Hepatocellular carcinoma after direct-acting antivirals for hepatitis C is associated with KIR-HLA types predicting weak NK cell-mediated immunity
CONCLUSION: Cirrhosis is the main risk state predisposing to HCC, but weak NK-cell-mediated immunity may predispose to post-2G DAA HCC more than intermediate or strong NK-cell-mediated immunity.PMID:38700055 | DOI:10.1002/eji.202350678 (Source: European Journal of Immunology)
Source: European Journal of Immunology - May 3, 2024 Category: Allergy & Immunology Authors: James C Ryan Christina Haight Erene C Niemi Joshua D Grab Jennifer L Dodge Lewis L Lanier Alexander Monto Source Type: research
Autoantibodies against complement proteins in patients with antiphospholipid syndrome: Prevalence and clinical associations
Eur J Immunol. 2024 May 3:e2350832. doi: 10.1002/eji.202350832. Online ahead of print.ABSTRACTSeventy-seven patients with antiphospholipid syndrome were tested for autoantibodies against C1q, C3, FB, FH, and C4bp. Fifty-seven patients had at least one anti-complement antibody. IgM anti-FH positivity was associated with thrombosis when anti-C3 and anti-FB were, negatively or positively, associated with various noncriteria manifestations of antiphospholipid syndrome.PMID:38700064 | DOI:10.1002/eji.202350832 (Source: European Journal of Immunology)
Source: European Journal of Immunology - May 3, 2024 Category: Allergy & Immunology Authors: R émi Philip Achille Aouba Nicolas Martin Silva Delphine Mariotte Houcine Hamidi Sanae Rhouni Luc Darnige Marie-Agn ès Dragon-Durey Source Type: research
Regulation of B-cell function and expression of CD11c, T-bet, and FcRL5 in response to different activation signals
Eur J Immunol. 2024 May 3:e2350736. doi: 10.1002/eji.202350736. Online ahead of print.ABSTRACTCD11c, FcRL5, or T-bet are commonly expressed by B cells expanding during inflammation, where they can make up >30% of mature B cells. However, the association between the proteins and differentiation and function in the host response remains largely unclear. We have assessed the co-expression of CD11c, T-bet, and FcRL5 in an in vitro B-cell culture system to determine how stimulation via the BCR, toll-like receptor 9 (TLR9), and different cytokines influence CD11c, T-bet, and FcRL5 expression. We observed different expression ...
Source: European Journal of Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Linn Kleberg Alan-Dine Courey-Ghaouzi Maximilian Julius Lautenbach Anna F ärnert Christopher Sundling Source Type: research
IUIS 2023: yEFIS workshop on career development and code-switching
Eur J Immunol. 2024 Apr 27:e2451155. doi: 10.1002/eji.202451155. Online ahead of print.NO ABSTRACTPMID:38676471 | DOI:10.1002/eji.202451155 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Rosalie W M Kempkes Christos Nikolaou Myriam Nabhan Nathaniel Edward Bennett Saidu Source Type: research
IUIS 2023: yEFIS workshop on career development and code-switching
Eur J Immunol. 2024 Apr 27:e2451155. doi: 10.1002/eji.202451155. Online ahead of print.NO ABSTRACTPMID:38676471 | DOI:10.1002/eji.202451155 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Rosalie W M Kempkes Christos Nikolaou Myriam Nabhan Nathaniel Edward Bennett Saidu Source Type: research
IUIS 2023: yEFIS workshop on career development and code-switching
Eur J Immunol. 2024 Apr 27:e2451155. doi: 10.1002/eji.202451155. Online ahead of print.NO ABSTRACTPMID:38676471 | DOI:10.1002/eji.202451155 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Rosalie W M Kempkes Christos Nikolaou Myriam Nabhan Nathaniel Edward Bennett Saidu Source Type: research
IUIS 2023: yEFIS workshop on career development and code-switching
Eur J Immunol. 2024 Apr 27:e2451155. doi: 10.1002/eji.202451155. Online ahead of print.NO ABSTRACTPMID:38676471 | DOI:10.1002/eji.202451155 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 27, 2024 Category: Allergy & Immunology Authors: Rosalie W M Kempkes Christos Nikolaou Myriam Nabhan Nathaniel Edward Bennett Saidu Source Type: research
The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma
Eur J Immunol. 2024 Apr 23:e2350785. doi: 10.1002/eji.202350785. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/-, Il17-/-, and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concu...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Charlotte Vetter Jakob Schieb Nora Vedder Tim Lange Tobias Brunn Chiel van Geffen Philipp Gercke Saeed Kolahian Source Type: research
SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma
Eur J Immunol. 2024 Apr 23:e2350785. doi: 10.1002/eji.202350785. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/-, Il17-/-, and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concu...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Charlotte Vetter Jakob Schieb Nora Vedder Tim Lange Tobias Brunn Chiel van Geffen Philipp Gercke Saeed Kolahian Source Type: research
SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma
Eur J Immunol. 2024 Apr 23:e2350785. doi: 10.1002/eji.202350785. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/-, Il17-/-, and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concu...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Charlotte Vetter Jakob Schieb Nora Vedder Tim Lange Tobias Brunn Chiel van Geffen Philipp Gercke Saeed Kolahian Source Type: research
SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma
Eur J Immunol. 2024 Apr 23:e2350785. doi: 10.1002/eji.202350785. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/-, Il17-/-, and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concu...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Charlotte Vetter Jakob Schieb Nora Vedder Tim Lange Tobias Brunn Chiel van Geffen Philipp Gercke Saeed Kolahian Source Type: research
SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
