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Effects of Photobiomodulation Therapy on Lung Function and Inflammatory Factors in Patients with COVID-19 During Acute Stage
Conclusions: Application of photobiomodulation is recommended for treatment of respiratory problems in patients with COVID-19 to improve clinical signs and control inflammatory factors. Clinical Trial Registration: IRCT2017070934969N1.PMID:37738370 | DOI:10.1089/photob.2022.0157
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fatemeh Ehsani Rasool Bagheri Mahbubeh Darban Maral Hemati Mohammad Bahrami Fatemeh Sharafieh Source Type: research
Regulatory circuits of mitophagy restrict distinct modes of cell death during memory CD8 < sup > + < /sup > T cell formation
Sci Immunol. 2023 Sep 29;8(87):eadf7579. doi: 10.1126/sciimmunol.adf7579. Epub 2023 Sep 22.ABSTRACTMitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of memory CD8+ T cells rely on oxidative metabolism, a process that requires robust mitochondrial quality control. Here, we found that Parkinson's disease patients have a reduced frequency of CD8+ memory T cells compared with healthy donors and failed to form memory T cells upon vaccination against COVID-19, highli...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Fabien Franco Alessio Bevilacqua Ruey-Mei Wu Kung-Chi Kao Chun-Pu Lin Lor ène Rousseau Fu-Ti Peng Yu-Ming Chuang Jhan-Jie Peng Jaeoh Park Yingxi Xu Antonino Cassotta Yi-Ru Yu Daniel E Speiser Federica Sallusto Ping-Chih Ho Source Type: research
Taxane-Based Chemotherapy Is Effective in Metastatic Appendiceal Adenocarcinoma
Oncologist. 2023 Sep 20:oyad263. doi: 10.1093/oncolo/oyad263. Online ahead of print.ABSTRACTAppendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that t...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Julia Dansby Aditya More Mohammad Zeineddine Abdelrahman Yousef Alisha Bent Farshid Dayyani Robert Wolff Michael Overman John Paul Shen Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Recommendations on data sharing in HIV drug resistance research
PLoS Med. 2023 Sep 22;20(9):e1004293. doi: 10.1371/journal.pmed.1004293. Online ahead of print.ABSTRACTAuthor summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect ant...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seth C Inzaule Mark J Siedner Susan J Little Santiago Avila-Rios Alisen Ayitewala Ronald J Bosch Vincent Calvez Francesca Ceccherini-Silberstein Charlotte Charpentier Diane Descamps Susan H Eshleman Joseph Fokam Lisa M Frenkel Ravindra K Gupta John P A Io Source Type: research
Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer
In this study, we investigate the contribution of rare variants (RVs) (minor allele frequency <0.01) to lung cancer through two large whole exome sequencing case-control studies. We first performed gene-based association tests using a novel Bayes Factor statistic in the International Lung Cancer Consortium, the discovery study (European, 1042 cases vs. 881 controls). The top genes identified are further assessed in the UK Biobank (European, 630 cases vs. 172 864 controls), the replication study. After controlling for the false discovery rate, we found two genes, CTSL and APOE, significantly associated with lung cancer i...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Jingxiong Xu Wei Xu Jiyeon Choi Yonathan Brhane David C Christiani Jui Kothari James McKay John K Field Michael P A Davies Geoffrey Liu Christopher I Amos Rayjean J Hung Laurent Briollais Source Type: research
Decentralizing cancer care in sub-Saharan Africa through an integrated regional cancer centre model: The case of Kenya
This study aimed to analyze the status of the utilization of services at regional cancer centers. We analyzed data from the district health information system, focusing on patient demographics, visit type, cancer stage, and the type of treatment provided. For comparison, a trend analysis of new cancer cases recorded at the main national referral hospital between 2011-2021 was also conducted. We conducted a descriptive analysis of the variables of interest; the median was used to summarize continuous variables and percentages were used for categorical variables. A total of 29,321 patients visited the regional centers in 202...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mary F Nyangasi Angela A McLigeyo David Kariuki Siwillis Mithe Albert Orwa Valerian Mwenda Source Type: research
