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Total 412620 results found since Jan 2013.
The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7
Bioorg Chem. 2023 Sep 15;141:106864. doi: 10.1016/j.bioorg.2023.106864. Online ahead of print.ABSTRACTPhthalates such as DHEP are among the widely used compounds in industry. It has been shown that DHEP can convey various biological consequences in mammalian cells, among them, the carcinogenic effects of DHEP are emphasized. The present study aimed to assess the impact of DHEP exposure on the proliferation and invasiveness of DU145 prostate cancer cells through in vitro and in vivo models. The DU145 cells were treated with increasing concentrations of DHEP and the tumorigenic parameters were analyzed. KLF7 as a probable me...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Hecheng Li Jianping Li Yubo Ma Ziming Wang Zihe Peng Hang Xu Hang Bi Shaik Althaf Hussain Zhaolun Li Source Type: research
Toxicological profiling of a de novo synthesized benzimidazole derivative with potent and selective proapoptotic potentials against breast cancer
This study aimed to investigate the toxicological profile of 1-(6-(1H-benzo[d]imidazole-2-yl)-2-methylpyridin-3-yl) ethanone (BMPE), both in vitro and in vivo. The proapoptotic/necrotic and cell cycle arrest potentials of BMPE were assessed in MCF-7 cell line. The in vivo toxicology was assessed in female Balb/c mice by repeated dosing of 5, 25, and 50 mg/kg for 21 consecutive days, then different biochemical, inflammatory, and oxidative markers were assessed in sera/tissue homogenates of treated animals. The new derivative showed a potent selective cytotoxicity against malignant cell lines with IC50 value 0.2 μM/mL, whil...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Ebtehal K Farrag Wessam M Aziz Sylvia E Shaker Heba Shawky Dalia B Fayed Source Type: research
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
Bioorg Chem. 2023 Sep 18;141:106873. doi: 10.1016/j.bioorg.2023.106873. Online ahead of print.ABSTRACTMetastasis is the leading cause of cancer-related mortality, targeting angiogenesis emerges as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new antiangiogenic compounds with specific mechanism of action is still desired. In present study, a bioassay-guidance uncovers the EtOAc extract of a marine-derived fungus Aspergillus clavutus LZD32-24 with significant inhibitory activity against the angiogenesis in Tg (fli1a: EGFP) zebrafish model. Extensive chromatographic fractionation led to the is...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Xingchen Guo Aili Fan Xinyi Qi Dong Liu Jian Huang Wenhan Lin Source Type: research
'Thank goodness you're here'. Exploring the impact on patients, family carers and staff of enhanced 7-day specialist palliative care services: A mixed methods study
CONCLUSIONS: Enhanced seven-day services provide high quality integrated palliative care, with positive experiences for patients, carers and staff.PMID:37731382 | DOI:10.1177/02692163231201486
Source: Palliative Medicine - September 21, 2023 Category: Palliative Care Authors: Catherine Walshe C éu Mateus Sandra Varey Steven Dodd Zoe Cockshott Lu Ãs Filipe Sarah G Brearley Source Type: research
Piperlongumine induces apoptosis and autophagy via the PI3K/Akt/mTOR pathway in KB human cervical cancer cells
Food Chem Toxicol. 2023 Sep 19:114051. doi: 10.1016/j.fct.2023.114051. Online ahead of print.ABSTRACTNatural products are continuously being researched to develop safe and effective treatment options for cervical cancer, the fourth most common cancer in women. Piperlongumine (PL), an amide alkaloid mainly present in long pepper, exhibits neuroprotective and anti-cancer properties. However, the specific effect of PL in cervical cancer and the relationship between the anti-cancer pathway and autophagy remain unclear. Therefore, we aimed to investigate PL-induced apoptosis in KB human cervical cancer cells and the relationshi...
Source: Food and Chemical Toxicology - September 21, 2023 Category: Food Science Authors: Eun-Ji Han Eun-Young Choi Su-Ji Jeon Sang-Woo Lee Jun-Mo Moon Soo-Hyun Jung Bumseok Kim Sung-Dae Cho Jeong-Seok Nam Changsun Choi Jeong-Hwan Che Ji-Youn Jung Source Type: research
Benefits beyond cardiometabolic health: the potential of frequent high intensity 'exercise snacks' to improve outcomes for those living with and beyond cancer
J Physiol. 2023 Sep 21. doi: 10.1113/JP284985. Online ahead of print.ABSTRACTHigh intensity interval training (HIIT) has been shown to consistently elicit rapid and significant adaptations in a number of physiological systems, across many different healthy and clinical populations. In addition, there is increasing interest in how some acute, yet transient responses to high intensity exercise potentially reduce the risks of particular diseases. Recent work has shown that discrete, brief bouts of high intensity exercise (termed 'exercise snacks') can improve glucose control and vascular health and thus counter the negative c...
