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Total 18962 results found since Jan 2013.
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Molecular genetic diagnostics for inherited retinal dystrophies in the clinical setting
CONCLUSIONS: This study represents the largest review of molecular genetic testing in IRDs in Canada. That negative or inconclusive results obtained in approximately 45% of cases demonstrates that there is an important need for new research into molecular genetic causes of IRDs This is particularly true in addressing the problem of interpreting a variant of uncertain significance in ethnic minorities.PMID:37678418 | DOI:10.1016/j.jcjo.2023.08.006
Source: Canadian Journal of Ophthalmology - September 7, 2023 Category: Opthalmology Authors: Olubayo U Kolawole Albert Huang Cheryl Y Gregory-Evans Maheshver Shunmugam Travers Weaver Kevin Gregory-Evans Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Biol Sci Space - September 7, 2023 Category: Science Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination
Singapore Med J. 2023 Aug 22. doi: 10.4103/singaporemedj.SMJ-2021-430. Online ahead of print.NO ABSTRACTPMID:37675679 | DOI:10.4103/singaporemedj.SMJ-2021-430
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Duoduo Wu Blanche Xiao Hong Lim Dawn Ka-Ann Lim Gopal Lingam Chris Hong Long Lim Source Type: research
Intravitreal immunotherapy in noninfectious uveitis: an update
Expert Rev Clin Pharmacol. 2023 Sep 6. doi: 10.1080/17512433.2023.2256660. Online ahead of print.ABSTRACTINTRODUCTION: In the past several years, there have been numerous advances in pharmacotherapeutics for the management of uveitis and other ocular inflammatory diseases, including newer therapeutic agents and ocular drug delivery systems. One of the most attractive modes of drug delivery is the intravitreal route since it has proven to be safe and efficacious and prevents unwanted systemic adverse events related to the agent.AREAS COVERED: In this review, intravitreal delivery of various pharmacotherapeutic agents for no...
Source: Pharmacological Reviews - September 7, 2023 Category: Drugs & Pharmacology Authors: Nitin Kumar Menia Sashwanthi Mohan Aniruddha Agarwal Source Type: research
Retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination
Singapore Med J. 2023 Aug 22. doi: 10.4103/singaporemedj.SMJ-2021-430. Online ahead of print.NO ABSTRACTPMID:37675679 | DOI:10.4103/singaporemedj.SMJ-2021-430
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Duoduo Wu Blanche Xiao Hong Lim Dawn Ka-Ann Lim Gopal Lingam Chris Hong Long Lim Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination
Singapore Med J. 2023 Aug 22. doi: 10.4103/singaporemedj.SMJ-2021-430. Online ahead of print.NO ABSTRACTPMID:37675679 | DOI:10.4103/singaporemedj.SMJ-2021-430
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Duoduo Wu Blanche Xiao Hong Lim Dawn Ka-Ann Lim Gopal Lingam Chris Hong Long Lim Source Type: research
hPSC-derived RPE transplantation for the treatment of macular degeneration
Prog Mol Biol Transl Sci. 2023;199:227-269. doi: 10.1016/bs.pmbts.2023.02.010. Epub 2023 Mar 14.ABSTRACTMacular degeneration (MD) is a group of diseases characterized by irreversible and progressive vision loss. Patients with MD suffer from severely impaired central vision, especially elderly people. Currently, only one type of MD, wet age-related macular degeneration (AMD), can be treated with anti-vascular endothelium growth factor (VEGF) drugs. Other types of MD remain difficult to treat. With the advent of human pluripotent stem cells (hPSCs) and their differentiation into retinal pigmented epithelium (RPE), it is prom...
Source: Biol Sci Space - September 7, 2023 Category: Science Authors: Qian Liu Jun Liu Akon Higuchi Source Type: research
Molecular genetic diagnostics for inherited retinal dystrophies in the clinical setting
CONCLUSIONS: This study represents the largest review of molecular genetic testing in IRDs in Canada. That negative or inconclusive results obtained in approximately 45% of cases demonstrates that there is an important need for new research into molecular genetic causes of IRDs This is particularly true in addressing the problem of interpreting a variant of uncertain significance in ethnic minorities.PMID:37678418 | DOI:10.1016/j.jcjo.2023.08.006
Source: Canadian Journal of Ophthalmology - September 7, 2023 Category: Opthalmology Authors: Olubayo U Kolawole Albert Huang Cheryl Y Gregory-Evans Maheshver Shunmugam Travers Weaver Kevin Gregory-Evans Source Type: research
Retinal vein occlusion following BNT162b2 (Pfizer-BioNTech) COVID-19 vaccination
Singapore Med J. 2023 Aug 22. doi: 10.4103/singaporemedj.SMJ-2021-430. Online ahead of print.NO ABSTRACTPMID:37675679 | DOI:10.4103/singaporemedj.SMJ-2021-430
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Duoduo Wu Blanche Xiao Hong Lim Dawn Ka-Ann Lim Gopal Lingam Chris Hong Long Lim Source Type: research