Risk of thromboembolic events associated with different multiple myeloma regimens in Taiwan: a nested case-control study
J Thromb Thrombolysis. 2023 Sep 22. doi: 10.1007/s11239-023-02887-7. Online ahead of print.ABSTRACTAlthough novel agents for multiple myeloma (MM) have a better response rate and survival in both newly diagnosed and relapsed/refractory MM patients, concerns regarding the association between MM treatments and thromboembolic events have been raised. The aim of this population-based study was to examine the association between different combinations of MM treatments and the risk of thromboembolic events. We conducted a nested case-control study using the Taiwan Cancer Registry (TCR) and National Health Insurance Research Data...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mei-Tsen Chen Shih-Tsung Huang Huai-Hsuan Huang Wen-Jone Chen Bor-Sheng Ko Fei-Yuan Hsiao Source Type: research
Rapid Detection of bla < sub > KPC < /sub > in Carbapenem-Resistant Enterobacterales Based on CRISPR/Cas13a
In conclusion, the RPA-Cas13a system is a simple and one-hour efficient technology for the detection of a potentially fatal antibiotic resistance gene.PMID:37737960 | DOI:10.1007/s00284-023-03457-z
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mingjun Liang Bin Xiao Lidan Chen Xiaoyan Huang Jinchao Li Zhenzhan Kuang Xinping Chen Xiuna Huang Zhaohui Sun Linhai Li Source Type: research
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
CONCLUSIONS: The use of comprehensive pre-treatment staging, including laparoscopy and 18F-FDG-PET/CT scan, is an effective approach in identifying occult metastatic disease in LAPC patients. Our findings offer valuable insights into accurate staging and treatment efficacy, providing evidence-based support for optimal management strategies in LAPC patients.PMID:37737898 | DOI:10.1097/JS9.0000000000000755
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michele Fiore Gian Marco Petrianni Pasquale Trecca Gabriele D'Ercole Alessandro Coppola Vincenzo La Vaccara Silvia Taralli Paola Cimini Carlo Greco Edy Ippolito Maria Lucia Calcagni Bruno Beomonte Zobel Damiano Caputo Roberto Coppola Sara Ramella Rolando Source Type: research
Harnessing Dendritic Cells: Next Frontier for Durable Immune Control in Myeloma
Clin Cancer Res. 2023 Sep 22:OF1-OF3. doi: 10.1158/1078-0432.CCR-23-2292. Online ahead of print.ABSTRACTImmune-based approaches including T-cell redirection have transformed the therapeutic landscape in myeloma. Injection of dendritic cells (DC) led to the induction of immune responses in vaccinated patients with myeloma. These studies pave the way for future combination strategies harnessing DCs to enhance tumor immunity and improve outcomes in myeloma. See related article by Freeman et al., p. 000.PMID:37737650 | DOI:10.1158/1078-0432.CCR-23-2292
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Madhav V Dhodapkar Source Type: research
Prevalence and predictors of colorectal cancer screening in the United States: evidence from the HINTS database 2018 to 2020
CONCLUSION: CRC screening rates among adults 45-49 years are low but are increasing steadily. Odds of CRC screening among Blacks is high which is encouraging while the odds among current smokers is low and concerning given their increased risk of developing CRC.PMID:37737304 | DOI:10.1007/s10552-023-01795-8
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Joseph Atarere Christopher Haas Ted Akhiwu Thilini Delungahawatta Ashik Pokharel Comfort Adewunmi Eugene Annor Vwaire Orhurhu Jasmine Barrow Source Type: research
Untargeted serum metabolomic profiles and breast density in young women
CONCLUSION: Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.PMID:37737303 | DOI:10.1007/s10552-023-01793-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seungyoun Jung Sarah Silva Cher M Dallal Erin LeBlanc Kenneth Paris John Shepherd Linda G Snetselaar Linda Van Horn Yuji Zhang Joanne F Dorgan Source Type: research
Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research
