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Total 110862 results found since Jan 2013.
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering
Ann Biomed Eng. 2023 Sep 20. doi: 10.1007/s10439-023-03370-3. Online ahead of print.ABSTRACTTendon and ligament injuries account for a substantial proportion of disorders in the musculoskeletal system. While non-operative and operative treatment strategies have advanced, the restoration of native tendon and ligament structures after injury is still challenging due to its innate limited regenerative ability. Cell sheet technology is an innovative tool for tissue fabrication and cell transplantation in regenerative medicine. In this review, we first summarize different harvesting procedures and advantages of cell sheet techn...
Source: Annals of Biomedical Engineering - September 21, 2023 Category: Biomedical Engineering Authors: Yexin Li Ting Deng Dilihumaer Aili Yang Chen Weihong Zhu Qian Liu Source Type: research
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
The history of vaginoplasty: Technical and sociological advances
Ann Chir Plast Esthet. 2023 Sep 19:S0294-1260(23)00075-4. doi: 10.1016/j.anplas.2023.07.001. Online ahead of print.ABSTRACTTechnical advances in gender-affirming genital surgery have allowed the modern surgeon to create a vagina, vulva and clitoris from a male sex. This surgery, commonly known as vaginoplasty, should in fact be identified as aidopoiesis, since it is not a question of improving an already existing vagina but of creating a female sex. Numerous technical advances made since 1930 throughout the world now offer a safe and proven surgical strategy for female genital gender affirmation. Most of these techniques a...
Source: Annales de Chirurgie Plastique et Esthetique - September 21, 2023 Category: Cosmetic Surgery Authors: Baptiste Bertrand Anne-Sophie Perchenet Dominique Casanova Source Type: research
CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer
bioRxiv. 2023 Sep 7:2023.09.05.556397. doi: 10.1101/2023.09.05.556397. Preprint.ABSTRACTTissue resident myeloid cells (TRM) in adults have highly variable lifespans and may be derived from early embryonic yolk sac, fetal liver or bone marrow. Some of these TRM are known pathogenic participants in congenital and acquired diseases. Myeloablative conditioning and hematopoietic stem cell transplant can replace long-lived brain TRM resulting in clinical improvements in metabolic storage diseases. With the advent of antibody-drug-conjugate (ADC) targeted cell killing as a cell selective means of transplant conditioning, we asses...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Karin Gustafsson Catherine Rhee Vanessa Frodermann Elizabeth W Scadden Dan Li Yoshiko Iwamoto Rahul Palchaudhuri Sharon L Hyzy Anthony E Boitano Matthias Nahrendorf David T Scadden Source Type: research
Therapeutic benefits of nitric oxide in lung transplantation
Biomed Pharmacother. 2023 Sep 19;167:115549. doi: 10.1016/j.biopha.2023.115549. Online ahead of print.ABSTRACTLung transplantation is an evolutionary procedure from its experimental origin in the twentieth century and is now recognized as an established and routine life-saving intervention for a variety of end-stage pulmonary diseases refractory to medical management. Despite the success and continuous refinement in lung transplantation techniques, the widespread application of this important life-saving intervention is severely hampered by poor allograft quality offered from donors-after-brain-death. This has necessitated...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: George J Dugbartey Source Type: research
Personalized Medicine's Coming of Age: One Drug, One Patient
Clin Cancer Res. 2023 Sep 21. doi: 10.1158/1078-0432.CCR-23-2194. Online ahead of print.ABSTRACTA dendritic cell/myeloma fusion vaccine, given with lenalidomide and GM-CSF, did not result in a statistically significant increase in CR rates at 1-year post-transplant but was associated with a significant increase in circulating multiple myeloma-reactive lymphocytes indicative of tumor-specific immunity.PMID:37733765 | DOI:10.1158/1078-0432.CCR-23-2194
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Muzaffar H Qazilbash Larry W Kwak Source Type: research
Early T-Cell Precursor Leukemia: A High-Risk Subtype of Acute Lymphoblastic Leukemia, Single Center Experience in Jordan
CONCLUSION: ETP-ALL/LBL represents a high-risk disease subtype of adult ALL. Novel treatment strategies are needed to improve treatment outcomes in this patient's population.PMID:37730482 | DOI:10.1016/j.clml.2023.08.007
Source: Clinical Lymphoma and Myeloma - September 20, 2023 Category: Cancer & Oncology Authors: Khalid Halahleh Isra Muradi Mohammad Zakaria Khalil Lina Halahleh Maher Sughayer Nazmi Kamal Iyad Sultan Kamal Alrabi Source Type: research
Human CD34 < sup > + < /sup > -derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8 < sup > + < /sup > T cell and NK cell responses in vitro and in vivo
In this study, we aimed to dissect the phenotypic identity of these non-DCs and their potential immune modulatory functions on the potency of cDCs and pDCs in stimulating tumor-reactive CD8+ T and NK cell responses, in order to obtain rationale for clinical translation of our DC-complete vaccine. The non-DC compartment was heterogeneous and comprised of myeloid progenitors and (immature) granulocyte- and monocyte-like cells. Importantly, non-DCs potentiated toll-like receptor-induced DC maturation, as reflected by increased expression of co-stimulatory molecules and enhanced cDC-derived IL-12 and pDC-derived IFN-α product...
