasion and somatostatin receptor subtypes in acromegaly
CONCLUSIONS: Tumor invasion is negatively correlated with SSTR2 level but is not associated with other SSTR subtypes. Patients with invasive tumors have a poorer response to SSA therapy, which may be due to the low level of SSTR2 expression. Therefore, SSTR2 could be considered as a routine investigative marker for aiding management of postoperative residual tumors.PMID:37856412 | DOI:10.3171/2023.7.JNS23858 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 19, 2023 Category: Neurosurgery Authors: Shaolin Zhang Shun Yao Jinping Chen Farhana Akter Jia Yang Dimin Zhu Ailiang Zeng Wenli Chen Zhigang Mao Yonghong Zhu Haijun Wang Source Type: research
Correlation between tumor invasion and somatostatin receptor subtypes in acromegaly
CONCLUSIONS: Tumor invasion is negatively correlated with SSTR2 level but is not associated with other SSTR subtypes. Patients with invasive tumors have a poorer response to SSA therapy, which may be due to the low level of SSTR2 expression. Therefore, SSTR2 could be considered as a routine investigative marker for aiding management of postoperative residual tumors.PMID:37856412 | DOI:10.3171/2023.7.JNS23858 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 19, 2023 Category: Neurosurgery Authors: Shaolin Zhang Shun Yao Jinping Chen Farhana Akter Jia Yang Dimin Zhu Ailiang Zeng Wenli Chen Zhigang Mao Yonghong Zhu Haijun Wang Source Type: research
