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Cancer: Colorectal Cancer
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Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
Plasma Cetuximab Concentrations Correlate With Survival in Patients With Advanced KRAS Wild Type Colorectal Cancer
CONCLUSION: The standard cetuximab dosing regimen may not be optimal for all patients. Further pharmacokinetic studies are needed to optimize cetuximab dosing given the potential improvement in OS.PMID:37704538 | DOI:10.1016/j.clcc.2023.08.006
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Di Maria Jiang Shruti Parshad Luna Zhan Hao-Wen Sim Lillian L Siu Geoffrey Liu Jeremy D Shapiro Timothy J Price Derek J Jonker Christos S Karapetis Andrew H Strickland Wenjiang Zhang Mark Jeffery Dongsheng Tu Siobhan Ng Sabe Sabesan Jenny Shannon Amanda T Source Type: research
Generalizability of Self-Supervised Training Models for Digital Pathology: A Multicountry Comparison in Colorectal Cancer
CONCLUSION: We find that using unlabeled image data for SSL pretraining in CRC related tasks is more effective than using ImageNet pretraining. Furthermore, SSL pretraining using data from multiple countries achieve more stable performance and better generalization than single-country pretraining.PMID:37703507 | DOI:10.1200/CCI.22.00178
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Zhuchen Shao Liuxi Dai Jitendra Jonnagaddala Yang Chen Yifeng Wang Zijie Fang Yongbing Zhang Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
Metabolomics analysis of amino acid and fatty acids in colorectal cancer patients based on tandem mass spectrometry
In conclusion, we assessed the difference between CRC patients and NI, which supports guidelines for an early diagnosis and effective treatment.PMID:37700848 | PMC:PMC10493213 | DOI:10.3164/jcbn.22-110
Source: Clinical Colorectal Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Zhuo Zhao Jing Bai Chang Liu Yansong Wang Shuang Wang Furong Zhao Qiufang Gu Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
Prevalence of mutations in common tumour types in Northern England and comparable utility of national and international Trial Finders
CONCLUSIONS: Regional differences in mutations may exist with advanced stage accounting for prevalence of specific mutations. A national Trial Finder shows utility in finding targeted trials whilst commercial sequencing reports may over-report 'actionable' mutations. Understanding local prevalence and trial availability could increase enrolment onto matched early phase trials.PMID:37702806 | DOI:10.1007/s00432-023-05365-y
Source: Clinical Genitourinary Cancer - September 13, 2023 Category: Cancer & Oncology Authors: S Rae E Plummer L Fitzgerald L Hogarth A Bridgewood L Brown-Schofield J Graham S Haigh C McAnulty Y Drew N Haris S Bashir R Plummer A Greystoke Source Type: research
Different oncological features of colorectal cancer codon-specific < em > KRAS < /em > mutations: Not codon 13 but codon 12 have prognostic value
CONCLUSION: This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biomarker than codon 12 mutation for CRC in a large-scale cohort.PMID:37701134 | PMC:PMC10494767 | DOI:10.3748/wjg.v29.i32.4883
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Hong-Min Ahn Duck-Woo Kim Hyeon Jeong Oh Hyung Kyung Kim Hye Seung Lee Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang Source Type: research
MicroRNAs Regulate Tumorigenesis by Downregulating SOCS3 Expression: An < em > In silico < /em > Approach
This study identifies the interactions of known (miR-203a-5p) and novel (miR-6756-5p, miR-6732-5p, miR-1203, miR-6887-5p) microRNAs with SOCS3 regions due to their maximum interactions. Identifying the interactions of these microRNAs with SOCS3 will significantly advance the understanding of oncomiRs (miRNAs that are associated with cancer development) in tumor development due to their influence on SOCS3 expression. These insights will assist in future studies to understand the significance of miRNA-SOCS3-associated tumor development and progression.PMID:37701630 | PMC:PMC10493049 | DOI:10.1177/11779322231193535
Source: Bioinformatics and Biology Insights - September 13, 2023 Category: Bioinformatics Authors: Sura Al-Asadi Hiba Mansour Ahmed Jwaid Ataimish Rusul Al-Kahachi Jamila Rampurawala Source Type: research
