Clinical and Experimental Nephrology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Neferine alleviates acute kidney injury by regulating the PPAR- α/NF-κB pathway
AbstractAcute kidney injury (AKI) is a cluster of clinical syndromes with diverse etiologies that ultimately result in a swift decline in kidney function. Regrettably, AKI lacks effective therapeutic agents at present. Neferine, a bioactive alkaloid derived from Lotus Plumule, has been reported to alleviate AKI triggered by cisplatin, ischemia/reperfusion (I/R), and sepsis by inhibiting inflammatory pathways. However, the precise molecular mechanisms underpinning its renoprotective effects remain elusive. Peroxisome proliferator-activated receptor alpha (PPAR- α), a regulator of lipid metabolism with anti-inflammatory pro...
Source: Clinical and Experimental Nephrology - April 24, 2024 Category: Urology & Nephrology Source Type: research

Dialysis Duration, Time Interaction, and Visceral Fat Accumulation: A 6-Year Posttransplantation Study
ConclusionsThe study revealed that KT promoted significant alterations in body composition characterized by increase in the VAT and SAT and a decline in SMR. Notably, dialysis duration and its interaction with posttransplantation duration emerged as significant factors influencing VAT increase. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 24, 2024 Category: Urology & Nephrology Source Type: research

Trimerization profile of type IV collagen COL4A5 exon deletion in X-linked Alport syndrome
ConclusionExon skipping is advantageous for nonsense mutants in AS with severe phenotypes and early onset of renal failure but applications may be limited to ΔExons capable of normal trimerization and secretion. This study provides information on α5(IV) exon-skipping for possible therapeutic application and the prediction of the trimer behavior associated with exon-skipping in Alport syndrome. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 24, 2024 Category: Urology & Nephrology Source Type: research

Targeting ferroptosis for treating kidney disease
AbstractFerroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes that regulate ferroptosis such as GSH-GPX4 pathway and FSP1-coenzyme Q10/vitamin K pathway. From a disease perspective, the involvement of ferroptosis in pathological conditions including kidney disease has attracted attention. In terms of renal pathophysiology, ferroptosis has been widely investigated for its involvement in ischemia –reperfusion injury, nephrotoxin-induced...
Source: Clinical and Experimental Nephrology - April 22, 2024 Category: Urology & Nephrology Source Type: research

Effects of 1-week inpatient multidisciplinary care for chronic kidney disease prior to outpatient collaborative care
ConclusionEducational hospitalization prior to outpatient collaborative care is beneficial for preventing hemodialysis induction using a central venous catheter and postponing dialysis induction. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2024 Category: Urology & Nephrology Source Type: research

Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA –KIDNEY
ConclusionsEmpagliflozin safely reduced the risk of “kidney disease progression or cardiovascular death” in patients with CKD, with consistent effects in participants from Japan. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2024 Category: Urology & Nephrology Source Type: research

Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis
ConclusionsGal-3 was strongly associated with BNP, GDF-15, IVST and LVMI in patients undergoing PD treatment. Prospective studies should be carried out to determine whether Gal-3 can be a promising biomarker in predicting increased risk of adverse cardiovascular events in PD patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 20, 2024 Category: Urology & Nephrology Source Type: research

Targeting inflammation in perivascular cells and neuroimmune interactions for treating kidney disease
AbstractInflammation plays a crucial role in the pathophysiology of various kidney diseases. Kidney perivascular cells (pericytes/fibroblasts) are responsible for producing proinflammatory molecules, promoting immune cell infiltration, and enhancing inflammation. Vascular adhesion protein-1, expressed in kidney perivascular cells, is an ectoenzyme that catalyzes the oxidative deamination of primary amines with the production of hydrogen peroxide in the extracellular space. Our study demonstrated that blocking this enzyme suppressed hydrogen peroxide production and neutrophil infiltration, thereby reducing renal ischemia �...
Source: Clinical and Experimental Nephrology - April 17, 2024 Category: Urology & Nephrology Source Type: research

Renal outcome of living kidney donors aged more than 70 years
ConclusionsOlder donors tend to develop CKD stage3b within 5 years post-donation but with the potential of recovery. Healthy older people (aged ≥70 years) could be candidates for living donors under careful monitoring of kidney function after donation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 14, 2024 Category: Urology & Nephrology Source Type: research

Letermovir safety and efficacy for cytomegalovirus prophylaxis in adult Japanese kidney transplant recipients: a multicenter, open-label, noncomparative Phase 3 study
ConclusionLetermovir was generally well tolerated, and the data support its use for the prevention of CMV disease/infection in adult Japanese KTRs.Trial registrationClinicalTrials.gov NCT04129398. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 13, 2024 Category: Urology & Nephrology Source Type: research

Efficacy and safety of telitacicept in patients with lupus nephritis: a single-center, real-world retrospective study
ConclusionsTelitacicept treatment reduced disease severity in patients with LN. The initial clinical trial provided supportive evidence for the effectiveness and safety of Telitacicept as a viable treatment option for LN, allowing a reduction in the daily glucocorticoid intake while maintaining a good safety profile, and improving hypocomplementation in LN management. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 13, 2024 Category: Urology & Nephrology Source Type: research

Comparative effects of sodium –glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors on kidney function decline in Japanese individuals with type 2 diabetes
ConclusionsThis study provides potential evidence of the superiority of SGLT2is over DPP4is in slowing kidney function decline in Japanese adults with type 2 diabetes and eGFR ≥ 30 mL/min/1.73 m2. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - April 13, 2024 Category: Urology & Nephrology Source Type: research