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Total 131414 results found since Jan 2013.
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma
Mol Aspects Med. 2023 Sep 18;94:101214. doi: 10.1016/j.mam.2023.101214. Online ahead of print.ABSTRACTPseudoexfoliation is a complex, progressive, and systemic age-related disorder. The early stage of deposition of extracellular fibrillar material on ocular and extraocular tissues is termed as pseudoexfoliation syndrome (PEXS). The severe advanced stage is known as pseudoexfoliation glaucoma (PEXG), which involves increased intraocular pressure and optic nerve damage. Through genome-wide association and candidate gene studies, PEX has been associated with numerous genetic risk variants in various gene loci. However, the ge...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Ramani Shyam Kapuganti Debasmita Pankaj Alone Source Type: research
Analysis of image data from the EuroNet PHL-C2 trial indicates a potential reduction in injected F-18 FDG activities in children: a proposal to update the EANM Paediatric Dosage Card
CONCLUSION: The results of this work allow for a conservative update of the EANM Paediatric Dosage Card for [18F]FDG-PET/CT scans performed with conventional PET/CT systems.PMID:37728668 | DOI:10.1007/s00259-023-06396-w
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Johannes Tran-Gia Uta Eberlein Michael Lassmann Christine Mauz-K örholz Dieter K örholz Pietro Zuccetta Zvi Bar-Sever Ute Rosner Thomas Walter Georgi Osama Sabri Regine Kluge Arnoldo Piccardo Lars Kurch Source Type: research
< sup > 68 < /sup > GaGa ‑LNC1007 PET/CT in the evaluation of renal cell carcinoma: comparison with 2- < sup > 18 < /sup > FFDG/ < sup > 68 < /sup > GaGa-PSMA PET/CT
CONCLUSION: [68Ga]Ga-LNC1007 is a promising tracer for RCC imaging and can effectively identify aggressive pathological characteristics of RCC.PMID:37728667 | DOI:10.1007/s00259-023-06436-5
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Rong Lin Chao Wang Shaohao Chen Tingting Lin Hai Cai Shaoming Chen Yun Yang Jiaying Zhang Fuqi Xu Jingjing Zhang Xiaoyuan Chen Jie Zang Weibing Miao Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Cell Mol Life Sci. 2023 Sep 20;80(10):296. doi: 10.1007/s00018-023-04942-1.NO ABSTRACTPMID:37728633 | DOI:10.1007/s00018-023-04942-1
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Sunil Yeruva Konstanze Stangner Anna Jungwirth Matthias Hiermaier Maria Shoykhet Daniela Kugelmann Michael Hertl Shohei Egami Norito Ishii Hiroshi Koga Takashi Hashimoto Michael Weis Britt-Maria Beckmann Ruth Biller Dominik Sch üttler Stefan K ääb Jens Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Microbiome-targeted interventions for the control of oral-gut dysbiosis and chronic systemic inflammation
Trends Mol Med. 2023 Sep 18:S1471-4914(23)00191-0. doi: 10.1016/j.molmed.2023.08.006. Online ahead of print.ABSTRACTRecent research has confirmed the strong connection between imbalances in the oral and gut microbiome (oral-gut dysbiosis), periodontitis, and inflammatory conditions such as diabetes, Alzheimer's disease, and cardiovascular diseases. Microbiome modulation is crucial for preventing and treating several autoimmune and inflammatory diseases, including periodontitis. However, the causal relationships between the microbiome and its derived metabolites that mediate periodontitis and chronic inflammation constitute...
