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Cancer: Colorectal Cancer
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Total 40091 results found since Jan 2013.
Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer
CONCLUSIONS: In MSI colon cancer, LNMs are 50 % less prevalent, but the factors associated with LNM are like those in MSS colon cancer. The improved prognosis traditionally associated with early-stage MSI colon cancers dissipates with four or more LNMs. These findings should be taken into consideration by clinicians selecting the most appropriate course of treatment for MSI colon cancer.PMID:37700171 | DOI:10.1245/s10434-023-14270-0
Source: Ann Oncol - September 12, 2023 Category: Cancer & Oncology Authors: Lynn Hakki Asama Khan Mithat Gonen Zsofia Stadler Neil H Segal Jinru Shia Maria Widmar Iris H Wei J Joshua Smith Emmanouil P Pappou Garrett M Nash Philip B Paty Julio Garcia-Aguilar Martin R Weiser Source Type: research
Are 7.5gy ×2 fractions more efficient than 6gy×3 in exclusive postoperative endometrial cancer brachytherapy? a clinical and dosimetrical analysis
CONCLUSION: Considering the lack of vaginal relapses and similar LVT over time, 7.5Gy×2fractions seem more efficient in terms of patient comfort, workload, and cost. This is the first study using dosimetry parameters to compare effectivity of schedules. Larger series are needed to confirm the present results.PMID:37699447 | DOI:10.1016/j.radonc.2023.109909
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2023 Category: Radiology Authors: Faegheh Noorian Rosa Abellana Yaowen Zhang Antonio Herreros Clara Baltrons Vallentina Lancellota Luca Tagliaferri Sebastia Sabater Aureli Torne Angeles Rovirosa Source Type: research
The Influence of the Preoperative Albumin to Alkaline Phosphatase Ratio on Overall Survival in Post-Radical Surgery for Colorectal Cancer and the Construction of a Nomogram Prediction Model
CONCLUSIONS: Preoperative AAPR level was a good predictor of postoperative survival in patients undergoing laparoscopic radical CRC surgery, and AAPR <.495 was an independent risk factor for decreased postoperative OS.PMID:37698898 | DOI:10.1177/00031348231200674
Source: The American Surgeon - September 12, 2023 Category: Surgery Authors: Wenliang Jiang Feng Xun Zhenchi Li Yong Xia Haoran Hu Yujun Liu Zhibin Zhao Honggang Wang Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
Are 7.5gy ×2 fractions more efficient than 6gy×3 in exclusive postoperative endometrial cancer brachytherapy? a clinical and dosimetrical analysis
CONCLUSION: Considering the lack of vaginal relapses and similar LVT over time, 7.5Gy×2fractions seem more efficient in terms of patient comfort, workload, and cost. This is the first study using dosimetry parameters to compare effectivity of schedules. Larger series are needed to confirm the present results.PMID:37699447 | DOI:10.1016/j.radonc.2023.109909
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 12, 2023 Category: Radiology Authors: Faegheh Noorian Rosa Abellana Yaowen Zhang Antonio Herreros Clara Baltrons Vallentina Lancellota Luca Tagliaferri Sebastia Sabater Aureli Torne Angeles Rovirosa Source Type: research
Utility of psychotherapy assessed with Kessler scale in a population of cancer patients undergoing systemic oncological treatment: a mono-institutional experience
CONCLUSIONS: The use of the K10 test is helpful in monitoring the degree of psychological distress of patients facing the diagnosis of cancer and who are about to start oncological treatment. Psychotherapy is effective in reducing the distress of these patients just a few months after starting treatment.PMID:37699600 | DOI:10.21037/cco-23-54
Source: Clinical Genitourinary Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Pasquale Vitale Ida Bocchino Vincenzo De Falco Gelsomina Auletta Ilaria Di Giovanni Marco Bocchetti Annunziata Auriemma Roberto Conchiglia Raffaele Addeo Source Type: research
Predicting Trifluridine/Tipiracil Treatment Outcomes in Refractory Metastatic Colorectal Cancer Patients: A Multicenter Exploratory Analysis
CONCLUSION: With regard to the results of the previously conducted trials, the study concludes that indolent disease, good general condition, and absence of liver metastases are positive predictive factors for TTP treatment.PMID:37699377 | DOI:10.1159/000533567
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Juraj Prejac Tomislav Omr čen Jasna Radi ć Eduard Vrdoljak Ana Fr öbe Stjepko Ple ština Source Type: research
Impact of oophorectomy on survival and improving nutritional status in ovarian metastasis from colorectal adenocarcinoma
CONCLUSIONS: Oophorectomy for ovarian metastasis from colorectal cancers was safely performed. It improved the patients' symptoms and nutritional status and may result in improved prognosis.PMID:37699374 | DOI:10.1159/000533599
