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Effects of Progesterone and Other Gonadal Hormones on Glutamatergic Circuits in the Retina
CONCLUSIONS: Progesterone, but not estrogen or testosterone, activated glutamate release in the mouse retina. Increases in the concentration of progesterone during pregnancy did not induce any detectable change in retinal thickness.PMID:37690823 | DOI:10.1272/jnms.JNMS.2023_90-405
Source: Journal of Nippon Medical School - September 10, 2023 Category: Universities & Medical Training Authors: Mahito Ohkuma Takuma Maruyama Toshiyuki Ishii Nozomi Igarashi Keiko Azuma Tatsuya Inoue Ryo Obata Ei-Ichi Miyachi Makoto Kaneda Source Type: research
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print.ABSTRACTThe retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in the retina. The purpose of this study was to characterize cell-specific expression patterns of RLR proteins in non-human primate (NHP) neural retina tissue and to examine if RLR pathway signaling restricts viral gene delivery transduction. Since RLR protein signaling conv...
Source: Experimental Eye Research - September 9, 2023 Category: Opthalmology Authors: Monica M Sauter Hongyu Noel Curtis R Brandt Source Type: research
Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization
CONCLUSION: Topical Retinol palmitate is a safe and effective drug in cases of chronic SJS with ocular surface keratinisation. It has the potential to reverse keratinisation of the ocular surface and promote development of goblet cells. However, the survival of goblet cells is not long lasting.PMID:37689180 | DOI:10.1016/j.jtos.2023.09.002
Source: The Ocular Surface - September 9, 2023 Category: Opthalmology Authors: Ananya Parampalli Ravindra Rajesh Sinha Aafreen Bari T Velpandian Seema Sen Tushar Agarwal Namrata Sharma Jeewan Singh Titiyal Source Type: research
The RLR intrinsic antiviral system is expressed in neural retina and restricts lentiviral transduction of human Mueller cells
Exp Eye Res. 2023 Sep 7:109647. doi: 10.1016/j.exer.2023.109647. Online ahead of print.ABSTRACTThe retinoic acid-inducible gene I (RIG)-I-like receptor (RLR) family of RNA sensor proteins plays a key role in the innate immune response to viral nucleic acids, including viral gene delivery vectors, but little is known about the expression of RLR proteins in the retina. The purpose of this study was to characterize cell-specific expression patterns of RLR proteins in non-human primate (NHP) neural retina tissue and to examine if RLR pathway signaling restricts viral gene delivery transduction. Since RLR protein signaling conv...
Source: Experimental Eye Research - September 9, 2023 Category: Opthalmology Authors: Monica M Sauter Hongyu Noel Curtis R Brandt Source Type: research
Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization
CONCLUSION: Topical Retinol palmitate is a safe and effective drug in cases of chronic SJS with ocular surface keratinisation. It has the potential to reverse keratinisation of the ocular surface and promote development of goblet cells. However, the survival of goblet cells is not long lasting.PMID:37689180 | DOI:10.1016/j.jtos.2023.09.002
Source: The Ocular Surface - September 9, 2023 Category: Opthalmology Authors: Ananya Parampalli Ravindra Rajesh Sinha Aafreen Bari T Velpandian Seema Sen Tushar Agarwal Namrata Sharma Jeewan Singh Titiyal Source Type: research
SBP1 promotes tumorigenesis of thyroid cancer through TXN/NIS pathway
CONCLUSION: SBP1 promoted tumorigenesis and dedifferentiation of thyroid cancer through positively regulating TXN.PMID:37684566 | DOI:10.1186/s10020-023-00700-y
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jiancang Ma Xin Huang Jinkai Xu Zongyu Li Jingyue Lai Yawei Shen Jun Zhao Xuejun Sun Lieting Ma Source Type: research
Elucidating anti-aging and antioxidant activity of Hydnocarpus anthelmintica on skin aging and cosmeceutical potentials: in silico and in vitro study
CONCLUSION: The results of in-vitro experiments showed the effect of HA extract on oxidative stress reduction and collagenase inhibition. We discovered two main active compounds, luteolin and β-carotene, that may be involved in p53 and MAPK signaling, and showed HA extract activity against oxidative stress and collagenase.PMID:37680148 | DOI:10.2174/1386207326666230901092247
Source: Combinatorial Chemistry and High Throughput Screening - September 8, 2023 Category: Chemistry Authors: Minjee Kim Eunji Lee Young Bong Kim Source Type: research
Clinical features of infectious uveitis in a Tunisian population
CONCLUSION: This study highlighted the causes and clinical features of IU in our setting. Tuberculosis remains one of its most frequent etiologies in Tunisia. However, a larger multicenter national study would allow a more precise evaluation.PMID:37682270
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Rym Maamouri Meriam Beldi Yasmine Houman Mehdi Somai Fatma Boussema Monia Cheour Source Type: research