Source: Trends in Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Juan Pacheco-Yanes Eric Reynolds Jian Li Eliana Mari ño Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
The smallest infectious substructure encoding the prion strain structural determinant revealed by spontaneous dissociation of misfolded prion protein assemblies
J Mol Biol. 2023 Sep 18:168280. doi: 10.1016/j.jmb.2023.168280. Online ahead of print.ABSTRACTIt is commonly accepted that the prion replicative propensity and strain structural determinant (SSD) are encoded in the fold of PrPSc amyloid fibril assemblies. By exploring the quaternary structure dynamicity of several prion strains, we revealed that all mammalian prion assemblies exhibit the generic property of spontaneously generating two sets of discreet infectious tetrameric and dimeric species differing significantly by their specific infectivity. By using perturbation approaches such as dilution and ionic strength variati...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Jan Bohl Mohammed Moudjou Laetitia Herzog Fabienne Reine Fiona Sailler Hannah Klute Frederic Halgand Guillaume Van der Rest Yves Boulard Vincent B éringue Angelique Igel Human Rezaei Source Type: research
Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Sep 18:159395. doi: 10.1016/j.bbalip.2023.159395. Online ahead of print.ABSTRACTRecently, we reported the TRPV4 ion channel activation and its association with secondary damage after spinal cord injury (SCI). TRPV4 activation is linked with blood-spinal cord barrier (BSCB) disruption, endothelial damage, and inflammation after SCI. Specialized pro-resolving mediators (SPM) are endogenous lipid mediators released for inflammation resolution. Studies suggest that SPM could act as an endogenous antagonist of ion channels directly or indirectly at the plasma membrane. Herein, we ...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Zarna Pathak Tarang Jadav Abhishek Roy Manjeet Chopra Nidhi Singh Pinaki Sengupta Hemant Kumar Source Type: research
Exploring The "Misfolding Problem" by Systematic Discovery and Analysis of Functional-But-Degraded Proteins
Mol Biol Cell. 2023 Sep 20:mbcE23060248. doi: 10.1091/mbc.E23-06-0248. Online ahead of print.ABSTRACTIn both health and disease, the ubiquitin-proteasome system (UPS) degrades point mutants that retain partial function but have decreased stability compared to their wild-type counterparts. This class of UPS substrate includes routine translational errors and numerous human disease alleles, such as the most common cause of cystic fibrosis, ΔF508-CFTR. Yet, there is no systematic way to discover novel examples of these "minimally misfolded" substrates. To address that shortcoming, we designed a genetic screen to isolate func...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Matthew P Flagg Breanna Lam Darren K Lam Tiffany M Le Andy Kao Yousif I Slaiwa Randolph Y Hampton Source Type: research
CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells
Mol Biol Cell. 2023 Sep 20:mbcE23050152. doi: 10.1091/mbc.E23-05-0152. Online ahead of print.ABSTRACTAlthough the RAS oncogene has been extensively studied, new aspects concerning its role and regulation in normal biology and cancer continue to be discovered. Recently, others and we have shown that the mechanistic Target of Rapamycin Complex 2 (mTORC2) is a Ras effector in Dictyostelium and mammalian cells. mTORC2 plays evolutionarily conserved roles in cell survival and migration and has been linked to tumorigenesis. Since RAS is often mutated in lung cancer, we investigated whether a Ras-mTORC2 pathway contributes to enh...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Alyssa N Werner Avani I Kumar Pascale G Charest Source Type: research
The C-terminus of α-Synuclein regulates its dynamic cellular internalization by Neurexin 1β
Mol Biol Cell. 2023 Sep 20:mbcE22110496. doi: 10.1091/mbc.E22-11-0496. Online ahead of print.ABSTRACTThe aggregation of the disordered neuronal protein, α-Synuclein (αS), is the primary pathological feature of Parkinson's disease. Current hypotheses favor cell-to-cell spread of αS species as underlying disease progression, driving interest in identifying the molecular species and cellular processes involved in cellular internalization of αS. Prior work from our lab identified the chemically specific interaction between αS and the pre-synaptic adhesion protein neurexin 1β (N1β) to be capable of driving cellular inter...
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Melissa Birol Isabella Ioana Douzoglou Mu ñoz Elizabeth Rhoades Source Type: research
Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity
CONCLUSION: MAFLD and other metabolic disorders in pediatric patients with obesity are associated with an elevation of adipose tissue macrophage-related inflammation markers.PMID:37729736 | DOI:10.1016/j.cyto.2023.156372
Source: Cytokine - September 20, 2023 Category: Molecular Biology Authors: Julia Lischka Andrea Schanzer Charlotte de Gier Susanne Greber-Platzer Maximilian Zeyda Source Type: research
