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Condition: Obesity
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Total 71604 results found since Jan 2013.
Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows
Atherosclerosis. 2023 Sep 19:117272. doi: 10.1016/j.atherosclerosis.2023.117272. Online ahead of print.ABSTRACTA steady rise in cardiovascular morbidity and mortality has been observed in young adults within the last decades. This trend corresponds to an increasing prevalence of traditional cardiovascular risk factors such as obesity and diabetes mellitus type 2 among young adults living in developed countries. Moreover, age-specific risk factors, such as substance abuse, contraceptive medication, and pregnancy-related diseases also correlate with an increased incidence of cardiovascular diseases. In this review, we discus...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Christina Antza Antonio Gallo Chrysoula Boutari Alexandra Ershova Kadri Murat Gurses Joanna Lewek Mirakhmadjon Mirmaksudov G ünther Silbernagel Joakim Sandstedt Anna Lebedeva Source Type: research
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK
Am J Physiol Endocrinol Metab. 2023 Sep 21. doi: 10.1152/ajpendo.00092.2023. Online ahead of print.ABSTRACTHyperuricemia (HUA) is strongly associated with the increasing prevalence of obesity, but the underlying mechanism remains elusive. Dysfunction of brown adipose tissue (BAT) could lead to obesity. However, studies on the role of HUA on BAT are lacking. Our retrospective clinical analysis showed that serum uric acid (UA) is significantly associated with BAT in humans. To investigate the role of UA in regulating BAT function, we used UA to treat primary brown adipocytes (BAC) in vitro and established HUA mice. In vitro ...
Source: Am J Physiol Endocri... - September 21, 2023 Category: Endocrinology Authors: Meijuan Dong Kun An Li Mao Source Type: research
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research
Prevalence and risk factors of stroke in high-altitude areas: a systematic review and meta-analysis
Conclusions
The findings of this study provide insights into the pooled prevalence of stroke in high-altitude areas, highlighting variations based on geographic regions and sampling type. Moreover, age, gender, hypertension and obesity were found to be associated with the occurrence of stroke.
PROSPERO registration number
CRD42022381541.
Source: BMJ Open - September 21, 2023 Category: General Medicine Authors: Zheng, B., Luo, Y., Li, Y., Gu, G., Jiang, J., Chen, C., Chen, Z., Wang, J. Tags: Open access, Neurology Source Type: research
Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity
This study compared high-intensity interval training (HIIT) with more conventional moderate-intensity continuous training (MICT) on intramyocellular lipid content, as well as LD characteristics (size and number) and abundance within the intramyofibrillar (IMF) and subsarcolemmal (SS) regions of type I and type II skeletal muscle fibers in adults with obesity. Thirty-six adults with obesity (BMI=33±3 kg/m2) completed 12 weeks (4d/week) of either HIIT (10x1 min, 90% HRmax + 1 min active recovery; n=19) or MICT (45 min steady-state exercise, 70% HRmax; n=17), while on a weight-maintaining diet throughout training. Skeletal m...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Michael W Schleh Cheehoon Ahn Benjamin J Ryan Olivia K Chugh Austin T Luker Kathryn E Luker Jenna B Gillen Alison C Ludzki Douglas W Van Pelt Lisa M Pitchford Tao Zhang Thomas Rode Suzette M Howton Charles F Burant Jeffrey F Horowitz Source Type: research
The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1
Sci Adv. 2023 Sep 22;9(38):eadh0980. doi: 10.1126/sciadv.adh0980. Epub 2023 Sep 20.ABSTRACTIncreasing the therapeutic potential and reducing the side effects of U.S. Food and Drug Administration-approved glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat obesity require complete characterization of the central mechanisms that mediate both the food intake-suppressive and illness-like effects of GLP-1R signaling. Our studies, in the rat, demonstrate that GLP-1Rs in the locus coeruleus (LC) are pharmacologically and physiologically relevant for food intake control. Furthermore, agonism of LC GLP-1Rs induces illn...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Samantha M Fortin Jack C Chen Marisa C Petticord Forrest J Ragozzino James H Peters Matthew R Hayes Source Type: research
