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The role of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis and monitoring of large vessel vasculitides - a review article
Am J Nucl Med Mol Imaging. 2023 Aug 15;13(4):127-135. eCollection 2023.ABSTRACTIn the last two decades, advancements in positron emission tomography (PET) technology have increased the diagnostic accuracy of patients with large-vessel vasculitis (LVV). Numerous systematic reviews and meta-analyses have been conducted, and patients suspected of having LVV can be diagnosed earlier with 18F-FDG PET. Two subtypes, giant cell arteritis (GCA) and Takayasu arteritis (TA), will progress when their response to corticosteroids and enhanced immunosuppression is inadequate. In the majority of patients, disease activity cannot be monit...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Mahshid Bahrami Hossein Mohammadi Hannaneh Mirgaloyebayat Zahra Mohajeri Pooya Fazeli Azad Mojahedi Ali Afsharirad Reza Tavakoli Amirhossein Sadeghian Sayed Mohammad Amin Nourian Source Type: research
Novel technique of detecting inflammatory and osseous changes in the glenohumeral joint associated with patient age and weight using FDG- and NaF-PET imaging
CONCLUSION: Our study demonstrates the varying effect of limb laterality and BMI on FDG and NaF uptake at the GH joint. Adoption of molecular imaging will require future studies that correlate tracer uptake with relevant medical and illness history as well as degenerative change evident on traditional imaging.PMID:37736491 | PMC:PMC10509288
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Peter Sang Uk Park Lori Jia William Y Raynor Om H Gandhi Mia Mijung Park Thomas J Werner Poul Flemming H øilund-Carlsen Abass Alavi Source Type: research
Associated Factors of Tophaceous Gout: A Study Involving 20 Primary Care Clinics in an Urbanized State in Malaysia
CONCLUSIONS: Tophaceous gout is associated with longer disease duration, higher baseline serum uric acid level, and younger age at symptoms onset. Hence, early initiation of urate-lowering therapy with a treat-to-target approach is crucial to prevent tophi formation.PMID:37736055 | PMC:PMC10509634 | DOI:10.5001/omj.2023.87
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Syang Pyng Gan Mollyza Mohd Zain Shereen Suyin Ch'ng Hasliza Hassan Wan Farzihan Wan Adib Anizah Muzaid Ing Soo Lau Habibah Yusoof Azmillah Rosman Hazlyna Baharuddin Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
The anti-inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage
This article is protected by copyright. All rights reserved.PMID:37735964 | DOI:10.1002/biot.202200632
Source: Biotechnology Journal - September 22, 2023 Category: Biotechnology Authors: Yajin Guan Qianqing Chen Jiahuan Xu Boyu Chen Baofang Ou Tianping Liu Shuiling Xie Yanan Bie Source Type: research
Composite Silica-Based Films as Platforms for Electrochemical Sensors
Chem Rec. 2023 Sep 22:e202300194. doi: 10.1002/tcr.202300194. Online ahead of print.ABSTRACTSol-gel-derived silica thin films generated onto electrode surfaces in the form of organic-inorganic hybrid coatings or other composite layers have found tremendous interest for being used as platforms for the development of electrochemical sensors and biosensors. After a brief description of the strategies applied to prepare such materials, and their interest as electrode modifier, this review will summarize the major advances made so far with composite silica-based films in electroanalysis. It will primarily focus on electrochemic...
Source: Chemical Record - September 22, 2023 Category: Chemistry Authors: Oksana Tananaiko Alain Walcarius Source Type: research
Rational Design of Hollow Structural Materials for Sodium-Ion Battery Anodes
Chem Rec. 2023 Sep 21:e202300206. doi: 10.1002/tcr.202300206. Online ahead of print.ABSTRACTThe development of sodium-ion battery (SIB) anodes is still hindered by their rapid capacity decay and poor rate capabilities. Although there have been some new materials that can be used to fabricate stable anodes, SIBs are still far from wide applications. Strategies like nanostructure construction and material modification have been used to prepare more robust SIB anodes. Among all the design strategies, the hollow structure design is a promising method in the development of advanced anode materials. In the past decade, research ...
Source: Chemical Record - September 22, 2023 Category: Chemistry Authors: Chu Qin Zhong-Jie Jiang Thandavarayan Maiyalagan Zhongqing Jiang Source Type: research
Searching for bacteria able to metabolize polycyclic aromatic sulfur compounds in 12-years periodically fed bioreactor
This study aimed to identify microorganisms capable of degrading PASC in such environments. Among the 20 colonies isolated from an inoculum containing DBT as the sole sulfur source, only four isolates exhibited amplification of the dszA gene in the dszABC operon. The production of 2-hydroxybiphenyl (HPB) and a decrease in DBT were detected during the growth curve and resting cell assays. The isolates were identified using 16S rRNA sequencing belonging to the genera Stutzerimonas and Pseudomonas. These isolates demonstrated significant potential for biodesulfurization and/or degradation of PASC. All isolates possessed the p...
Source: Archives of Microbiology - September 22, 2023 Category: Microbiology Authors: Gilberto Matos Neto Eric de Lima Silva Marques Larissa Karen Silva Oliveira Rachel Passos Rezende Jo ão Carlos Teixeira Dias Source Type: research
Impact of ecological stages on the soil microbiota and soil abiotic factors in tropical and subtropical Brazilian regions
Arch Microbiol. 2023 Sep 22;205(10):335. doi: 10.1007/s00203-023-03677-8.ABSTRACTOur aim was to test if ecological stages may influence the arbuscular mycorrhizal fungi (AMF), nematodes, and the soil chemical properties in agroforestry systems (AF), unassisted forest restoration (UFR), and natural ecosystem (Ne) located in the Brazilian Tropical and Subtropical regions. We collected soil samples to determine AMF, nematodes, soil pH, P, and soil organic carbon (SOC). AMF and nematode richness in the AF and Ne were similar in the tropical region. The redundancy analysis (RDA) indicated that the abundance of AMF and soil nema...
