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Three separate acquisitions of blaNDM-1 in three different bacterial species from a single patient
AbstractTo investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa,Acinetobacter baumannii; Ab andProteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected;blaVIM-1 (Pa; ST773),blaOXA-23 (Ab, ST499) andblaNDM-1 identified in all isolates. NDM regions were found chromosomally integrated in all i...
Source: European Journal of Clinical Microbiology and Infectious Diseases - September 9, 2023 Category: Microbiology Source Type: research
Shotgun-metagenomics reveals a highly diverse and communal microbial network present in the drains of three beef-processing plants
ConclusionThis study provides a framework for understanding the collective microbial network spanning a beef processing system. The results can be used to develop intervention strategies to best control these highly communicative microbial networks.
Source: Frontiers in cellular and infection microbiology - September 8, 2023 Category: Microbiology Source Type: research
CRISPR-Equipped Bacteria Detect Tumors
Researchers at the University of California San Diego have created a bacterial sentinel system that can alert clinicians to the presence of tumors. The technology takes advantage of the specificity of the CRISPR system and the tendency of bacteria to...
Source: Medgadget - September 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Genetics Oncology UCSD Source Type: blogs
Phenotypic, genotypic, and metabolic resistance mechanisms of ESKAPE bacteria to chemical disinfectants: a systematic review and meta-analysis
CONCLUSION: We systematically reviewed the effect of various mechanisms in the resistance process of ESKAPE bacteria to ChDs. However, except for the impact of genes, the numbers of studies investigating other mechanisms were very limited, demanding carrying out more studies in this field.PMID:37674347 | DOI:10.1080/14787210.2023.2256975
Source: Expert Review of Anti-Infective Therapy - September 7, 2023 Category: Infectious Diseases Authors: Roya Chegene Lorestani Ali Shojaeian Mosayeb Rostamian Source Type: research
Resistome-based surveillance identifies ESKAPE pathogens as the predominant gram-negative organisms circulating in veterinary hospitals
ConclusionWe describe the widespread occurrence of ESKAPE gram-negative organisms in veterinary ICU patients and hospital environments. Findings from this project provide baseline data on the epidemiology of ESKAPE pathogens in veterinary settings, which can inform infection control policies to aid in patient management and prevent transmission of nosocomial infections associated with these pathogens.
Source: Frontiers in Microbiology - September 7, 2023 Category: Microbiology Source Type: research
BamA-targeted antimicrobial peptide design for enhanced efficacy and reduced toxicity
This study employed computational simulation methods to screen and design AMPs specifically targeting ESKAPE pathogens. Particularly, AMPs were rationally designed to target the BamA and obtain novel antimicrobial peptide sequences. The designed AMPs were assessed for their antibacterial activities, mechanisms, and stability. Molecular docking and dynamics simulations demonstrated the interaction of both designed AMPs, 11pep and D-11pep, with the β1, β9, β15, and β16 chains of BamA, resulting in misfolding of outer membrane proteins and antibacterial effects. Subsequent antibacterial investigations confirmed the broad-...
Source: Amino Acids - September 5, 2023 Category: Biochemistry Authors: Li Yang Minghe Luo Zhou Liu Yuepeng Li Zhihua Lin Shan Geng Yuanqiang Wang Source Type: research
Isolation, structure elucidation, and biological activities of sesquiterpenes and phthalides from two edible mushrooms Pleurotus species
Biosci Biotechnol Biochem. 2023 Sep 4:zbad126. doi: 10.1093/bbb/zbad126. Online ahead of print.ABSTRACTAntimicrobial compounds were purified from culture filtrates from two edible Pleurotus species. Using a bioassay-guided fractionation of the culture filtrate extracts, three compounds (1-3) were obtained from Pleurotus ostreatus, and another compound (4) was obtained from Pleurotus pulmonarius. Spectroscopic analysis revealed that 1-3 was identified as 5,7-dimethoxyphthalide, 4,6-dimethoxyphthalide, and cheimonophyllon E, respectively, while 4 were identified as pleuroton A. The minimum inhibitory concentration and minimu...
Source: Bioscience, Biotechnology, and Biochemistry - September 5, 2023 Category: Biochemistry Authors: Jewel C De Padua Emi Fukushima-Sakuno Kotomi Ueno Thomas Edison E Dela Cruz Atsushi Ishihara Source Type: research
BamA-targeted antimicrobial peptide design for enhanced efficacy and reduced toxicity
This study employed computational simulation methods to screen and design AMPs specifically targeting ESKAPE pathogens. Particularly, AMPs were rationally designed to target the BamA and obtain novel antimicrobial peptide sequences. The designed AMPs were assessed for their antibacterial activities, mechanisms, and stability. Molecular docking and dynamics simulations demonstrated the interaction of both designed AMPs, 11pep and D-11pep, with the β1, β9, β15, and β16 chains of BamA, resulting in misfolding of outer membrane proteins and antibacterial effects. Subsequent antibacterial investigations confirmed the broad-...
Source: Amino Acids - September 5, 2023 Category: Biochemistry Authors: Li Yang Minghe Luo Zhou Liu Yuepeng Li Zhihua Lin Shan Geng Yuanqiang Wang Source Type: research
Molecules, Vol. 28, Pages 6431: Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using Perilla frutescens Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.
Source: Molecules - September 4, 2023 Category: Chemistry Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Tags: Article Source Type: research
Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods
In this study, we isolated and determined the biological features of a lyticA. baumannii phage called vB_AbaAut_ChT04 (vChT04). The vChT04 phage was classified as a member of the familyAutographiviridae of the classCaudoviricetes. It showed a short latent period (10 min) and a large burst size (280 PFU cell−1), and it was able to infect 52 out of 150 clinical MDR-AB strains tested (34.67%). Most of the phage-sensitive strains wereA. baumannii strains that had been isolated during the same year that the phage was isolated. The phage showed activity across a broad pH (pH 5.0 –8.0) and temperature (4–37°C) range. Whole...
Source: Archives of Virology - September 3, 2023 Category: Virology Source Type: research