Source: The Journal of Physiology - September 21, 2023 Category: Physiology Authors: David G Jenkins James L Devin Kathryn L Weston Joseph G Jenkins Tina L Skinner Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Virus Research - September 21, 2023 Category: Virology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
Pan-cancer analysis and experimental validation identify ndc1 as a potential immunological, prognostic and therapeutic biomarker in pancreatic cancer
Aging (Albany NY). 2023 Sep 20;15. doi: 10.18632/aging.205048. Online ahead of print.ABSTRACTNDC1 is a transmembrane nucleoporin that participates in cell mitosis. In the field of oncology, NDC1 has shown its potential as a prognostic marker for multiple tumors. However, pan-cancer analysis of NDC1 to fully explore its role in tumors has not been performed and little is reported on its role in pancreatic cancers. In the present study, a pan-cancer analysis of NDC1 was performed using a bioinformatic approach. Survival analysis was performed by univariate Cox regression analysis and Kaplan-Meier survival analysis. Subsequen...
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Qian Shen Junchen Li Chuanlong Zhang Xue Pan Yi Li Xiyuan Zhang Ge'er En Bo Pang Source Type: research
Prognostic significance of < em > CTNNB1 < /em > mutation in hepatocellular carcinoma: a systematic review and meta-analysis
CONCLUSIONS: CTNNB1 mutation can serve as an indicator of favorable prognosis as well as a novel target for treatment in HCC.PMID:37733676 | DOI:10.18632/aging.205047
Source: Aging - September 21, 2023 Category: Biomedical Science Authors: Genlin Lu Jian Lin Guoqiang Song Min Chen Source Type: research
Development of a high-performance label-free electrochemical immunosensor for early cancer diagnosis using anti-CEA/Ag-MOF/GO/GCE nanocomposite
Environ Res. 2023 Sep 19:117178. doi: 10.1016/j.envres.2023.117178. Online ahead of print.ABSTRACTIn order to detect carcinoembryonic antigen (CEA) as a tumor marker in lung cancer for early cancer diagnosis, this study aimed to develop a label-free electrochemical immunosensor based on the immobilization of an Anti-CEA antibody on a metal-organic framework (MOF)-graphene oxide nanocomposite modified glassy carbon electrode (Anti-CEA/Ag-MOF/GO/GCE). Ag-MOF/GO nanocomposite was prepared on the GCE surface using the ultrasonic irradiation method, and Anti-CEA antibody was subsequently immobilized on the surface. Analysis of ...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Peng Huang Lingzhang Meng Jun Pang Haiting Huang Jing Ma Linlin He Parnian Amani Source Type: research
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
< em > PLEKHA4 < /em > is Associated with Tumour Microenvironment, Stemness, Proliferation and Poor Prognosis of Gliomas
CONCLUSIONS: PLEKHA4 is highly expressed in glioma tissues and correlated with tumour stemness, immune cell infiltration and proliferation, suggesting its potential as a novel prognostic biomarker and therapeutic target in glioma.PMID:37735118 | DOI:10.31083/j.jin2205130
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Xin Gao Yukun Liu Shunming Hong Hui Yang Bing Guan Xiaodong Ma Source Type: research
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259775. Online ahead of print.ABSTRACTMost breast cancers do not respond to immune checkpoint inhibitors and there is an urgent need to identify novel sensitization strategies. Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective macroautophagy/autophagy cargo receptors, which are both required for TBK1 activation. Specifically, disrupting the selective autophagy ...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Syn Kok Yeo Michael Haas Kanakaraju Manupati Mingang Hao Fuchun Yang Song Chen Jun-Lin Guan Source Type: research
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2258701. Online ahead of print.ABSTRACTThe VPS37A gene encodes a subunit of the endosomal sorting complex required for transport (ESCRT)-I complex that is frequently lost in a wide variety of human solid cancers. We have previously demonstrated the role of VPS37A in directing the ESCRT membrane scission machinery to seal the phagophore for autophagosome completion. Here, we report that VPS37A-deficient cells exhibit an accumulation of the apoptotic initiator CASP8 (caspase 8) on the phagophore and are primed to undergo rapid apoptosis through the intracellular death-induci...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Tatsuya Hattori Kevin A Fundora Kouta Hamamoto David M Opozda Xinwen Liang Xiaoming Liu Jiawen Zhang Yasin Uzun Yoshinori Takahashi Hong-Gang Wang Source Type: research
Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259216. Online ahead of print.ABSTRACTCrizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, which increases the risk of mortality. However, the underlying mechanism remains unclear, which causes the lack of therapeutic strategy. We established in vitro and in vivo models for crizotinib-induced cardiotoxicity and found that crizotinib caused left ventricular dysfunction, myocardial injury and p...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhifei Xu Zezheng Pan Ying Jin Zizheng Gao Feng Jiang Huangxi Fu Xueqin Chen Xiaochen Zhang Hao Yan Xiaochun Yang Bo Yang Qiaojun He Peihua Luo Source Type: research
