Filtered By:
Specialty: Molecular Biology
This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 131414 results found since Jan 2013.
A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
CONCLUSIONS: Collectively, our study highlights the utility of the dual-reporter system for real-time monitoring and quantitative analysis of protein secretion through conventional ER-Golgi and unconventional exosome pathways. Moreover, our findings unveil distinct features of exosome-mediated protein secretion, shedding light on its differential capacity, dynamics, and regulatory mechanisms compared to ER-Golgi-mediated proteins in human cells.PMID:37726652 | PMC:PMC10510171 | DOI:10.1186/s12575-023-00219-w
Source: Biological Procedures Online - September 19, 2023 Category: Molecular Biology Authors: Christopher Olson Pengyang Zhang Joy Ku Renceh Flojo Darin Boyes Biao Lu Source Type: research
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer
Conclusion: Nuclear imaging plays an important role in the diagnosis, staging, and management of thyroid cancer. The use of radioiodine imaging, thyroglobulin imaging, FDG imaging, and somatostatin receptor imaging are all valuable tools in the evaluation of thyroid cancer. With further research and development, nuclear imaging techniques have the potential to improve the diagnosis and management of thyroid cancer and other endocrine malignancies.PMID:37724677 | DOI:10.2174/1566524023666230915103723
Source: Current Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Namit Kant Singh Neemu Hage Balaji Ramamourthy Sushmitha Nagaraju Krishna Medha Kappagantu Source Type: research
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans
CONCLUSION: Our results suggested that in oral epithelial cells, the NLRP3 inflammasome might be one of the target pathways by which CSE attenuates innate immunity and leads to oral disorders.PMID:37723958 | DOI:10.2174/1566524023666230612143038
Source: Current Molecular Medicine - September 19, 2023 Category: Molecular Biology Authors: Fan Huang Ruiqi Xie Ruowei Li Liu Liu Maomao Zhao Qiong Wang Weida Liu Pei Ye Wenmei Wang Xiang Wang Source Type: research
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research
Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor
Am J Respir Cell Mol Biol. 2023 Sep 19. doi: 10.1165/rcmb.2023-0127OC. Online ahead of print.ABSTRACTGeneration of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections remain unexplored. In the present study, we investigated the role of CD36 in mediating pulmonary endothelial cell (EC) ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 19, 2023 Category: Molecular Biology Authors: Pratap Karki Yue Li Chen-Ou Zhang Yunbo Ke Kamoltip Promnares Anna A Birukova Thomas L Eggerman Alexander V Bocharov Konstantin G Birukov Source Type: research
Structural basis for inhibition of a GH116 β-glucosidase and its missense mutants by GBA2 inhibitors: Crystallographic and quantum chemical study
Chem Biol Interact. 2023 Sep 17:110717. doi: 10.1016/j.cbi.2023.110717. Online ahead of print.ABSTRACTThe crystal structure of the Thermoanaerobacterium xylanolyticum in glycoside hydrolase family 116 (TxGH116) β-glucosidase provides a structural model for human GBA2 glucosylceramidase, an enzyme defective in hereditary spastic paraplegia and a potential therapeutic target for treating Gaucher disease. To assess the therapeutic potential of known inhibitors, the X-ray structure of TxGH116 in complex with isofagomine (IFG) was determined at 2.0 Å resolution and showed the IFG bound in a relaxed chair conformation. The bin...
Source: Chemico-Biological Interactions - September 19, 2023 Category: Molecular Biology Authors: Wijitra Meelua Natechanok Thinkumrob Patchreenart Saparpakorn Salila Pengthaisong Supa Hannongbua James R Ketudat Cairns Jitrayut Jitonnom Source Type: research
Amphipathic Helical Peptide L37-pA Protects Against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor
Am J Respir Cell Mol Biol. 2023 Sep 19. doi: 10.1165/rcmb.2023-0127OC. Online ahead of print.ABSTRACTGeneration of bioactive truncated oxidized phospholipids (Tr-OxPLs) from oxidation of cell membrane or circulating lipoproteins is a common feature of various pathological states. Scavenger receptor CD36 is involved in lipid transport and acts as a ligand for Tr-OxPLs. Interestingly, both Tr-OxPLs and CD36 are involved in endothelial dysfunction-derived acute lung injury but precise mechanistic connections remain unexplored. In the present study, we investigated the role of CD36 in mediating pulmonary endothelial cell (EC) ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 19, 2023 Category: Molecular Biology Authors: Pratap Karki Yue Li Chen-Ou Zhang Yunbo Ke Kamoltip Promnares Anna A Birukova Thomas L Eggerman Alexander V Bocharov Konstantin G Birukov Source Type: research
Lactam-Fused Tropolones: A New Tunable, Environmentally Sensitive Fluorophore Class
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01263H, CommunicationDaniel Schiavone, Joel Gallardo, Diana Kapkayeva, John-Charles Baucom, Ryan Patrick Murelli Fluorescent small-molecules capable of altering their profiles in response to environmental changes are exceptionally valuable tool compounds throughout the scientific community. The following manuscriipt describes a new class of fluroescent... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 19, 2023 Category: Molecular Biology Authors: Daniel Schiavone Source Type: research
Branched Montbretin A mimics allow derivatisation and potent amylase inhibition.
