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Specialty: Molecular Biology
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Total 131414 results found since Jan 2013.
Modulation of paraoxonase-2 in human dermal fibroblasts by UVA-induced oxidative stress: A new potential marker of skin photodamage
Chem Biol Interact. 2023 Sep 15:110702. doi: 10.1016/j.cbi.2023.110702. Online ahead of print.ABSTRACTParaoxonase-2 (PON2) is an intracellular protein widely expressed in many cell types and tissues, whose levels are known to be modulated by oxidative stress and apoptosis induced by genetic and environmental factors. However, an environmental factor that has not been previously explored is the effect of ultraviolet A radiation (UVA), the oxidizing component of sunlight, on the modulation of PON2 in human dermal fibroblasts (HuDe). Excessive UVA radiation is known to cause direct and indirect skin damage by influencing intr...
Source: Chemico-Biological Interactions - September 17, 2023 Category: Molecular Biology Authors: Camilla Morresi Alessia Luccarini Fabio Marcheggiani Gianna Ferretti Elisabetta Damiani Tiziana Bacchetti Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Nobiletin regulates invasion, migration and metastasis in hypopharyngeal squamous cell carcinoma
This study examined the effects of NOB on the proliferation, migration, and invasiveness of the FaDu cell line derived from hypopharyngeal squamous cell carcinoma. We determined protein kinase phosphorylation by western blot analysis, migration by Transwell assay, and metastatic potential by enzyme-linked immunosorbent assay of vascular endothelial growth factor. NOB inhibited cell proliferation by 40% at concentrations of 15 µM and 40 µM, and reduced migration and induced apoptosis at 50 µM by downregulating extracellular signal-regulated kinase, protein kinase B, and phosphoinositide 3-kinase. Our results suggest that...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Marisol Rosas-Mart ínez Jos é Antonio González Rosales Gloria Guti érrez-Venegas Source Type: research
The linkage between microRNA and cancer and its delivery as cancer therapy: A mini-review
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):7-18. doi: 10.14715/cmb/2023.69.7.2.ABSTRACTThe central dogma of molecular biology was no longer "central" after ground-breaking discoveries conveyed gene expression involves more complex physiological functions in cancer pathogenesis over the last decade. MicroRNAs (miRNAs) are short non-coding RNA that regulate gene expression, affecting key molecular pathways involved in sustaining the proliferative signalling for tumour development, evasion of cellular death, invasion, angiogenesis, as well as metastasis in a plethora of cancer types. MiRNA expression is dysregulated in...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Syed Umar Faruq Syed Najmuddin Ammar Akram Kamarudin Suraya Abdul Sani Mohd Nor Faiz Norrrahim Nur 'Atikah Abdul Latif Lucky Goh Poh Wah Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
CRISPR/Cas-9 vector system: targets UL-39 and inhibits Simplexvirus humanalpha1 (HSV-1) replication in vitro
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):19-23. doi: 10.14715/cmb/2023.69.7.3.ABSTRACTSimplexvirus humanalpha1 (HSV-1) affects approximately 67% of the world's population. Here, we sought to use the CRISPR / Cas9 system with the UL39 target, essential for virus replication. The sgRNA sequence was inserted into the plasmid (PX459-UL39). Vero cells were transfected with PX459-UL39, and inhibition of viral replication was assessed 24 and 48 hours later using plaque assays and fluorescence and qPCR. Fluorescence analyses revealed the presence of anti-HSV-1 CRISPR/Cas9 within Vero cells, and qPCR showed that the vira...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: J éssica Vasques Raposo Luciana Rodrigues Carvalho Barros Lauana Ribas Torres Rafaela Barbosa da Silva Pinto Amanda De Oliveira Lopes Elen Mello de Souza Martin Hernan Bonamino Vanessa Salete de Paula Source Type: research
Integrated bioinformatics analysis of microarray data from non-small cell lung cancer
In conclusion, the identification of hsa-miR-21, hsa-miR-141, hsa-miR-200b hsa-miR-30a, hsa-miR-30d and hsa-miR-145 provides a new theoretical basis for understanding the development of NSCLC.PMID:37715441 | DOI:10.14715/cmb/2023.69.7.35
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Lulu Feng Wenping Cai Shan Jin Caipu Chun Chengyan Wang Luping Ma Hao Peng Xingxing Dong Jinfang Jiang Xianling Lu Lijuan Pang Source Type: research
Vaginal Microbiota Profile in first-trimester miscarriages cases
In this study, 435 vaginal swabs were collected from aborted women in Maternity Teaching Hospitals in Erbil and Shahid Dr. Khalid Hospital in Koya. We characterized the vaginal microbiota diversity and composition in first-trimester abortion and investigated the association between bacterial vaginosis and abortion before 12 weeks. Cultural, morphological, and biochemical characteristics for each bacterial genus were discovered, and VITEK-2 system was used to identify isolated bacteria. Samples from each type of bacteria were selected for sequencing utilizing 16 rRNA genes examining V4-V8 region for bacterial profiles. Bact...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Saman Rafeeq Abdulla Sarmad Raheem Kareem Ayad H Hasan Source Type: research
