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Vaccination: Vaccines

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Vaccine donation supports search dogs
DOGS belonging to the Search and Rescue Dog Association (SARDA) England have received a free health check and vaccinations thanks to support from the veterinary corporate group CVS. The charity's dogs are all owned by their handlers and have recently completed a deployment helping in the parts of the UK that were hit by flooding over the winter, including Cumbria and Yorkshire. During their March national training weekend at the Castleshaw Outdoor Centre in Oldham, Vicky Weedon, a vet at the CVS practice West Mount Vets, gave all the dogs a health check and vaccinated them. Ms Weedon has a long-standing relationship with t...
Source: Veterinary Record - March 23, 2016 Category: Veterinary Research Tags: News and Reports Source Type: research

Herpes zoster and the search for an effective vaccine.
This article reviews VZV pathogenesis, host responses and current vaccines available to prevent herpes zoster. This article is protected by copyright. All rights reserved. PMID: 27164323 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - May 9, 2016 Category: Allergy & Immunology Authors: Arnold N, Messaoudi I Tags: Clin Exp Immunol Source Type: research

Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets
Publication date: Available online 21 July 2017 Source:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Author(s): Mahmoud H. el Kouni Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is curren...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - July 21, 2017 Category: Molecular Biology Source Type: research

IJERPH, Vol. 15, Pages 1432: In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster
Conclusions: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations.
Source: International Journal of Environmental Research and Public Health - July 6, 2018 Category: Environmental Health Authors: Anna Bednarek Anna Bodajko-Grochowska Barbara Hasiec Robert Klepacz Katarzyna Szczekala Danuta Zarzycka Andrzej Emeryk Tags: Article Source Type: research

Secret-AAR: A web server to assess the antigenic density of proteins and homology search against bacterial and parasite secretome proteins.
Abstract The secretome refers to all the Excreted/Secreted (ES) proteins, and these are involved in critical biological processes, such as cell-cell communication, and host immune response. Recently, we introduced the abundance of antigenic regions (AAR) value to assess the protein antigenic density and to evaluate the antigenic potential of secretomes. Here, to facilitate the AAR calculation, we implemented it as a user-friendly webserver. We extended the webserver capabilities implementing a sequence-based tool for searching homologous proteins across secretomes, including experimental and predicted secretomes o...
Source: Genomics - October 11, 2018 Category: Genetics & Stem Cells Authors: Cornejo-Granados F, Hurtado-Ramírez JM, Hernández-Pando R, Ochoa-Leyva A Tags: Genomics Source Type: research

Transcriptomics of Haemophilus (Gl ässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
Haemophilus (Gl ässerella) parasuis is the etiological agent of Glässer’s disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly...
Source: BMC Veterinary Research - November 6, 2018 Category: Veterinary Research Authors: Álvaro Álvarez-Estrada, César B. Gutiérrez-Martín, Elías F. Rodríguez-Ferri and Sonia Martínez-Martínez Tags: Research article Source Type: research

Cancers, Vol. 10, Pages 492: Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
nin To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been demonstrated to be more efficient than temozolomide, or to increase efficacy of standard therapy (surgery, radiotherapy, temozolomide, steroid dexamethasone). According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18–20 months for adult patients with newly diagnosed glioblastoma. These data explain a failure of positive non-controlled phase II trials to predict positive phase III trials and should result in revision of the landmark Stupp trial as a historical control for ...
Source: Cancers - December 5, 2018 Category: Cancer & Oncology Authors: Aleksei A. Stepanenko Vladimir P. Chekhonin Tags: Review Source Type: research

Search of Hepatitis-B infection in relatives of chronic carriers in the province of Huanta, Ayacucho, Peru.
In conclusion, we found a high frequency of HBV in relatives of carriers of HBsAg. This strategy would help identify chronic carriers that can be treated and to contribute to a plan for the elimination of HBV. PMID: 30726419 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - February 7, 2019 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

Twitter cracks down on anti-vaxx content with new search tools
Users will now be directed to a 'credible public health resource' when they conduct a search using specific keywords associated with vaccines, Twitter said on Tuesday.
Source: the Mail online | Health - May 15, 2019 Category: Consumer Health News Source Type: news

Africa: The Search for an Effective HIV Vaccine Continues
[The Conversation Africa] An HIV vaccine trial that started in 2016 in South Africa was halted in February 2020. The study sponsors made the call after interim results showed that the vaccine, known as HVTN 702, did not prevent HIV. This result was disappointing, but the search for an effective HIV vaccine continues. Anatoli Kamali speaks to The Conversation Africa's Ina Skosana about other developments in the field.
Source: AllAfrica News: HIV-Aids and STDs - February 17, 2020 Category: Infectious Diseases Source Type: news

Is it right to cut corners in the search for a coronavirus cure? | Julian Savulescu
Vaccine and drug trials are slow, to account for safety. But in a pandemic time isn ’t just money – it’s lives• Coronavirus latest updates• See all our coronavirus coverageThe race is on to find a treatment for coronavirus. This race is split between two approaches: the trialling of pre-existing drugs used for similar diseases, and thehunt for a vaccine. In both instances, important ethical decisions must be made. Is it OK to reassign a treatment that comes with side-effects? And with thousands dying from coronavirus every day, is it acceptable to cut corners in the search for a vaccine?Related:Coronavirus vaccin...
Source: Guardian Unlimited Science - March 25, 2020 Category: Science Authors: Julian Savulescu Tags: Coronavirus outbreak Infectious diseases Medical research Science World news Ethics Source Type: news

Ethics and Evidence in the Search for a Vaccine and Treatments for Covid-19
In the rush to find a Covid-19 vaccine and one or more drugs to treat the deadly disease, concerns are being raised that ethical standards for conducting human clinical trials and the evidentiary standards for determining whether interventions are safe and effective, might be loosened. The post Ethics and Evidence in the Search for a Vaccine and Treatments for Covid-19 appeared first on The Hastings Center.
Source: blog.bioethics.net - April 15, 2020 Category: Medical Ethics Authors: Susan Gilbert Tags: Health Care Public Health Research Ethics clinical trials COVID-19 evidence Hastings Bioethics Forum syndicated Source Type: blogs

In the search of potential epitopes for Wuhan seafood market pneumonia virus using high order nullomers.
Abstract Alarms periodically emerge for viral pneumonia infections due to coronavirus. In all cases, these are zoonoses passing the barrier between species and infect humans. The legitimate concern of the international community is due to the fact that the new identified coronavirus, named SARS-CoV-2 (previously called 2019-nCoV), has a quite high mortality rate, around 2%, and a strong ability to spread, with an estimated reproduction number higher than 2. Even though all countries are doing their utmost to stop the pandemic, the only reliable solution to tackle the infection is the rapid development of a vaccine...
Source: Journal of Immunological Methods - April 22, 2020 Category: Allergy & Immunology Authors: Santoni D, Vergni D Tags: J Immunol Methods Source Type: research

The search for an HIV vaccine, the journey continues.
Authors: Dieffenbach CW, Fauci AS PMID: 32418357 [PubMed - in process]
Source: Journal of the International AIDS Society - May 19, 2020 Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research

The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.
Abstract Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Viral RNA was not detected in any of the serum and human milk samples tested and the infants remained asymptomatic. Our result strengthens the effectineness of stopping breastfeeding for 10 days after the inadvertent ye...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - June 4, 2020 Category: Tropical Medicine Authors: Fernandes EG, Nogueira JS, Porto VBG, Sato HK Tags: Rev Inst Med Trop Sao Paulo Source Type: research