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Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess
Endocrinology. 2023 Sep 21:bqad141. doi: 10.1210/endocr/bqad141. Online ahead of print.ABSTRACTHyperandrogenemia and polycystic ovarian syndrome are a result of the imbalance of androgen levels in females. Androgen receptor (Ar) mediates the effect of androgen, and this study examines how neuronal Ar in the central nervous system (CNS) mediates metabolism under normal and increased androgen conditions in female mice. The neuron specific ARKO mouse (SynARKO) was created from female (Ar fl/wt; synapsin promoter driven Cre) and male (Ar fl/y) mice. Glucose tolerance test revealed impaired glucose tolerance that was partially ...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Vaibhave Ubba Serene Joseph Olubusayo Awe Dustin Jones Milan K Dsilva Mingxiao Feng Junjiang Wang Xiaomin Fu Razeen J Akbar Brittany H Bodnar Wenhui Hu Hong Wang Xiaofeng Yang Ling Yang Peixin Yang Rexford Ahima Sara Divall Sheng Wu Source Type: research
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Targeting the NAD+ Salvage Pathway: Synergistic Therapeutic Strategy for ER+ Metastatic Breast Cancer
Endocrinology. 2023 Sep 20:bqad140. doi: 10.1210/endocr/bqad140. Online ahead of print.NO ABSTRACTPMID:37738166 | DOI:10.1210/endocr/bqad140
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Rebecca B Riggins Suman Ranjit Source Type: research
Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma
CONCLUSION: The pathogenesis of STS including FN-RMS remains poorly understood, emphasizing the need for new therapeutic advances and adequate risk stratification. Our data demonstrate that loss of chr3q is associated with poor OS in FN-RMS, supporting it as an important tool for risk stratification.PMID:37738543 | DOI:10.1200/PO.23.00037
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Carina A Dehner Robert C Bell Yang Cao Kevin He John S A Chrisinger Amy E Armstrong Marielle Yohe Jack Shern Angela C Hirbe Source Type: research
Correction: Liver Transplantation After Hepatic Artery Infusion Pump Therapy: Single-Center Experience and Technical Considerations
Ann Surg Oncol. 2023 Sep 22. doi: 10.1245/s10434-023-14351-0. Online ahead of print.NO ABSTRACTPMID:37737969 | DOI:10.1245/s10434-023-14351-0
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Angela L Hill Darren R Cullinan Ola Ahmed Neeta Vachharajani Meranda D Scherer Franklin Olumba Adeel S Khan William C Chapman Majella B Doyle Source Type: research
Fragmentation of Care in Patients with Peritoneal Metastases Undergoing Cytoreductive Surgery
CONCLUSIONS: There were no significant differences in survival or SAEs based on the networks of systemic therapy delivery. This suggests that patients undergoing CRS at a high-volume center may safely receive systemic therapy at outside-network facilities with comparable outcomes.PMID:37737968 | DOI:10.1245/s10434-023-14318-1
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Mason Vierra Varun V Bansal Ryan B Morgan Hunter D D Witmer Biren Reddy Ankit Dhiman Frederick A Godley Cecilia T Ong Erika Belmont Blas é Polite Ardaman Shergill Kiran K Turaga Oliver S Eng Source Type: research
ASO Visual Abstract: De-Implementation of Low-Value Care in Women ≥ 70 Years with Low-Risk Breast Cancer During the COVID-19 Pandemic
Ann Surg Oncol. 2023 Sep 21. doi: 10.1245/s10434-023-14329-y. Online ahead of print.NO ABSTRACTPMID:37735322 | DOI:10.1245/s10434-023-14329-y
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Ton Wang Christina Weed Joshua Tseng Alice Chung Marissa K Boyle Farin Amersi Jaswinder Jutla Amin Mirhadi Armando E Giuliano Source Type: research
ASO Visual Abstract: Robotic Klatskin Type 3A Resection with Biliary Reconstruction-Description of Surgical Technique and Outcomes of Initial Series
Ann Surg Oncol. 2023 Sep 21. doi: 10.1245/s10434-023-14324-3. Online ahead of print.NO ABSTRACTPMID:37735321 | DOI:10.1245/s10434-023-14324-3
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Iswanto Sucandy Ahmed Younos Allyson Lim-Dy Sharona Ross Alexander Rosemurgy Source Type: research
Evaluating the dosimetric effect of intra-fractional variations in deep inspiration breath-hold radiotherapy - a proof-of-concept study
Acta Oncol. 2023 Sep 22:1-5. doi: 10.1080/0284186X.2023.2259084. Online ahead of print.NO ABSTRACTPMID:37738385 | DOI:10.1080/0284186X.2023.2259084
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: K H åkansson M Josipovic W Ottosson C P Behrens I R Vogelius G Persson Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Accuracy of Essential TNM to stage large colorectal (T3/T4) cancers in absence of nodal status information
Acta Oncol. 2023 Sep 22:1-3. doi: 10.1080/0284186X.2023.2257376. Online ahead of print.NO ABSTRACTPMID:37738263 | DOI:10.1080/0284186X.2023.2257376
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Marion Pi ñeros James Brierley Enrique Barrios Patricia Cueva Carina Musetti Constanza Pardo Kevin Ward D Maxwell Parkin Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
A Survey of the Status of Methadone Switching in Japan Using a Hospital-Based Administrative Claims Database
In conclusion, more than 30% of the patients underwent high-dose methadone switching and required long completion periods, suggesting that methadone switching remains challenging in Japan. This article is protected by copyright. All rights reserved.PMID:37737471 | DOI:10.1002/jcph.2351
Source: The Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Authors: Shungo Imai Natsumi Aoki Keisuke Ikegami Hayato Kizaki Satoko Hori Source Type: research
Artificial Intelligence for Drug Discovery: Are We There Yet?
Annu Rev Pharmacol Toxicol. 2023 Sep 22. doi: 10.1146/annurev-pharmtox-040323-040828. Online ahead of print.ABSTRACTDrug discovery is adapting to novel technologies such as data science, informatics, and artificial intelligence (AI) to accelerate effective treatment development while reducing costs and animal experiments. AI is transforming drug discovery, as indicated by increasing interest from investors, industrial and academic scientists, and legislators. Successful drug discovery requires optimizing properties related to pharmacodynamics, pharmacokinetics, and clinical outcomes. This review discusses the use of AI in ...
Source: Annual Review of Pharmacology and Toxicology - September 22, 2023 Category: Drugs & Pharmacology Authors: Catrin Hasselgren Tudor I Oprea Source Type: research