Recombinant Antibodies to Face SARS-CoV-2 Syndemic
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):24-27. doi: 10.14715/cmb/2023.69.7.4.ABSTRACTIn recent years, increasing interest has been paid to using antibody-based therapies for clinical applications. However, it is unclear whether recombinant antibodies can be combined with other scientific approaches to generate innovative solutions for mitigating severe acute respiratory syndrome coronavirus 2. In this context, the increase in this virus transmission, the number of infected people, and the interaction between social and biological processes have led to a syndemic, exacerbating the public health problem. Here, we a...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maykel Gonz ález Torres Gerardo Leyva G ómez Mar ía Luisa Del Prado-Audelo Hern án Cortés Jonathan J Maga ña Source Type: research
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1 α- and NLRP3-derived IL-1β secretion in macrophages
This study demonstrated that resveratrol significantly improved the symptoms of acute gouty arthritis and its potential mechanism may be IL-1β reduction via HIF-1α modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.PMID:37715438 | DOI:10.14715/cmb/2023.69.7.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yamen Wang Wei Li Tianhan Zhang Runmei Wang Tao Wang Qingyun Xie Meng Wei Source Type: research
Validation of secretory Immunoglobulin A (IgA) for early and efficient diagnosis of Pseudomonas aeruginosa lung infection
This study brought data-specific evidence to reveal the efficacy of secretory Immunoglobulin A (IgA) measurement in diagnosing pulmonary P. aeruginosa infection and claims its validation as a diagnostic marker. This study has included controls and patients of Pseudomonas and grouped them into four, namely, controls, chronic cases, intermittent cases, and negative group. The last group, that is, the "Negative" group, is the ones who had a history of infection but currently showed negative blood culture. The level of sIgA was quantified in all the patients and the controls and then their status of pulmonary infection was det...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yingzhen Zhou Hao Zhang Poonam Verma Dipan Samanta Manish Kumar Verma Krishan Kumar Source Type: research
Management of Acute Cerebral Infarction by Intravenous Thrombolysis with Recombinant T Cell Receptor and Plasminogen Activator and Association of Emergency Nursing Route in the Prognosis
In this study, 100 patients were randomly selected that were equally divided into experimental and control groups. The period of hospital admission, the results of the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE), the results of the Glasgow Outcome Scale (GOS), and the results of the Activities of Daily Living were all analysed before and after the intervention.. Both the amount of time it took to get a diagnosis after being admitted and the amount of time it took to receive specialised therapy after receiving a diagnosis were significantly reduced in the observation group (both P value...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Yuqi Liu None Chengyong Wang None Yuanpeng Han Source Type: research
Colonoscopy Combined with Me-Nbi to Observe the Canceration Characteristics of Colon Polyps and the Correlation of RHOC Protein Expression
In conclusion, NICE classification under colonoscopy combined with magnifying colonoscopy has a good effect on colorectal lesions. Differential diagnostic value, RhoC protein is highly expressed in colon cancer and is closely related to the occurrence of colon cancer and the depth of lesion invasion. With the progression of colorectal adenomas, the expression of RhoC protein in the lesions gradually increased.PMID:37715435 | DOI:10.14715/cmb/2023.69.7.7
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Shuqi Xu None Weimin Chen None Yiming Chen None Xuanfu Xu None Ying Dai None Jianqing Chen None Wenhui Mo None Meng Ji None Yueyue Li None Wenjing Liu Source Type: research
Functional assessment of DNA extraction methods from frozen human blood samples for Sanger sequencing analysis
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):25-33. doi: 10.14715/cmb/2023.69.8.4.ABSTRACTThe quality of input DNA is crucial for obtaining significant inferences from molecular techniques like Sanger sequencing and Next Generation Sequencing experiments. Many of the extraction methods are suitable for retrieving quality DNA from fresh blood and tissue samples, regardless of the isolation principle. However, while isolating DNA from frozen blood samples, processed tissue samples or low-quality samples, careful selection of suitable extraction methods is extremely important. Moreover, there is no standard protocol reco...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Pravi Vidyadharan Santhi Ckv Anjali Sethumadhavan Srinivas Gopala Cibin T Raghavan Madhusoodanan Urulangodi Source Type: research
Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression
In conclusion, Circ_0006251 could be identified as a biomarker for CAD which might shed light on the diagnosis and therapy of CAD.PMID:37715433 | DOI:10.14715/cmb/2023.69.8.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Weibing Zhong Lin Wang Lingbing Xiong Source Type: research
