This page shows you your search results in order of date. This is page number 13.
Order by Relevance | Date
Total 5193339 results found since Jan 2013.
The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community-based population: Results based on high-resolution magnetic resonance imaging
CONCLUSIONS: We found that ICAD detected using HR-MRI increases the long-term risk of a first-ever ischemic stroke in a stroke-free population, suggesting that the current primary prevention protocol of stroke awaits further optimization.PMID:37738517 | DOI:10.1111/ene.16057
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Shengde Li Mingyu Tang Dingding Zhang Fei Han Lixin Zhou Ming Yao Mingli Li Liying Cui Shuyang Zhang Bin Peng Zhengyu Jin Yicheng Zhu Jun Ni Source Type: research
Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
CONCLUSIONS: During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.PMID:37738035 | DOI:10.1097/GME.0000000000002245
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Samar R El Khoudary Xirun Chen Ziyuan Wang Maria M Brooks Trevor Orchard Sybil Crawford Imke Janssen Susan A Everson-Rose Daniel McConnell Karen Matthews Source Type: research
Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in < em > Escherichia fergusonii < /em > and confirming its role in TMA production from dietary < em > L- < /em > carnitine in murine models
mBio. 2023 Sep 22:e0093723. doi: 10.1128/mbio.00937-23. Online ahead of print.ABSTRACTTrimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a dual-microbe anaerobic pathway for the metabolism of L-carnitine into TMA, in which the widely distributed cai operon in Enterobacteriaceae converts L-carnitine into gamma-butyrobetaine (γBB), followed by the degradation of γBB into TMA by the relatively rare gamma-butyrobetaine utilization (gbu) gene...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Mohammed Dwidar Jennifer A Buffa Zeneng Wang Akeem Santos Aaron N Tittle Xiaoming Fu Adeline M Hajjar Joseph A DiDonato Stanley L Hazen Source Type: research
Non-Calcified Coronary Artery Plaque on Coronary Computed Tomography Angiogram: Prevalence and Significance
CONCLUSIONS: NCP is the initial precursor of calcified plaque and serves as a prominent marker of early coronary atherosclerosis. By detecting NCP during early stages, several measures can be implemented which can alter the evolutionary course of the underlying disease. This can potentially lead to a lower incidence of cardiovascular events.PMID:37736993 | DOI:10.3390/tomography9050140
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Bandar Alyami Matthew Santer Karthik Seetharam Dhivya Velu Eswar Gadde Bansari Patel Yasmin S Hamirani Source Type: research
Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/ β-catenin pathway in atherosclerosis
In this study, ApoE-/-: Sirt6-/- and ApoE-/-: Sirt6Tg mice were used and lipid droplets were analysed via transmission electron microscopy and Bodipy 493/503 staining in vitro. Atherosclerotic plaques in ApoE-/-: Sirt6-/- mice showed greater necrotic cores and lower stability score. Reconstitution of Sirt6 in atherosclerotic mice improved lipid metabolism disorder and prevented the progression of atherosclerosis. Furthermore, macrophages with Ac-LDL intervention showed more lipid droplets and increased expression of adipophilin and PLIN2. Reconstitution of Sirt6 recruited using SNF2H suppressed Wnt1 expression and improved...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Tingting Wang Zheng Cheng Ran Zhao Jin Cheng He Ren Pengke Zhang Pengyun Liu Qimeng Hao Qian Zhang Xiaolei Yu Dongdong Sun Dongwei Zhang Source Type: research
Female-specific risk factors of parity and menopause age and risk of carotid plaque: the multi-ethnic study of atherosclerosis
CONCLUSION: In a multiethnic cohort, grand multiparity was independently associated with carotid plaque presence and progression. Early menopause, a known risk factor for CVD, was not captured by carotid plaque in this study. These findings may have implications for refining CVD risk assessment in women.PMID:37736349 | PMC:PMC10509453
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Carla P Rodriguez Oluseye Ogunmoroti Anum S Minhas Dhananjay Vaidya Brigitte Kazzi Olatokunbo Osibogun Seamus Whelton Lara C Kovell Colleen M Harrington Michael C Honigberg Ritu Thamman James H Stein Michael D Shapiro Erin D Michos Source Type: research
Human regulatory T cells turn into cytotoxic 'exT < sub > reg < /sub > ' cells in atherosclerosis
Nat Immunol. 2023 Sep 21. doi: 10.1038/s41590-023-01629-4. Online ahead of print.NO ABSTRACTPMID:37735595 | DOI:10.1038/s41590-023-01629-4
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Source Type: research
High-Throughput Screening of the Saccharomyces cerevisiae Genome for 2-Amino-3-Methylimidazo 4,5-f Quinoline Resistance Identifies Colon Cancer-Associated Genes