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01051A, PaperMatthew Calvert, Ryan P. Sweeney, Hongming Chen, Harbir Bajwa, Seyed Amirhossein Nasseri, Davood Habibi, Stephen G. Withers Mimics of the complex flavonol glycoside Montbretin A in which a flavonol moiety is coupled to a caffeic acid via partially peptidic linkers have proved to be potent inhibitors of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 18, 2023 Category: Molecular Biology Authors: Matthew Calvert Source Type: research
Deep Learning-Based Feature Extraction from Whole-Body PET/CT Employing Maximum Intensity Projection Images: Preliminary Results of Lung Cancer Data
CONCLUSION: A 2-D image-based pre-trained model could extract image patterns of whole-body FDG PET volume by using anterior and lateral views of MIP images bypassing the direct use of 3-D PET volume that requires large datasets and resources. We suggest that this approach could be implemented as a backbone model for various applications for whole-body PET image analyses.PMID:37720886 | PMC:PMC10504178 | DOI:10.1007/s13139-023-00802-9
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Joonhyung Gil Hongyoon Choi Jin Chul Paeng Gi Jeong Cheon Keon Wook Kang Source Type: research
Correction to: Sleep and Neuroimaging
Nucl Med Mol Imaging. 2023 Oct;57(5):256. doi: 10.1007/s13139-023-00807-4. Epub 2023 May 4.ABSTRACT[This corrects the article DOI: 10.1007/s13139-020-00636-9.].PMID:37720885 | PMC:PMC10504171 | DOI:10.1007/s13139-023-00807-4
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Kyoungjune Pak Jiyoung Kim Keunyoung Kim Seong Jang Kim In Joo Kim Source Type: research
Exploring the Opportunities and Challenges of ChatGPT in Academic Writing: Reply to Bom et al
Nucl Med Mol Imaging. 2023 Oct;57(5):213-214. doi: 10.1007/s13139-023-00816-3. Epub 2023 Aug 12.NO ABSTRACTPMID:37720884 | PMC:PMC10504185 | DOI:10.1007/s13139-023-00816-3
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Arosh S Perera Molligoda Arachchige Niccol ò Stomeo Source Type: research
Bilateral Ovarian Metastases of Hepatocellular Carcinoma Diagnosed with < sup > 18 < /sup > F-Fluorocholine PET/CT in a Patient with Endometriosis
Nucl Med Mol Imaging. 2023 Oct;57(5):251-253. doi: 10.1007/s13139-023-00796-4. Epub 2023 Apr 14.ABSTRACTA 47-year-old woman with history of hepatocellular carcinoma was referred for 18F-fluorocholine PET/CT evaluation due to elevated alpha-fetoprotein. The examination showed several peritoneal uptakes and two nodular pelvic foci. Coelioscopic exploration allowed confirmation and resection of multiple peritoneal metastases from hepatocellular carcinoma while pelvic biopsies revealed endometriosis and endosalpingiosis. However, alpha-fetoprotein kept rising: subsequent 18F-fluorodesoxyglucose PET/CT exploration found no pelv...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Adrien Latg é Gerlinde Averous Anne Gressel Fran çois Faitot Benjamin Leroy-Freschini Source Type: research
Perirenal Fascia - an Uncommon Site of Metastases in Prostate Cancer Detected on < sup > 68 < /sup > Ga-PSMA-11 PET/CT
We report a case of a 50-year-old man with biopsy-proven high-risk PCa in which multiple tracer avid perirenal fascia deposits were identified on 68Ga-PSMA-11 PET/CT, in addition to multi-focal prostatic primary, extensive nodal, and skeletal metastases. This case highlights that perirenal fascia is an uncommon metastatic site in PCa.PMID:37720882 | PMC:PMC10504131 | DOI:10.1007/s13139-023-00801-w
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Kunal Ramesh Chandekar Swayamjeet Satapathy Sridhar Panaiyadiyan Rakesh Kumar Source Type: research
The Value of < sup > 18 < /sup > F-FDG PET/MRI in Detecting Lumbar Radiculopathy for Selective Percutaneous Endoscopic Discectomy: a Case Report
Nucl Med Mol Imaging. 2023 Oct;57(5):247-250. doi: 10.1007/s13139-023-00797-3. Epub 2023 Mar 29.ABSTRACTMagnetic resonance imaging (MRI) is the most popular imaging modality for investigating intervertebral disc herniation. However, it has a high chance for identifying incidental findings that are morphologically or structurally abnormal but not responsible for patients' symptoms. Although a previous study suggested that 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) may help identify neuroinflammation in lumbar radiculopathy, there is currently no direct evidence obtaine...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Chih-Ying Su Guo-Shu Huang Wei-Chou Chang Chih-Chien Wang Chun-Wen Chen Yi-Chih Hsu Source Type: research
