Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer's Disease
Curr Alzheimer Res. 2024 Apr 24. doi: 10.2174/0115672050300564240416074025. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has been considered one of the most challenging forms of dementia. The earlier the people are diagnosed with AD, the easier it is for doctors to find a treatment. Based on the previous literature summarizing the research results on the relationship between eye movement and AD before 2013, this paper reviewed 34 original eye movements research papers only closely related to AD published in the past ten years and pointed out that the prosaccade (4 papers) and antisaccade (5 papers) tasks, reading...
Source: Current Alzheimer Research - April 25, 2024 Category: Neurology Authors: Xueying He Ivan Selesnick Ming Zhu Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology
Curr Alzheimer Res. 2024 Apr 15. doi: 10.2174/0115672050301407240408033046. Online ahead of print.ABSTRACTMicrotubule-Associated Protein Tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of Alzheimer's disease (AD) pathology. Decades of research have shown that tau protein undergoes extensive post-translational modifications (PTMs), which can alter the protein's structure, function, and dynamics and impact the various properties such as solubility, aggregation, localization, and homeostasis. There is a vast amount of information describ...
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Subha Kalyaanamoorthy Stanley Kojo Opare Xiaoxiao Xu Aravindhan Ganesan Praveen P N Rao Source Type: research
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review
CONCLUSION: While findings are inconclusive, suggestions for further investigation into the relationship between anesthesia exposure and increased risk for postoperative cognitive decline are discussed, in addition to factors that may allow for greater informed disclosure of potential risks of anesthesia in older adults.PMID:38623985 | DOI:10.2174/0115672050288199240408035201 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Kathleen Angela Willoughby-Dudley Marielle L Darwin Deana B Davalos Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology
Curr Alzheimer Res. 2024 Apr 15. doi: 10.2174/0115672050301407240408033046. Online ahead of print.ABSTRACTMicrotubule-Associated Protein Tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of Alzheimer's disease (AD) pathology. Decades of research have shown that tau protein undergoes extensive post-translational modifications (PTMs), which can alter the protein's structure, function, and dynamics and impact the various properties such as solubility, aggregation, localization, and homeostasis. There is a vast amount of information describ...
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Subha Kalyaanamoorthy Stanley Kojo Opare Xiaoxiao Xu Aravindhan Ganesan Praveen P N Rao Source Type: research
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review
CONCLUSION: While findings are inconclusive, suggestions for further investigation into the relationship between anesthesia exposure and increased risk for postoperative cognitive decline are discussed, in addition to factors that may allow for greater informed disclosure of potential risks of anesthesia in older adults.PMID:38623985 | DOI:10.2174/0115672050288199240408035201 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Kathleen Angela Willoughby-Dudley Marielle L Darwin Deana B Davalos Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology
Curr Alzheimer Res. 2024 Apr 15. doi: 10.2174/0115672050301407240408033046. Online ahead of print.ABSTRACTMicrotubule-Associated Protein Tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of Alzheimer's disease (AD) pathology. Decades of research have shown that tau protein undergoes extensive post-translational modifications (PTMs), which can alter the protein's structure, function, and dynamics and impact the various properties such as solubility, aggregation, localization, and homeostasis. There is a vast amount of information describ...
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Subha Kalyaanamoorthy Stanley Kojo Opare Xiaoxiao Xu Aravindhan Ganesan Praveen P N Rao Source Type: research
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review
CONCLUSION: While findings are inconclusive, suggestions for further investigation into the relationship between anesthesia exposure and increased risk for postoperative cognitive decline are discussed, in addition to factors that may allow for greater informed disclosure of potential risks of anesthesia in older adults.PMID:38623985 | DOI:10.2174/0115672050288199240408035201 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Kathleen Angela Willoughby-Dudley Marielle L Darwin Deana B Davalos Source Type: research
Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration
In conclusion, a comprehensive understanding of the complex pathophysiology of AD and the exploration of herbal interventions offer a holistic approach to managing this devastating disease. Future research should address the limitations associated with herbal drugs and further evaluate the efficacy of promising natural products in clinical settings.PMID:38623983 | DOI:10.2174/0115672050309057240404075003 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Debasis Sen Sunny Rathee Vishal Pandey Sanjay K Jain Umesh K Patil Source Type: research
Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology
Curr Alzheimer Res. 2024 Apr 15. doi: 10.2174/0115672050301407240408033046. Online ahead of print.ABSTRACTMicrotubule-Associated Protein Tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of Alzheimer's disease (AD) pathology. Decades of research have shown that tau protein undergoes extensive post-translational modifications (PTMs), which can alter the protein's structure, function, and dynamics and impact the various properties such as solubility, aggregation, localization, and homeostasis. There is a vast amount of information describ...
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Subha Kalyaanamoorthy Stanley Kojo Opare Xiaoxiao Xu Aravindhan Ganesan Praveen P N Rao Source Type: research
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review
CONCLUSION: While findings are inconclusive, suggestions for further investigation into the relationship between anesthesia exposure and increased risk for postoperative cognitive decline are discussed, in addition to factors that may allow for greater informed disclosure of potential risks of anesthesia in older adults.PMID:38623985 | DOI:10.2174/0115672050288199240408035201 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 16, 2024 Category: Neurology Authors: Kathleen Angela Willoughby-Dudley Marielle L Darwin Deana B Davalos Source Type: research
Evaluation and Characterization of Modified K114 Method to Localize Plaques in Rodent and Plaques and Tangles in Human Brain Tissue
CONCLUSION: Our modified method can label amyloid plaques within 5 min in the rat brain and within 20 min in the human brain. Our results indicated that modified K114 could be used as a valuable tool for detecting amyloid plaques and tangles with high contrast and resolution relative to other conventional fluorescence markers.PMID:38566375 | DOI:10.2174/0115672050295561240327055835 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 3, 2024 Category: Neurology Authors: Sanjana Padala Sharay Setti James Raymick Joseph Hanig Sumit Sarkar Source Type: research
Evaluation and Characterization of Modified K114 Method to Localize Plaques in Rodent and Plaques and Tangles in Human Brain Tissue
CONCLUSION: Our modified method can label amyloid plaques within 5 min in the rat brain and within 20 min in the human brain. Our results indicated that modified K114 could be used as a valuable tool for detecting amyloid plaques and tangles with high contrast and resolution relative to other conventional fluorescence markers.PMID:38566375 | DOI:10.2174/0115672050295561240327055835 (Source: Current Alzheimer Research)
Source: Current Alzheimer Research - April 3, 2024 Category: Neurology Authors: Sanjana Padala Sharay Setti James Raymick Joseph Hanig Sumit Sarkar Source Type: research