Source: Archives of Microbiology - September 22, 2023 Category: Microbiology Authors: Tancredo Augusto Feitosa de Souza Lucas J ónatan Rodrigues da Silva L ídia Klestadt Laurindo Gislaine Dos Santos Nascimento Milton C ésar Costa Campos Source Type: research
Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Cell Mol Immunol. 2023 Sep 22. doi: 10.1038/s41423-023-01084-z. Online ahead of print.ABSTRACTInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases. Here, we show that V-set and transmembrane domain-containing 1 (VSTM1) is an inhibitory receptor and that its binding by the competent ligand soluble galectin-1 (Gal1) is essential for maintaining neutrophil viability mediated by downregulated reactive...
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Xu Jiang Xinyue Xiao Hao Li Yiyi Gong Min Wang Huaxia Yang Lidan Zhao Ying Jiang Yanping Wei Chongchong Zhao Jin Li Yuling Chen Shan Feng Haiteng Deng Shiliang Ma Yue Xu Yudong Liu George C Tsokos Minghong Jiang Xuan Zhang Source Type: research
Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress
Cell Mol Immunol. 2023 Sep 21. doi: 10.1038/s41423-023-01082-1. Online ahead of print.NO ABSTRACTPMID:37735500 | DOI:10.1038/s41423-023-01082-1
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Shengduo Pei Jonas Sj ölund Yueyun Pan Kristian Pietras Mikael C I Karlsson Source Type: research
Plasticity of gastrointestinal vagal afferents in terms of feeding-related physiology and pathophysiology
J Physiol. 2023 Sep 22. doi: 10.1113/JP284075. Online ahead of print.ABSTRACTGastrointestinal vagal afferents play an important role in communicating food related information from the gut to the brain. This information initiates vago-vagal reflexes essential for gut functions, including gut motility and secretions. These afferents also play a role in energy homeostasis, signalling the arrival, amount and nutrient composition of a meal to the central nervous system where it is processed ultimately leading to termination of a meal. Vagal afferent responses to food related stimuli demonstrate a high degree of plasticity, resp...
Source: The Journal of Physiology - September 22, 2023 Category: Physiology Authors: Amanda J Page Source Type: research
Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column
In this study, crown ether-derived column Crownpak® CR-I (+) was evaluated under SFC conditions using 12 primary amines, and the chromatographic results were compared against eight immobilized polysaccharide-based columns. Crownpak® CR-I (+) achieved a significantly higher success rate. It was found that the addition of 5% water to the modifier dramatically improved the peak shape for chiral separation of primary amines on Crownpak® CR-I (+). The first reported preparative SFC separations on Crownpak® CR-I (+) are shown, offering a new approach for the preparative resolution of primary amines. The case studies demonstr...
Source: Chirality - September 22, 2023 Category: Molecular Biology Authors: Lei Yue Larry Miller John Reilly Source Type: research
Stieleria tagensis sp. nov., a novel member of the phylum Planctomycetota isolated from Tagus River in Portugal
Antonie Van Leeuwenhoek. 2023 Sep 22. doi: 10.1007/s10482-023-01877-2. Online ahead of print.ABSTRACTA bacterial strain was isolated from a brackish water sample of Tagus river, Alcochete, Portugal and was designated TO1_6T. It forms light pink colonies on M13 medium supplemented with N-acetylglucosamine. Cells are pear-shaped to spherical, form rosettes and divide by budding. Strain TO1_6T presents a mesophilic and neutrophilic profile, with optimum growth at 20 to 25 °C and pH 7.0 to 7.5, and vitamin supplementation is not required to promote its growth. The genome of the novel isolate is 7.77 Mbp in size and has a DNA ...
Source: Antonie van Leeuwenhoek - September 22, 2023 Category: Microbiology Authors: Of élia Godinho Dominika Klimek Adrianna Jackiewicz B árbara Guedes Eduarda Almeida Rita Calisto In ês Rosado Vitorino Jos é Diogo Neves Santos Ignacio Gonz ález Alexandre Lobo-da-Cunha Magdalena Calusinska Sandra Quinteira Olga Maria Lage Source Type: research
Identification and characterisation of a major outer membrane protein from Methylacidiphilum fumariolicum SolV
In this study, we identified and characterised a major outer membrane protein (WP_009059494) from Methylacidiphilum fumariolicum SolV. PRED-TMBB and AlphaFold2 predicted this protein to form a porin with a β-barrel structure consisting of ten antiparallel β-sheets and with a small amphipathic N-terminal α-helix in the periplasm. We purified soluble recombinant protein WP_009059494 from E. coli using Tris-HCl buffer with SDS. Antibodies were raised against two peptides in the two large extracellular loops of protein WP_009059494 and immunogold localisation showed this protein to be mainly present in the OM of strain SolV...
Source: Antonie van Leeuwenhoek - September 22, 2023 Category: Microbiology Authors: Changqing Liu Rob Mesman Arjan Pol Federica Angius Huub J M Op den Camp Source Type: research
