A nationwide survey of MYH9-related disease in Japan
ConclusionOur study demonstrated no beneficial effect of RAS inhibitors on kidney function in patients withMYH9-RD, indicating the need for further studies with more patients. All modalities of KRT are feasible options forMYH9-RD patients who progress to ESKD, with adequate attention to bleeding complications. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 21, 2023 Category: Urology & Nephrology Source Type: research

Evaluating the understandability and actionability of online CKD educational materials
ConclusionMedical institutions and academic organizations are encouraged to use plain language and to attach explanations of medical terms when preparing materials for patients. They are also expected to improve visual aids to promote healthy behaviors. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 16, 2023 Category: Urology & Nephrology Source Type: research

Renal outcomes in IgA nephropathy following inactivated SARS-CoV-2 vaccination
ConclusionKidney function in IgAN patients tended to worsen after SARS-CoV-2 vaccination, particularly those with initial poor kidney function. This pattern of disease flare appears to be clinically mild, and further research is needed to determine whether the impact on kidney function is long-term. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 15, 2023 Category: Urology & Nephrology Source Type: research

External validation of the pediatric International IgA Nephropathy Prediction Tool in a central China cohort
ConclusionThe model without race could accurately distinguish the highest-risk patients from patients with low, intermediate, and high risk for kidney progression. Discrimination and calibration for the full model with or without race were unsatisfactory in this contemporary cohort in central China. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 15, 2023 Category: Urology & Nephrology Source Type: research

Renal outcomes in IgA nephropathy following inactivated SARS-CoV-2 vaccination
ConclusionKidney function in IgAN patients tended to worsen after SARS-CoV-2 vaccination, particularly those with initial poor kidney function. This pattern of disease flare appears to be clinically mild, and further research is needed to determine whether the impact on kidney function is long-term. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 15, 2023 Category: Urology & Nephrology Source Type: research

External validation of the pediatric International IgA Nephropathy Prediction Tool in a central China cohort
ConclusionThe model without race could accurately distinguish the highest-risk patients from patients with low, intermediate, and high risk for kidney progression. Discrimination and calibration for the full model with or without race were unsatisfactory in this contemporary cohort in central China. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 15, 2023 Category: Urology & Nephrology Source Type: research

Reference values for urinary protein, albumin, beta 2-microglobulin, and the alpha 1-microglobulin-to-creatinine ratio in Japanese children
ConclusionThe present study was the first to determine appropriate reference values for the PCR, ACR, BMCR, and AMCR based on an analysis of the first morning urine samples of a large number of children. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 7, 2023 Category: Urology & Nephrology Source Type: research

The association of serum anti-PLA2R antibody and glomerular  PLA2R antigen staining with clinical manifestations and outcomes in membranous nephropathy
ConclusionsOur study showed that the clinical manifestations of SAb  + /Gag− patients were the same as those of double-positive patients, while SAb−/GAg + patients exhibited mild clinical manifestations and slower eGFR decline compared to the double-positive patients. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 5, 2023 Category: Urology & Nephrology Source Type: research

Association between inpatient education program for patients with pre-dialysis chronic kidney disease and new-onset cardiovascular disease after initiating dialysis
ConclusionIEPs were associated with a lower rate of new-onset CVD after initiating dialysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 1, 2023 Category: Urology & Nephrology Source Type: research

Urinary cell cycle biomarkers for the prediction of renal non-recovery in patients with septic acute kidney injury: a prospective study
ConclusionsThe combination of urinary [TIMP-2]*[IGFBP7] at 0  h exhibited moderate predictive ability for renal non-recovery in cases of septic AKI. However, there is potential to enhance the prognostic capabilities of the [TIMP-2]*[IGFBP7]–clinical prediction model. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 1, 2023 Category: Urology & Nephrology Source Type: research

Association between inpatient education program for patients with pre-dialysis chronic kidney disease and new-onset cardiovascular disease after initiating dialysis
ConclusionIEPs were associated with a lower rate of new-onset CVD after initiating dialysis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - September 1, 2023 Category: Urology & Nephrology Source Type: research