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Cancer: Brain Cancers
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Total 19412 results found since Jan 2013.
Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O < sup > 6 < /sup > -methylguanine-DNA methyltransferase gene in glioblastoma
CONCLUSION: This study provides novel mechanisms to understand methylation in GBM and identifies some biomarkers for the prognosis of two different GBM types, MGMT promoter unmethylated or methylated GBM, by using metabolomics and proteomics analyses.PMID:37641495 | DOI:10.1111/cns.14415
Source: CNS Neuroscience and Therapeutics - August 29, 2023 Category: Neuroscience Authors: Xi Chen Jinli Sun Yukui Li Weichao Jiang Zhangyu Li Jianyao Mao Liwei Zhou Sifang Chen Guowei Tan Source Type: research
Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway
Exp Brain Res. 2023 Aug 29. doi: 10.1007/s00221-023-06693-8. Online ahead of print.ABSTRACTGlioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through t...
Source: Experimental Brain Research - August 29, 2023 Category: Neuroscience Authors: Guozheng Zhao Zhitong Deng Xuetao Li Hao Wang Guangliang Chen Ming Feng Youxin Zhou Source Type: research
Biomarkers and their combination in a prediction of decompensation after an index hospitalization for acute heart failure
CONCLUSION: BNP, cystatin C, and CA125 are predictors of decompensation, and their combined usage leads to better prediction of new decompensation.PMID:37636186 | PMC:PMC10451570 | DOI:10.4103/jfmpc.jfmpc_1456_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Azra Durak-Nalbantic Edin Begic Alden Begic Alen Dzubur Orhan Lepara Rusmir Baljic Aida Hamzic-Mehmedbasic Damir Rebic Enisa Hodzic Mirza Halimic Almir Badnjevic Source Type: research
Modeling Gamma Knife Radiosurgical Toxicity for Multiple Brain Metastases
CONCLUSION: Surface area was the most accurate univariate predictor of V12 for metastatic lesions. We developed a preplan model for brain metastases that can help better estimate radionecrosis risk, determine prescription doses given a target V12, and provide safe dose escalation strategies without the use of any planning software.PMID:37640162 | DOI:10.1016/j.radonc.2023.109874
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 28, 2023 Category: Radiology Authors: Eric J Hsu Yulong Yan Robert D Timmerman Zabi Wardak Tu D Dan Toral R Patel Dat T Vo Strahinja Stojadinovic Source Type: research
Assessment and tailored physical rehabilitation approaches in persons with cerebellar impairments targeting mobility and walking according to the International Classification of Functioning: a systematic review of case-reports and case-series
CONCLUSIONS: A comprehensive test battery to encompass the key features of a PwCI on different levels of the ICF is needed to manage heterogeneity. Measures on body function level should be included in interventions.PMID:37639546 | DOI:10.1080/09638288.2023.2248886
Source: Disability and Rehabilitation - August 28, 2023 Category: Rehabilitation Authors: Anne Bogaert Francesco Roman ò Pierre Cabaraux Peter Feys Lousin Moumdjian Source Type: research
Effects of mitragynine on viability, proliferation, and migration of C6 rat glioma, SH-SY5Y human neuroblastoma, and HT22 immortalized mouse hippocampal neuron cell lines
This study aimed to investigate the antitumor effects of MG in C6 rat glioma and SH-SY5Y human neuroblastoma tumor cell lines compared with those in the non-tumor HT22 mouse hippocampal neuronal cell line. MTT assay for cell viability, clonogenic and wound healing assays for cell migration, Hoechst 33342/propidium iodide staining for nuclear morphology, and cell cycle distribution using flow cytometry were performed. MG at 125.47 μM (50 μg/ml) significantly reduced the viability of all cell lines, and the clonogenicity of C6 glioma cells began decreasing at 75.28 μM (30 μg/ml) of MG. Cell migration was inhibited in C6 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 28, 2023 Category: Drugs & Pharmacology Authors: Kittikun Viwatpinyo Sujira Mukda Sakan Warinhomhoun Source Type: research
Modeling Gamma Knife Radiosurgical Toxicity for Multiple Brain Metastases
CONCLUSION: Surface area was the most accurate univariate predictor of V12 for metastatic lesions. We developed a preplan model for brain metastases that can help better estimate radionecrosis risk, determine prescription doses given a target V12, and provide safe dose escalation strategies without the use of any planning software.PMID:37640162 | DOI:10.1016/j.radonc.2023.109874
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 28, 2023 Category: Radiology Authors: Eric J Hsu Yulong Yan Robert D Timmerman Zabi Wardak Tu D Dan Toral R Patel Dat T Vo Strahinja Stojadinovic Source Type: research
Spectral flow cytometry identifies distinct nonneoplastic plasma extracellular vesicle phenotype in glioblastoma patients
CONCLUSIONS: Multiparametric analysis demonstrates that GBM patients have a distinct nonneoplastic plasma EV phenotype compared to ND. This simple rapid analysis can be performed without purifying tumor EVs and may serve as the basis of a liquid biopsy.PMID:37638345 | PMC:PMC10457026 | DOI:10.1093/noajnl/vdad082
Source: Adv Data - August 28, 2023 Category: Epidemiology Authors: Abudumijiti Zack Aibaidula Cori E Fain Luz Cumba Garcia Annelise Wier Samantha M Bouchal Megan M Bauman Mi-Yeon Jung Jann N Sarkaria Aaron J Johnson Ian F Parney Source Type: research
Biomarkers and their combination in a prediction of decompensation after an index hospitalization for acute heart failure
CONCLUSION: BNP, cystatin C, and CA125 are predictors of decompensation, and their combined usage leads to better prediction of new decompensation.PMID:37636186 | PMC:PMC10451570 | DOI:10.4103/jfmpc.jfmpc_1456_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Azra Durak-Nalbantic Edin Begic Alden Begic Alen Dzubur Orhan Lepara Rusmir Baljic Aida Hamzic-Mehmedbasic Damir Rebic Enisa Hodzic Mirza Halimic Almir Badnjevic Source Type: research
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants in...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bevacizumab plus erlotinib versus erlotinib alone for advanced EGFR-mutant non-small cell lung cancer: a meta-analysis of randomized clinical trials
CONCLUSIONS: Combination of bevacizumab and erlotinib can prolong progression-free survival but not overall survival compared to erlotinib alone in advanced EGFR-mutant non-small cell lung cancer patients. The combination therapy not only can prolong progression-free survival but also has a tendency to prolong overall survival for patients with brain metastasis at baseline.PMID:37635242 | DOI:10.1186/s40001-023-01272-7
Source: Cell Research - August 27, 2023 Category: Cytology Authors: Ruijian Li Weiyi Li Fang Zhang Shanshan Li Source Type: research
