Galectin-9, a pro-survival factor inducing immunosuppression, leukemic cell transformation and expansion
Mol Biol Rep. 2024 Apr 25;51(1):571. doi: 10.1007/s11033-024-09563-w.ABSTRACTLeukemia is a malignancy of the bone marrow and blood originating from self-renewing cancerous immature blast cells or transformed leukocytes. Despite improvements in treatments, leukemia remains still a serious disease with poor prognosis because of disease heterogeneity, drug resistance and relapse. There is emerging evidence that differentially expression of co-signaling molecules play a critical role in tumor immune evasion. Galectin-9 (Gal-9) is one of the key proteins that leukemic cells express, secrete, and use to proliferate, self-renew, ...
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Cansu Y ıldırım Source Type: research
Mutational spectrum of CFTR in cystic fibrosis patients with gastrointestinal and hepatobiliary manifestations
CONCLUSION: The study reports novel and reported variants in the CFTR gene in CF patients in Pakistani population having distinct phenotypes. It also emphasizes screening suspected Pakistani CF patients for the p. (Met1Thr) variant because of its increased observance and prevalence in the study. Moreover, the findings also signify searching for additional pathogenic variants in the genome of CF patients, which may modify the phenotypes. The findings contribute valuable information for the diagnosis, genetic counseling, and potential therapeutic strategies for CF patients in Pakistan.PMID:38662334 | DOI:10.1007/s11033-024-0...
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Nadia Waheed Rehmana Waris Maryam Naseer Ayesha Razzaq Nighat Haider Abid Ali Shah Asmat Ullah Source Type: research
Evolutionary characteristics of the mitochondrial NADH dehydrogenase subunit 6 gene in some populations of four sympatric Mustela species (Mustelidae, Mammalia) from central Europe
CONCLUSIONS: Negative selection for MT-ND6 within the genus Mustela suggests absence of both environmental and species-specific effects of cellular energy metabolism despite large species-specific differences in body size. The presently found shared polymorphism in European polecats and steppe polecats may result from ancestral polymorphism before speciation and historical or recent introgressive hybridization; it may indicate mtDNA capture of steppe polecats by M. putorius in Europe.PMID:38664260 | DOI:10.1007/s11033-024-09505-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Ghada Tissaoui Franz Suchentrunk Asma Awadi Steve Smith Antje Weber Hichem Ben Slimen Source Type: research
Correction: Detection of SARS-CoV-2 spike protein D614G mutation using μTGGE
Mol Biol Rep. 2024 Apr 25;51(1):574. doi: 10.1007/s11033-024-09348-1.NO ABSTRACTPMID:38664266 | DOI:10.1007/s11033-024-09348-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Kevin Maafu Juma Kenta Morimoto Vishnu Sharma Kirti Sharma Radhika Biyani Manish Biyani Teisuke Takita Kiyoshi Yasukawa Source Type: research
Identification of genes related to ribosomal proteins in colorectal cancer: exploring their potential as biomarkers, prognostic indicators, and therapeutic targets
CONCLUSION: The general results of this study have shown that many genes related to RPs are increased in cancer and could be associated with the death rate of patients. We also highlighted the therapeutic and prognostic potentials of RPs genes in CRC.PMID:38664314 | DOI:10.1007/s11033-024-09522-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Negin Salehinia Aseel Kamil Mohammad Al-Mosawi Duaa Kamel Al-Moussawi Ensieh Sagheb Sadeghi Atefeh Zamani Mohammad Mahdevar Source Type: research
Diagnostic yield of the chromosomal microarray analysis in turkish patients with unexplained development delay/ ıntellectual disability(ID), autism spectrum disorders and/or multiple congenital anomalies and new clinical findings
CONCLUSIONS: In this study, chromosomal microarray analysis revealed pathogenic de novo copy number variants with new clinical features. Chromosomal microarray analysis in the Turkish population has been reported in the largest patient cohort to date.PMID:38664339 | DOI:10.1007/s11033-024-09545-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Nejmiye Akkus Pelin Ozyavuz Cubuk Source Type: research
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
High prevalence of plasmid-mediated quinolone resistance in escherichia coli strains producing extended-spectrum beta-lactamases isolated from faeces and urine of pregnant women with acute cystitis