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Yusuke Miyagawa Masato Kitazawa Shigeo Tokumaru Satoshi Nakamura Makoto Koyama Yuta Yamamoto Satoru Miyazaki Nao Hondo Yuji Soejima Source Type: research
Survival outcome in early onset metastatic colorectal cancer: a multicenter matched-pair analysis
Conclusion Our study suggests that younger patients benefit at least to the same magnitude or even more from mCRC-treatment than patients aged 50 or above.PMID:37699362 | DOI:10.1159/000533429
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Bernhard Doleschal Dora Nieders üß-Beke Patrick Kirchweger Andreas Petzer Josef Thaler Holger Rumpold Source Type: research
SMiT: symmetric mask transformer for disease severity detection
CONCLUSION: SMiT uses a simpler strategy to achieve better results to assist physicians in making accurate clinical decisions, which can be an inspiration for making good use of the visual transformers in the field of medical imaging.PMID:37698681 | DOI:10.1007/s00432-023-05223-x
Source: Clinical Colorectal Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Chengsheng Zhang Cheng Chen Chen Chen Xiaoyi Lv Source Type: research
Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets
This study reports an analytical approach to the largest multi-parameter immunoprofiling study of clinical trial samples to date. We analysed 12,592 tissue microarray (TMA) spots from 3,545 colorectal cancers sourced from more than 240 institutions in two clinical trials (QUASAR 2 and SCOT) stained for CD4, CD8, CD20, CD68, FoxP3, pan-cytokeratin, and DAPI by mIF. TMA slides were multi-spectrally imaged and analysed by cell-based and pixel-based marker analysis. We developed an adaptive thresholding method to account for inter- and intra-slide intensity variation in TMA analysis. Applying this method effectively ameliorate...
Source: Clinical Colorectal Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Anja L Frei Anthony McGuigan Ritik Rak Sinha Mark A Glaire Faiz Jabbar Luciana Gneo Tijana Tomasevic Andrea Harkin Tim J Iveson Mark Saunders Karin Oein Noori Maka Francesco Pezella Leticia Campo Jennifer Hay Joanne Edwards Owen J Sansom Caroline Kelly Ia Source Type: research
Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC
Clin Epigenetics. 2023 Sep 11;15(1):146. doi: 10.1186/s13148-023-01562-1.ABSTRACTDysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, and alterations in histone modifications have been linked to their development and progression. Furthermore, the gut microbiota plays a crucial role in regulating immune responses and maintaining gut homeostasis, and it has been shown to exert effects on histone modifications and gene expression in host cells. Recent advances in our underst...
Source: Clinical Colorectal Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Bing Liang Yanhong Wang Jiazhen Xu Yingchun Shao Dongming Xing Source Type: research
Modulation of mitochondrial apoptosis by β2-adrenergic receptor blockage in colorectal cancer after radiotherapy: an < em > in-vivo < /em > and < em > in-vitro < /em > study
Am J Cancer Res. 2023 Aug 15;13(8):3741-3752. eCollection 2023.ABSTRACTColorectal cancer (CRC) is one of the leading causes of malignancy-related deaths worldwide. Radiotherapy is often combined with surgery to treat patients with more advanced CRC. Despite impressive initial clinical responses, radiotherapy resistance is the main reason for most treatment failures in colorectal cancer. The G protein-coupled adrenergic receptor (AR) has shown to involve in the development and radiotherapy resistance of CRC. The β2-AR blockage (ICI-118,551) can use to inhibit the progression of CRC through downregulating EGFR-Akt-ERK1/2 si...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Chung-Sheng Shi Feng-Che Kuan Chih-Chien Chin Jhy-Ming Li Source Type: research
Colorectal cancer cell-secreted exosomal miRNA N-72 promotes tumor angiogenesis by targeting CLDN18
Am J Cancer Res. 2023 Aug 15;13(8):3482-3499. eCollection 2023.ABSTRACTAngiogenesis is essential for the growth and metastasis of several malignant tumors including colorectal cancer (CRC). The molecular mechanism underlying CRC angiogenesis has not been fully elucidated. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the intercellular communication between tumor cells and neighboring endothelial cells to regulate tumor angiogenesis. In addition, exosomes have been shown to carry and deliver miRNAs to regulate angiogenesis. miRNA N-72 is a novel miRNA that plays a regulatory role in the EGF-induce...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ying Li Di Jiang Zhi-Xin Zhang Jun-Jun Zhang Hong-Yu He Jian-Li Liu Ting Wang Xia-Xia Yang Bang-Dong Liu Li-Li Yang Xiao Zhi Xiao-Bei Zhang Tian-Lun Li Yan-Rong Liu Source Type: research