Letter to the Editor. Preoperative obesity and surgery for lumbar spondylolisthesis
J Neurosurg Spine. 2023 Aug 11:1. doi: 10.3171/2023.5.SPINE23521. Online ahead of print.NO ABSTRACTPMID:37728386 | DOI:10.3171/2023.5.SPINE23521
Source: Journal of Neurosurgery.Spine - September 20, 2023 Category: Neurosurgery Authors: Peter D Angevine Source Type: research
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
CONCLUSION: The intellectual disability of moderate type (MID) was associated with abnormal changes in the levels of essential mineral elements and adipokines and increased levels of cellular oxidative stress. Thus, evaluating plasma mineral elements and adipokines levels could be a potential diagnostic parameter for diagnosing MID.PMID:37730529 | DOI:10.1186/s12860-023-00490-5
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Ahmad H Alghadir Sami A Gabr Amir Iqbal Source Type: research
Novel homozygous leptin receptor mutation in an infant with monogenic obesity
We report the case of a 12-month-old male infant born of a non-consanguineous marriage. He presented to us with rapid weight gain from 2 months of age along with hyperphagia. Biochemistry revealed a deranged lipid profile, elevated transaminases, and markedly raised serum leptin levels. On genetic analysis, a novel mutation was detected, which was a homozygous variation In exon 12 of the LEPR gene (chr1:g.65608901G>A) that resulted in the synonymous amino acid change of lysine at codon 584 proximal to donor splice site (p.Lys584). The in silico prediction of the variant was 'damaging' by MutationTaster2. The mutation wa...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Hiya Boro Vikash Bundela Velmurugan Mannar Lakshmi Nagendra Vinita Jain Bimal Jain Senthil Kumar Sourabh Agstam Source Type: research
"The obesity pandemic" in the COVID-19 pandemic - new treatment for an old problem
This article provides a review of the literature on the recent worsening of obesity in the paediatric population, with particular emphasis on the importance of the COVID-19 pandemic. New methods of fighting obesity with the use of telemedicine and current methods of pharmacotherapy, including new drugs, are presented.PMID:37728462 | DOI:10.5114/pedm.2023.129342
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Kalina Fabin-Czepiel Karolina Pieczy ńska-Chapuła Gra żyna Deja Source Type: research
Lipid metabolism and renal function markers in obese adolescents
CONCLUSIONS: Renal function of the obese adolescents included in the study was normal and the associations with lipid metabolism were poorly expressed.PMID:37728460 | DOI:10.5114/pedm.2023.125612
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Aleksandra Radosz Anna Obuchowicz Source Type: research
The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity
CONCLUSIONS: Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.PMID:37728459 | DOI:10.5114/pedm.2023.127273
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: Agnieszka Kozio ł-Kozakowska Ma łgorzata Wójcik Dominika Janu ś Jerzy Starzyk Source Type: research
Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity
CONCLUSION: MAFLD and other metabolic disorders in pediatric patients with obesity are associated with an elevation of adipose tissue macrophage-related inflammation markers.PMID:37729736 | DOI:10.1016/j.cyto.2023.156372
Source: Cytokine - September 20, 2023 Category: Molecular Biology Authors: Julia Lischka Andrea Schanzer Charlotte de Gier Susanne Greber-Platzer Maximilian Zeyda Source Type: research
Are 24-hour movement recommendations associated with obesity-related indicators in the young population? A meta-analysis
CONCLUSIONS: Meeting all 24-hour movement recommendations may be a crucial factor in maintaining a healthy weight status in the young population.PMID:37726964 | DOI:10.1002/oby.23848
Source: Obesity - September 20, 2023 Category: Eating Disorders & Weight Management Authors: Jos é Francisco López-Gil Miguel Angel Tapia-Serrano Javier Sevil-Serrano Pedro Antonio S ánchez-Miguel Antonio Garc ía-Hermoso Source Type: research
