Anti-SARS-CoV-2 IgG antibody titer after BNT162b2 mRNA COVID-19 vaccination in Japanese patients who underwent renal replacement therapy, hemodialysis, peritoneal dialysis, and kidney transplantation
ConclusionsRRT patients, particularly KT recipients, exhibited poor vaccine responses. Booster vaccination would be beneficial for HD and PD patients; however, its effect in KT recipients was mild. Further COVID-19 vaccinations using the latest vaccine or alternative procedures should be considered in RRT patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 26, 2023 Category: Urology & Nephrology Source Type: research

Assessment of metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease: a cross-sectional study
ConclusionsHypocitraturia was found to be significantly higher in patients with ADPKD than in healthy adults and other kidney stone patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 26, 2023 Category: Urology & Nephrology Source Type: research

N-methyl-2-pyridone-5-carboxamide (N-Me-2PY) has potent anti-fibrotic and anti-inflammatory activity in a fibrotic kidney model: is it an old uremic toxin?
ConclusionsNAD  + metabolites, such as N-Me-2PY, are not uremic toxins but are potential therapeutic agents that have anti-fibrotic effects in CKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 25, 2023 Category: Urology & Nephrology Source Type: research

Predictive factors of long-term disease remission after rituximab administration in patients with childhood-onset complicated steroid-dependent nephrotic syndrome: a single-center retrospective study
ConclusionFor older children with complicated SDNS, RTX appeared to be a suitable disease-modifying therapy without persistent adverse events. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 21, 2023 Category: Urology & Nephrology Source Type: research

The effect of renal replacement therapy on health-related quality of life in end-stage renal disease: a meta-analysis
ConclusionFor the treatment of ESRD, either KT, PD, or HoD can be used in terms of HRQoL. We need to improve the factors affecting the HRQoL of ESRD patients undergoing HD and ICHD. Healthcare professionals should consider the factors that influence HRQoL and choose an RTT method for each ESRD patient. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

eGFR slope as a surrogate endpoint for clinical study in early stage of chronic kidney disease: from The Japan Chronic Kidney Disease Database
ConclusionEven in Japanese patients with early stage CKD, a slower eGFR slope calculated from eGFR values over 2 –3 years was associated with a decreased risk of ESKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

Trace proteinuria detected via dipstick test is associated with kidney function decline and new-onset overt proteinuria: the Japan Specific Health Checkups (J-SHC) Study
ConclusionsTrace proteinuria (detected via dipstick test) was associated with subsequent kidney function decline and overt proteinuria in the general population. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

The effect of renal replacement therapy on health-related quality of life in end-stage renal disease: a meta-analysis
ConclusionFor the treatment of ESRD, either KT, PD, or HoD can be used in terms of HRQoL. We need to improve the factors affecting the HRQoL of ESRD patients undergoing HD and ICHD. Healthcare professionals should consider the factors that influence HRQoL and choose an RTT method for each ESRD patient. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

eGFR slope as a surrogate endpoint for clinical study in early stage of chronic kidney disease: from The Japan Chronic Kidney Disease Database
ConclusionEven in Japanese patients with early stage CKD, a slower eGFR slope calculated from eGFR values over 2 –3 years was associated with a decreased risk of ESKD. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

Trace proteinuria detected via dipstick test is associated with kidney function decline and new-onset overt proteinuria: the Japan Specific Health Checkups (J-SHC) Study
ConclusionsTrace proteinuria (detected via dipstick test) was associated with subsequent kidney function decline and overt proteinuria in the general population. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 19, 2023 Category: Urology & Nephrology Source Type: research

The differences in renal hemodynamic response following high-intensity exercise between younger and older males
ConclusionsOur findings demonstrate that RBF following high-intensity exercise recovered 60-min after exercise in younger group, whereas RBF recovery was delayed in the older group. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - July 14, 2023 Category: Urology & Nephrology Source Type: research