CONCLUSION: This study revealed a high rate of resistance to the quinolone nalidixic acid and a widespread distribution of PMQR genes in MDR E. coli strains producing ESBLs. The strains represented virulence factors and phylogenetic group B2 are closely associated with abundance in UTI and faeces. However, the predominant clones in faeces were not found in UTIs and it is possible that rep-PCR is not sufficiently discriminating clones.PMID:38656625 | DOI:10.1007/s11033-024-09491-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Maryam Sohrabi Javad Fathi Samane Mohebi Zahra Hashemizadeh Soudeh Kholdi Mahtab Hadadi Kowsar Keshavarz Zahra Darvishvand Source Type: research
Conditioned medium-enriched umbilical cord mesenchymal stem cells: a potential therapeutic strategy for spinal cord injury, unveiling transcriptomic and secretomic insights
CONCLUSIONS: In conclusion, the CBG-UCNSC method effectively preserved the integrity of the transplanted neuronal-like cells and improved locomotor function. Thus, CM-enriched cells can potentially reduce biosafety risks associated with animal content, making them a promising option for clinical applications in treating spinal cord injuries.PMID:38658405 | DOI:10.1007/s11033-024-09503-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Rajasekaran Subbarayan Dinesh Murugan Girija Selvaraj Thirupathi Kumara Raja Alagudurai Krishnamoorthy Dhasarathdev Srinivasan Rupendra Shrestha Nityanand Srivastava Suresh Ranga Rao Source Type: research
Correction: Gene expression analysis of intestinal IL-8, IL-17 A and IL-10 in patients with celiac and inflammatory bowel diseases
Mol Biol Rep. 2024 Apr 24;51(1):569. doi: 10.1007/s11033-024-09440-6.NO ABSTRACTPMID:38658466 | DOI:10.1007/s11033-024-09440-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Elham Aghamohamad Nastaran Asri Aylin Odak Mohammad Rostami-Nejad Vahid Chaleshi Yasaman Hajinabi Maryam Eslami Saeed Mohammadian Haftcheshmeh Fahimeh Sadat Gholam-Mostafaei Hamid Asadzadeh-Aghdaei Andrea Masotti Mohammad Reza Zali Source Type: research
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
CONCLUSION: The induced cell death, oxidative stress and mitochondria impairment beside attenuated levels of cancer stem cell markers following BHB administration emphasize on the distinctive role of metabolic plasticity of cancer cells and propose possible therapeutic approaches to control cancer cell growth through metabolic fuels.PMID:38656394 | DOI:10.1007/s11033-024-09501-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Farzad Izak Shirian Milad Karimi Maryam Alipour Siamak Salami Mitra Nourbakhsh Samira Nekufar Nahid Safari-Alighiarloo Masoumeh Tavakoli-Yaraki Source Type: research
Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries
CONCLUSION: In case of atypical presentation of a pulmonary embolism, a tumor originating from the great vessels should be considered. Molecular pathology techniques support in establishing a reliable diagnosis.PMID:38656400 | DOI:10.1007/s11033-024-09467-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: A D örr A Fl örcken L Bullinger D Capper A Von Deimling D Kaul S M ärdian C Starck D Horst M P Dragomir F M Sch äfer A Jarosch Source Type: research
Unlocking the potential of adeno-associated virus in neuroscience: a brief review
Mol Biol Rep. 2024 Apr 22;51(1):563. doi: 10.1007/s11033-024-09521-6.ABSTRACTAdeno-associated virus (AAV) has emerged as a pivotal tool in neuroscience research, owing to its remarkable versatility and efficiency in delivering genetic material to diverse cell types within the nervous system. This mini review aims to underscore the advanced applications of AAV vectors in neuroscience and their profound potential to revolutionize our understanding of brain function and therapeutic interventions for neurological disorders. By providing a concise overview of the latest developments and strategies employing AAV vectors, this re...
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Antea Minetti Source Type: research
The ras-related protein RAB22A interacts with hypoxia-inducible factor 1-alpha (HIF-1 α) in MDA-MB-231 breast cancer cells in hypoxia
CONCLUSIONS: Our study is the first to reveal the potential involvement of HIF-1α in intracellular trafficking through physical interactions with the small GTPase protein RAB22A. We discuss the implications of our work on the role of exosomes and microvesicles in tumor invasiveness.PMID:38647725 | DOI:10.1007/s11033-024-09516-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 22, 2024 Category: Molecular Biology Authors: Nikolaos A Papanikolaou Maria Kakavoulia Christos Ladias Athanasios G Papavassiliou Source Type: research
