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Procedure: Kidney Transplant
Therapy: Immunotherapy
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Total 175 results found since Jan 2013.
Durable complete response to early immunotherapy discontinuation in a kidney transplant recipient with advanced cutaneous squamous cell carcinoma: A case report and review of literature
CONCLUSION: Organ transplant recipients with complete response to immunotherapy for cutaneous squamous cell carcinoma may continue to respond despite early treatment cessation. This may reduce the risks of late immune-related adverse events and acute graft rejection.PMID:37734447 | DOI:10.1016/j.trim.2023.101932
Source: Transplant Immunology - September 21, 2023 Category: Transplant Surgery Authors: Ziyao Lu Mohammed Afzal Keisuke Shirai Source Type: research
Successful Shrinkage of a Giant Cutaneous Squamous Cell Carcinoma with Immunotherapy in a Kidney Transplant Recipient
Exp Clin Transplant. 2023 Jun;21(6):534-536. doi: 10.6002/ect.2023.0018.ABSTRACTA 56-year-old male living donor kidney transplant recipient presented with a giant cutaneous squamous cell carcinoma in his right parotid region. Programmed radiotherapy had been previously terminated due to lesion ulceration and bleeding. He was characterized as a terminal case. We applied cemiplimab, which is an immune checkpoint inhibitor against the pro-grammed cell death receptor PD-1. After 6 months, the cutaneous squamous cell carcinoma had shrunk and had stopped bleeding. The patient was treated with methylprednisolone, cyclosporine, an...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 17, 2023 Category: Transplant Surgery Authors: Theodoros Eleftheriadis Ioannis Samaras Antonios Spanos Athanasios Kotsakis Ioannis Stefanidis Source Type: research
Systematic Review of Calcineurin Inhibitors and Incidence of Skin Malignancies after Kidney Transplantation in Adult Patients: A Study of 309,551 Cases
In conclusion, the calcineurin inhibitors used after kidney transplantation are associated with a higher risk of skin cancer-both non-melanoma and melanoma-when compared with other immunosuppressive therapies. This finding suggests that careful monitoring for skin lesions in post-transplant patients must be conducted. However, the decision on the kind of immunotherapy used should always be considered on an individual basis for each renal transplant recipient.PMID:37366913 | DOI:10.3390/curroncol30060430
Source: Cancer Control - June 27, 2023 Category: Cancer & Oncology Authors: Aleksandra Kulbat Karolina Richter Tomasz Stefura Marta Ko łodziej-Rzepa Micha ł Kisielewski Tomasz Wojewoda Wojciech M Wysocki Source Type: research
Nephro-oncology: clinical and biochemical aspects of kidney disease and cancer
This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.PMID:37159995 | DOI:10.18388/abp.2020_6588
Source: Acta Biochim Pol - May 9, 2023 Category: Biochemistry Authors: Slawomir Lizakowski Alicja D ębska-Ślizień Ilona Kurnatowska Maciej Jan Zaucha Marcin Matuszewski Beata Naumnik Marcin Adamczak Jerzy Chudek Magdalena Durlik Carla Ferr ándiz-Pulido Bartosz Foroncewicz Ryszard Gellert Magdalena Krajewska Micha ł Nowi Source Type: research
Artificial intelligence and radiomics in evaluation of kidney lesions: a comprehensive literature review
Ther Adv Urol. 2023 Apr 17;15:17562872231164803. doi: 10.1177/17562872231164803. eCollection 2023 Jan-Dec.ABSTRACTRadiomics and artificial intelligence (AI) may increase the differentiation of benign from malignant kidney lesions, differentiation of angiomyolipoma (AML) from renal cell carcinoma (RCC), differentiation of oncocytoma from RCC, differentiation of different subtypes of RCC, to predict Fuhrman grade, to predict gene mutation through molecular biomarkers and to predict treatment response in metastatic RCC undergoing immunotherapy. Neural networks analyze imaging data. Statistical, geometrical, textural features ...
Source: Adv Data - April 28, 2023 Category: Epidemiology Authors: Matteo Ferro Felice Crocetto Biagio Barone Francesco Del Giudice Martina Maggi Giuseppe Lucarelli Gian Maria Busetto Riccardo Autorino Michele Marchioni Francesco Cantiello Fabio Crocerossa Stefano Luzzago Mattia Piccinelli Francesco Alessandro Mistretta Source Type: research
T7 peptide-decorated exosome-based nanocarrier system for delivery of Galectin-9 siRNA to stimulate macrophage repolarization in glioblastoma
ConclusionOverall, T7-Exo/siGalectin-9 promotes macrophage repolarization and restricts the immunosuppression of GBM, thus providing novel insights into and drug delivery system of immunotherapy for GBM.Graphical abstract
Source: Journal of Neuro-Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
