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Total 18962 results found since Jan 2013.
Syntaxin 3 is haplosufficient for long-term photoreceptor survival in the mouse retina
Front Ophthalmol (Lausanne). 2023;3:1208805. doi: 10.3389/fopht.2023.1208805. Epub 2023 Jun 14.ABSTRACTBiallelic loss-of-function mutations in the syntaxin 3 gene have been linked to a severe retinal dystrophy in humans that presents in early childhood. In mouse models, biallelic inactivation of the syntaxin 3 gene in photoreceptors rapidly leads to their death. What is not known is whether a monoallelic syntaxin 3 loss-of-function mutation might cause photoreceptor loss with advancing age. To address this question, we compared the outer nuclear layer of older adult mice (≈ 20 months of age) that were heterozygous for sy...
Source: Cancer Control - August 23, 2023 Category: Cancer & Oncology Authors: Mariajose Perez-Hurtado Calvin Dao Amanda E Saenz Ruth Heidelberger Source Type: research
Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia
Am J Physiol Lung Cell Mol Physiol. 2023 Aug 22. doi: 10.1152/ajplung.00154.2023. Online ahead of print.ABSTRACTAbnormal pulmonary vascular development and function in congenital diaphragmatic hernia (CDH) is a significant factor leading to pulmonary hypertension. The lung has marked cellular diversity that is differentially responsive to injury and therapeutic agents. Spatial transcriptomics provides unmatched capability of discerning the differences in the transcriptional signature of these distinct cell subpopulations in the lung with regional specificity. We hypothesized that the distal lung parenchyma (selected as a r...
Source: Am J Physiol Lung Ce... - August 22, 2023 Category: Respiratory Medicine Authors: Krithika Lingappan Oluyinka O Olutoye Abiud Cantu Manuel Eliezer Cantu Gutierrez Nahir Cortes-Santiago J D Hammond Jamie Gilley Joselyn Rojas Quintero Hui Li Francesca Polverino Jason P Gleghorn Sundeep G Keswani Source Type: research
Ocular Neovascularisation in Central Retinal Artery Occlusion (CRAO)
Ir Med J. 2023 Aug 17;116(7):816.NO ABSTRACTPMID:37606506
Source: Ir Med J - August 22, 2023 Category: General Medicine Authors: K McElhinney Z Indrees Source Type: research
Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia
Am J Physiol Lung Cell Mol Physiol. 2023 Aug 22. doi: 10.1152/ajplung.00154.2023. Online ahead of print.ABSTRACTAbnormal pulmonary vascular development and function in congenital diaphragmatic hernia (CDH) is a significant factor leading to pulmonary hypertension. The lung has marked cellular diversity that is differentially responsive to injury and therapeutic agents. Spatial transcriptomics provides unmatched capability of discerning the differences in the transcriptional signature of these distinct cell subpopulations in the lung with regional specificity. We hypothesized that the distal lung parenchyma (selected as a r...
Source: Am J Physiol Lung Ce... - August 22, 2023 Category: Respiratory Medicine Authors: Krithika Lingappan Oluyinka O Olutoye Abiud Cantu Manuel Eliezer Cantu Gutierrez Nahir Cortes-Santiago J D Hammond Jamie Gilley Joselyn Rojas Quintero Hui Li Francesca Polverino Jason P Gleghorn Sundeep G Keswani Source Type: research
Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
CONCLUSIONS: Transgenic hESCs differentiate into hRPE cells and retain sCX3CL1 transgene expression both in vitro and in vivo. Moreover, hRPE cells delivered to the subretinal space of rd10 mice prevented photoreceptor degeneration in a local-acting manner, suggesting that this approach could have applications for preserving photoreceptors in specific subregions of the retina, such as the macula. Overall, our study not only reveals the potential of a combined cell and gene therapy for the treatment of RP, but also the possibility of using hRPE cells to deliver therapeutic biologics in situ to treat diseases over long-term....
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Eric D Jong Sabiha Hacibekiroglu Lily Guo Evan Sawula Biao Li Chengjin Li Margaret T Ho Molly S Shoichet Valerie A Wallace Andras Nagy Source Type: research
Ocular Neovascularisation in Central Retinal Artery Occlusion (CRAO)
Ir Med J. 2023 Aug 17;116(7):816.NO ABSTRACTPMID:37606506
Source: Ir Med J - August 22, 2023 Category: General Medicine Authors: K McElhinney Z Indrees Source Type: research
Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia
Am J Physiol Lung Cell Mol Physiol. 2023 Aug 22. doi: 10.1152/ajplung.00154.2023. Online ahead of print.ABSTRACTAbnormal pulmonary vascular development and function in congenital diaphragmatic hernia (CDH) is a significant factor leading to pulmonary hypertension. The lung has marked cellular diversity that is differentially responsive to injury and therapeutic agents. Spatial transcriptomics provides unmatched capability of discerning the differences in the transcriptional signature of these distinct cell subpopulations in the lung with regional specificity. We hypothesized that the distal lung parenchyma (selected as a r...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 22, 2023 Category: Cytology Authors: Krithika Lingappan Oluyinka O Olutoye Abiud Cantu Manuel Eliezer Cantu Gutierrez Nahir Cortes-Santiago J D Hammond Jamie Gilley Joselyn Rojas Quintero Hui Li Francesca Polverino Jason P Gleghorn Sundeep G Keswani Source Type: research
