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Nutrition: Calcium
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Rapid degradation and detoxification of metronidazole using calcium sulfite activated by CoCu two-dimensional layered bimetallic hydroxides: Performance, mechanism, and degradation pathway
In this study, cobalt copper-layered double hydroxides (CoCu-LDHs) were prepared by coprecipitation as catalysts to activate CaSO3 for metronidazole (MNZ) degradation. This is the first report on layered double hydroxides activating sulfite for the degradation of organic pollutants. Meanwhile, to address the issue of self-quenching reactions readily occurring in conventional sulfite advanced oxidation systems and resulting in low oxidant efficiency, CaSO3 with slightly soluble in water was used instead of commonly used Na2SO3, to improve the limitations of traditional systems. The results showed that in the CoCu-LDHs/CaSO3...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Xiaoyan Lu Kai Wang Dedong Wu Pengfei Xiao Source Type: research
Protective effect of dietary micronutrients on gastric cancer risk among Jordanians
CONCLUSIONS: our data support favorable effects of dietary consumption of some vitamins and minerals against GC risk.PMID:37705441 | DOI:10.20960/nh.04547
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Sabika Allehdan Shatha S Hammad Razan M Alatrash Tareq Al-Jaberi Ahmad Hushki Shirin Yacoub Mohammad Dahoud Tahra Elobeid Reema Tayyem Tayyem Source Type: research
Rapid degradation and detoxification of metronidazole using calcium sulfite activated by CoCu two-dimensional layered bimetallic hydroxides: Performance, mechanism, and degradation pathway
In this study, cobalt copper-layered double hydroxides (CoCu-LDHs) were prepared by coprecipitation as catalysts to activate CaSO3 for metronidazole (MNZ) degradation. This is the first report on layered double hydroxides activating sulfite for the degradation of organic pollutants. Meanwhile, to address the issue of self-quenching reactions readily occurring in conventional sulfite advanced oxidation systems and resulting in low oxidant efficiency, CaSO3 with slightly soluble in water was used instead of commonly used Na2SO3, to improve the limitations of traditional systems. The results showed that in the CoCu-LDHs/CaSO3...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Xiaoyan Lu Kai Wang Dedong Wu Pengfei Xiao Source Type: research
3D interconnected porous PMMA scaffold integrating with advanced nanostructured CaP-based biomaterials for rapid bone repair and regeneration
J Mech Behav Biomed Mater. 2023 Sep 7;147:106106. doi: 10.1016/j.jmbbm.2023.106106. Online ahead of print.ABSTRACTBioactive scaffolds with polymer and nanostructured bioactive glass-based composites are promising materials for regenerative applications in consequence of close mimics of natural bone composition. Poly methyl methacrylate (PMMA) is a highly preferred thermoplastic polymer for orthopedic applications as it has good biocompatibility. Different kinds of bioactive, biodegradable as well as biocompatible biomaterial composites such as Bioglass (BG), Hydroxyapatite (Hap), and Tricalcium phosphate (TCP) can be integ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 14, 2023 Category: Materials Science Authors: K Elakkiya P Bargavi S Balakumar Source Type: research
Carboxymethyl chitosan/polyvinyl alcohol double network hydrogels prepared by freeze-thawing and calcium chloride cross-linking for efficient dye adsorption
This study introduced a double network hydrogel, with varying carboxymethyl chitosan (CMCS) contents and polyvinyl alcohol (PVA), employing a combination of freeze- thawing and calcium chloride cross-linking. The investigation focused on the rheological properties of the hydrogels and their removal ability of acidic blue 93 (AB). The results showed that the strength and viscoelastic modulus of composite hydrogels were positively correlated with the CMCS content, and all composite hydrogels exhibited the typical weak strain overshoot behavior. The pore size of the gel initially decreased and then increased, with the densest...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Kai-Yan Zhang Dong Li Yong Wang Li-Jun Wang Source Type: research
Protective effect of dietary micronutrients on gastric cancer risk among Jordanians
CONCLUSIONS: our data support favorable effects of dietary consumption of some vitamins and minerals against GC risk.PMID:37705441 | DOI:10.20960/nh.04547
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Sabika Allehdan Shatha S Hammad Razan M Alatrash Tareq Al-Jaberi Ahmad Hushki Shirin Yacoub Mohammad Dahoud Tahra Elobeid Reema Tayyem Tayyem Source Type: research
Palladium-based multifunctional nanoparticles for combined chemodynamic/photothermal and calcium overload therapy of tumors
In this study, calcium carbonate-modified palladium hydride nanoparticles (PdH@CaCO3) were prepared and utilized for the combined treatment of tumors through chemodynamic therapy (CDT)/photothermal therapy (PTT) and calcium overload therapy. After entering tumor cells, PdH@CaCO3 releases calcium ions (Ca2+) and PdH once it reaches the TME due to the pH reactivity of the calcium carbonate coating. The mitochondrial membrane potential is lowered by the Ca2+, leading to irreversible cell damage. Meanwhile, PdH reacts with excessive hydrogen peroxide (H2O2) in the TME via the Fenton reaction, generating hydroxyl radicals (·OH...
Source: Colloids and Surfaces - September 14, 2023 Category: Biotechnology Authors: Wenge Zhang Jiangyong Li Lamei Chen Huan Chen Liangke Zhang Source Type: research
Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
CONCLUSIONS: Our study reveals that USP19 elevates the intracellular Ca2+ concentration to alter ER stress via regulation of BAG6 and BCL2 stability and may be a viable therapeutic target for TNBC therapy.PMID:37700495 | DOI:10.1002/ctm2.1398
Source: Clinical Breast Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Xiaoqiang Zhang Xuyu Chen Fangze Qian Yanhui Zhu Gao He Junzhe Yang Xian Wu Hongfei Zhang Xiafei Yu Xiaoan Liu Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF- β1 signaling pathway
J Clin Biochem Nutr. 2023 Sep;73(2):116-123. doi: 10.3164/jcbn.22-100. Epub 2023 Jul 5.ABSTRACTA widespread degenerative condition of the aorta, abdominal aortic aneurysm (AAA), severely endangers the health of middle-aged and elderly people. SPARC related modular calcium binding2 (SMOC2) is upregulated in the carotid arteries of rats with atherosclerotic lesions, but its function in AAA is still unknown. Therefore, the aim of this research was to evaluate the function of SMOC2 in AAA. The results showed that in the AAA tissues, SMOC2 expression was upregulated compared with healthy controls. Overexpression of SMOC2 promot...
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Xiaowei Wang Meng Wang Zhongxiao Zhou Xin Zou Guoxin Song Qingsong Zhang Haimeng Zhou Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
An electrokinetic-biocementation study for clay stabilisation using carbonic anhydrase-producing bacteria
This study investigates the feasibility of biocementing clay soil underneath a railway embankment of the UK rail network via carbonic anhydrase (CA) biocementation, implementing the treatments electrokinetically. Compared to previous biocementation studies using the ureolytic route, the CA pathway is attractive as CA-producing bacteria can sequester CO2 to produce biocement. Clay soil samples were treated electrokinetically using biostimulation and bioaugmentation conditions to induce biocementation. The effects of the treatment were assessed in terms of undrained shear strength using the cone penetration test, moisture co...
Source: Environmental Science and Pollution Research International - September 13, 2023 Category: Environmental Health Authors: Wilson Mwandira Maria Mavroulidou Anjali Satheesh Michael John Gunn Christopher Gray Diane Purchase Jonathan Garelick Source Type: research