Source: Cellular and Molecular Life Sciences : CMLS - September 20, 2023 Category: Cytology Authors: Jesper van Eck van der Sluijs Diede van Ens Jolanda Brummelman Daan Heister Aastha Sareen Lisa Truijen Dorette S van Ingen Schenau Mirjam H M Heemskerk Marieke Griffioen Michel G D Kester Nicolaas P M Schaap Joop H Jansen Anniek B van der Waart Harry Dols Source Type: research
Disseminated Nontuberculous Mycobacterial Infection in a Tertiary Referral Hospital in South Korea: A Retrospective Observational Study
CONCLUSION: D-NTM disease is rare in a tertiary referral center in South Korea. They occur primarily in immunocompromised patients at a relatively young age. Careful investigation of the underlying immune status is required when treating patients with D-NTM disease.PMID:37727920 | DOI:10.3349/ymj.2023.0046
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Hyejin Park Young Ae Kang Youngmok Park Source Type: research
Pain management for liver transplant recipients
We present current evidence-based literature that reviews optimal pain management strategies for this challenging patient demographic.RECENT FINDINGS: Multiple studies have shown that thoracic epidurals provide superior pain control in open hepatic resections. Recent data suggests thoracic epidurals may be safely considered in select liver transplant recipients with normal preoperative coagulation status; however, this evidence is limited, and further studies are needed. When the risks of coagulopathy prohibit epidural placement, truncal blocks such as transversus abdominis plane blocks or quadratus lumborum blocks and abd...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Simrat Kaur Patrick Henthorn Adrian Hendrickse Source Type: research
Coagulation management during liver transplantation: monitoring and decision making for hemostatic interventions
Curr Opin Organ Transplant. 2023 Sep 19. doi: 10.1097/MOT.0000000000001101. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Rebalanced hemostasis describes the precarious balance of procoagulant and antithrombotic proteins in patients with severe liver failure. This review is aimed to discuss currently available coagulation monitoring tests and pertinent decision-making process for plasma coagulation factor replacements during liver transplantation (LT).RECENT FINDINGS: Contemporary viscoelastic coagulation monitoring systems have demonstrated advantages over conventional coagulation tests in assessing the patient's coagu...
Source: Current Opinion in Organ Transplantation - September 20, 2023 Category: Transplant Surgery Authors: Kofi B Vandyck Walter Rusin Samhati Mondal Kenichi A Tanaka Source Type: research
Low-MFI (median fluorescence intensity) pre-transplant DSA (donor specific antibodies) leading to anamnestic antibody mediated rejection in live-related donor kidney transplantation
We present two cases of live-related donor kidney transplants (LDKTs) with low-MFI pre-transplant DSA values who experienced an early acute antibody-mediated rejection (ABMR) as a result of an anamnestic antibody response by DSA against HLA class II antibodies. These results were confirmed by retesting of both pre-transplant and post-transplant archived sera from patients as well as freshly obtained donor cells. Our examples indicate a possible ABMR in patients with low MFI pre-transplant DSA. Reclassification of low vs. high-risk may be appropriate for some patients with low-MFI DSA."PMID:37730185 | DOI:10.1016/j.trim.2023.101931
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Rajni Chauhan Aseem Kumar Tiwari Geet Aggarwal L Gowri Suresh Mohit Kumar Shyam Bihari Bansal Source Type: research
Bioequivalence evaluation and blood concentration estimation of generic and branded tacrolimus in healthy subjects under fasting: A randomized, four-periods, two-sequences, complete repeated, crossover study
CONCLUSION: Generic tacrolimus (Ruibeirong®) is bioequivalent to branded tacrolimus (Astagraf XL®) with tolerable safety, which AUC predictive equations work well and are interchangeable between the two products.PMID:37730184 | DOI:10.1016/j.trim.2023.101933
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Yulin Niu Gongbin Lan Jina Wang Tianzhong Yan Peng Jin Source Type: research
Association between blood transfusion after kidney transplantation and risk for the development of de novo HLA donor-specific antibodies and poor clinical outcomes: A single-center retrospective study
CONCLUSIONS: Our study showed that blood transfusion after transplantation is associated with the occurrence of de novo DSAs increasing an immunological risk for poor clinical outcomes for kidney transplantation recipients.PMID:37730183 | DOI:10.1016/j.trim.2023.101930
Source: Transplant Immunology - September 20, 2023 Category: Transplant Surgery Authors: Zhong-Yu Kang Chun Liu Wei Liu Daihong Li Source Type: research
