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Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury
ConclusionThis study demonstrated a novel mechanism by which Erbin regulates NLRP3 inflammasome-mediated pyroptosis in SI-AKI. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 13, 2023 Category: Urology & Nephrology Source Type: research

Japanese clinical practice patterns of primary nephrotic syndrome 2021: a web-based questionnaire survey of certified nephrologists
ConclusionGaps in recommendations and practices regarding serodiagnosis and treatment of MN (i.e., CQ1 and 4) are observed, suggesting the need to address the barriers to their insurance reimbursement and the lack of evidence behind them. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 13, 2023 Category: Urology & Nephrology Source Type: research

Risk factors for early dialysate leakage around the exit site after catheter placement in pediatric peritoneal dialysis: a single-center experience
ConclusionsA break-in period of > 7 days and if possible 14 days is recommended to avoid leakage in pediatric patients. Whereas infants with low body weight are at high risk of leakage, their difficulty in inserting double-cuffed catheter, hemodialysis complications, and possible leakage even under long break-in period make pre vention of leakage challenging. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 8, 2023 Category: Urology & Nephrology Source Type: research

Investigation of the current situation regarding diagnosis and treatment of Alport syndrome in Asian countries: results of survey of the Asian Paediatric Nephrology association (AsPNA) tubular and inherited working group
ConclusionsThis study result might suggest that the system is underdeveloped enough to diagnose all Alport syndrome patients in most Asian countries. However, once diagnosed with Alport syndrome, most of them were treated with RAS inhibitors. These survey results can be used to address knowledge, diagnostic system, and treatment strategy gaps and improve the Alport patients ’ outcomes in Asian countries. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 8, 2023 Category: Urology & Nephrology Source Type: research

Higher hemoglobin levels using darbepoetin alfa and kidney outcomes in advanced chronic kidney disease without diabetes: a prespecified secondary analysis of the PREDICT trial
ConclusionsIn the per-protocol set, the high-hemoglobin group demonstrated better kidney outcomes than the low-hemoglobin group, suggesting a potential benefit of maintaining higher hemoglobin levels in patients with advanced CKD without diabetes.Clinical trial registrationClinicaltrials.gov (identifier: NCT01581073). (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 8, 2023 Category: Urology & Nephrology Source Type: research

Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan
AbstractEncapsulating peritoneal sclerosis (EPS), a condition with a high mortality rate, is a serious complication of peritoneal dialysis (PD). In Japan, EPS became a central issue in the clinical setting during the mid-90s and the beginning of this century. However, following the introduction of biocompatible neutral PD solutions containing lower levels of glucose degradation products, the incidence and clinical severity of EPS has been greatly lessened. During the past three decades, the etiology of EPS has been elucidated by findings obtained by peritoneal biopsy, laparoscopy, and surgical intervention. Accumulating fi...
Source: Clinical and Experimental Nephrology - June 6, 2023 Category: Urology & Nephrology Source Type: research

Relationship between serum sodium level at dialysis initiation and all-cause mortality
ConclusionHyponatremia of < 130 mEq/L at dialysis initiation was significantly associated with all-cause mortality. We considered the results relevant to underlying conditions, including cardiovascular disease and medications. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - June 2, 2023 Category: Urology & Nephrology Source Type: research