G3 (Bethesda). 2023 Sep 22:jkad219. doi: 10.1093/g3journal/jkad219. Online ahead of print.ABSTRACTHeterocyclic aromatic amines (HAAs) are potent carcinogenic agents found in charred meats and cigarette smoke. However, few eukaryotic resistance genes have been identified. We used Saccharomyces cerevisiae (budding yeast) to identify genes that confer resistance to 2-amino-3-methylimidazo[4,5-f] quinoline (IQ). CYP1A2 and NAT2 activate IQ to become a mutagenic nitrenium compound. Deletion libraries expressing human CYP1A2 and NAT2 or no human genes were exposed to either 400 or 800 µM IQ for five or ten generations. DNA barc...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michael Dolan Nick St John Faizan Zaidi Francis Doyle Michael Fasullo Source Type: research
Oncologic outcomes of segmentectomy versus lobectomy for clinical T1c radiological pure-solid non-small cell lung cancer
CONCLUSIONS: In T1c radiological pure-solid non-small cell lung cancer, segmentectomy was significantly associated with worse survival and insufficient loco-regional cancer control. Lobectomy remains the standard surgical treatment; meanwhile, segmentectomy should be applied with great caution.PMID:37738593 | DOI:10.1093/icvts/ivad152
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Aritoshi Hattori Kazuya Takamochi Takeshi Matsunaga Mariko Fukui Kenji Suzuki Source Type: research
Paraneoplastic arthritis: a series of 92 cases
CONCLUSION: As a result, although PA is a rare condition, it can be confused with many rheumatological diseases. The most commonly involved joint is the knee joint, followed by the ankle and hand-wrist. Autoantibody negativity, high LDH level, and arthritis unresponsive to treatment constitute important clues for diagnosis.PMID:37738571 | DOI:10.1093/rheumatology/kead500
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: B ünyamin Kısacık Fatih Albayrak Mehmet Ali Balc ı Emrah Koc Source Type: research
Characterization of the Tumor Microenvironment of De Novo Oligometastatic Breast Cancer in a Nationwide Cohort
CONCLUSION: We identified tumor and ECM features in the primary tumor of patients with de novo OMBC that were associated with long-term survival. Our data should be validated in other patients with OMBC before they can be used in clinical practice.PMID:37738542 | DOI:10.1200/PO.22.00670
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Tessa G Steenbruggen Denise M Wolf Bram Thijssen Joyce Sanders Sten Cornelissen Roberto Salgado Lorenza Mittempergher Rajith Bhaskaran Annegien Broeks Esther H Lips Sabine Siesling Gabe S Sonke Hugo M Horlings Laura J van 't Veer Source Type: research
Projection of the number of new liver cancer cases in the world
Jpn J Clin Oncol. 2023 Sep 20:hyad126. doi: 10.1093/jjco/hyad126. Online ahead of print.NO ABSTRACTPMID:37738502 | DOI:10.1093/jjco/hyad126
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Kayo Nakata Sumiyo Okawa Source Type: research
A new method of estimating prevalence of childhood cancer survivors (POCCS): example of the 20-year prevalence in The Netherlands
CONCLUSIONS: Using the POCCS model and aggregated cancer data, our estimates of childhood cancer survivors limited-duration prevalence were consistent with those computed by a standard method requiring individual cancer records. The POCCS method provides relevant information for planning follow-up and care for childhood cancer survivors.PMID:37738448 | DOI:10.1093/ije/dyad124
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Andrea Gini Murielle Colombet Neimar de Paula Silva Otto Visser Danny Youlden Isabelle Soerjomataram Charles A Stiller Eva Steliarova-Foucher CRICCS Consortium Source Type: research
Definitive carbon ion re-irradiation with pencil beam scanning in the treatment of unresectable locally recurrent rectal cancer
In conclusion, definitive carbon ion re-irradiation with PBS provided superior oncologic results with tolerable toxicities and may be served as a curative treatment strategy in unresectable LRRC.PMID:37738440 | DOI:10.1093/jrr/rrad068
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Xin Cai Ping Li Jingfang Zhao Weiwei Wang Jingyi Cheng Guangyuan Zhang Sanjun Cai Zhen Zhang Guoliang Jiang Qing Zhang Zheng Wang Source Type: research
Pregnancy and progression of differentiated thyroid cancer: A propensity score-matched retrospective cohort study
CONCLUSIONS: Pregnancy seemed to be irrelevant to DTC progression-free survival before surgical treatment. Further prospective cohort studies are needed to translate this finding into clinical practice.PMID:37738427 | DOI:10.1210/clinem/dgad557
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Wu-Cai Xiao Xin Li Rui Shan Fang Mei Shi-Bing Song Jing Chen Bang-Kai Sun Chun-Hui Yuan Zheng Liu Source Type: research
