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Total 19412 results found since Jan 2013.
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors
We examined the hippocampal inflammation-related gene expression changes over time. The expression of interleukin-1β (Il1b) and tumor necrosis factor α (Tnfa) was rapidly enhanced and sustained until 24 h after LPS administration, whereas the expression of Il6 was transiently induced at approx. 6 h. IL-6-dependent downstream signaling of transducer and activator of transcription 3 (STAT3) was also activated approx. 3-6 h after LPS treatment. The expression of innate immune genes including interferon-induced transmembrane proteins such as interferon-induced transmembrane protein 1 (Ifitm1) and Ifitm3 and complement factor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Sumire Matsuura Yuki Nishimoto Akane Endo Hirono Shiraki Kanzo Suzuki Eri Segi-Nishida Source Type: research
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Targeted therapies for glioblastoma treatment
J Physiol Pharmacol. 2023 Jun;74(3). doi: 10.26402/jpp.2023.3.01. Epub 2023 Aug 30.ABSTRACTGlioblastoma, the most common and aggressive type of brain tumor in adults, poses significant challenges in terms of treatment. Conventional approaches including surgery, chemotherapy, and radiotherapy have yielded limited success, with a median survival of approximately 15 months. However, extensive research into the biology of glioblastoma has identified molecular targets that can be exploited by newly developed drugs, leading to the emergence of precise personalized therapies. Several innovative treatment strategies are currently ...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: A Smolarska I Pruszynska W Wasylko K Godlewska M Markowska A Rybak J Botther P Kucharzewska J Nowakowska J Szeliga M Kubiak M Gorczak M Krol Source Type: research
Naringin modulates microglial polarization through the PPAR- γ/NF-κB signaling pathway to promote functional recovery following spinal cord injury
CONCLUSION: Nar promotes functional recovery by regulating microglial polarization and inhibiting the inflammatory response in SCI, and its mechanism may be related to the PPAR-γ/NF-κB signaling pathway activity.PMID:37661010 | DOI:10.1016/j.brainres.2023.148563
Source: Brain Research - September 3, 2023 Category: Neurology Authors: Bo Li Xi-Fan Mei Source Type: research
Targeted therapies for glioblastoma treatment
J Physiol Pharmacol. 2023 Jun;74(3). doi: 10.26402/jpp.2023.3.01. Epub 2023 Aug 30.ABSTRACTGlioblastoma, the most common and aggressive type of brain tumor in adults, poses significant challenges in terms of treatment. Conventional approaches including surgery, chemotherapy, and radiotherapy have yielded limited success, with a median survival of approximately 15 months. However, extensive research into the biology of glioblastoma has identified molecular targets that can be exploited by newly developed drugs, leading to the emergence of precise personalized therapies. Several innovative treatment strategies are currently ...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: A Smolarska I Pruszynska W Wasylko K Godlewska M Markowska A Rybak J Botther P Kucharzewska J Nowakowska J Szeliga M Kubiak M Gorczak M Krol Source Type: research
Naringin modulates microglial polarization through the PPAR- γ/NF-κB signaling pathway to promote functional recovery following spinal cord injury
CONCLUSION: Nar promotes functional recovery by regulating microglial polarization and inhibiting the inflammatory response in SCI, and its mechanism may be related to the PPAR-γ/NF-κB signaling pathway activity.PMID:37661010 | DOI:10.1016/j.brainres.2023.148563
Source: Brain Research - September 3, 2023 Category: Neurology Authors: Bo Li Xi-Fan Mei Source Type: research
Targeted therapies for glioblastoma treatment
J Physiol Pharmacol. 2023 Jun;74(3). doi: 10.26402/jpp.2023.3.01. Epub 2023 Aug 30.ABSTRACTGlioblastoma, the most common and aggressive type of brain tumor in adults, poses significant challenges in terms of treatment. Conventional approaches including surgery, chemotherapy, and radiotherapy have yielded limited success, with a median survival of approximately 15 months. However, extensive research into the biology of glioblastoma has identified molecular targets that can be exploited by newly developed drugs, leading to the emergence of precise personalized therapies. Several innovative treatment strategies are currently ...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: A Smolarska I Pruszynska W Wasylko K Godlewska M Markowska A Rybak J Botther P Kucharzewska J Nowakowska J Szeliga M Kubiak M Gorczak M Krol Source Type: research
